Results 261 to 270 of about 136,789 (304)

Human leukocyte antigen (HLA)-G during pregnancy part II: Associations between maternal and fetal HLA-G genotypes and soluble HLA-G

Human Immunology, 2015
Human leukocyte antigen (HLA)-G is a class Ib molecule with restricted tissue distribution expressed on the extra-villous trophoblast and seems to have immunomodulatory functions during pregnancy. Studies have linked HLA-G polymorphisms to pregnancy complications such as preeclampsia and recurrent miscarriage.
Dahl, Mette, Klitkou, Louise, Christiansen, Ole B, Djurisic, Snezana, Piosik, Zofia Maria, Skovbo, Peter, Møller, Anna Margrethe, Steffensen, Rudi, Hviid, Thomas Vauvert F   +8 more
openaire   +4 more sources

Human Leukocyte antigen-G (HLA-G) and gastrointestinal malignancy.

Gastroenterology and hepatology from bed to bench, 2014
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Nazemalhosseini-Mojarad, Ehsan, J.K. Kuppen, Peter, Zali, Mohammad Reza   +2 more
openaire   +2 more sources

Modulation of HLA-G antigens expression in myelomonocytic cells

Human Immunology, 2000
As trophoblast cells and macrophages share cellular characteristics, we investigated the expression of HLA-G antigens during the myelomonocytic differentiation. Analyses with the 87G and 16G1 monoclonal antibodies demonstrated that HLA-G was not expressed in peripheral blood monocytes, in in vitro differentiated dendritic cells and macrophages, and in ...
M, Onno, G, Le Friec, C, Pangault, L, Amiot, V, Guilloux, B, Drénou, S, Caulet-Maugendre, P, André, R, Fauchet   +8 more
openaire   +2 more sources

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

Science, 1990
The α chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associated and secreted HLA-G antigens are prominent in first trimester villous cytotrophoblasts and are greatly reduced in third trimester cytotrophoblasts.
S, Kovats, E K, Main, C, Librach, M, Stubblebine, S J, Fisher, R, DeMars   +5 more
openaire   +2 more sources

Is antigen presentation the primary function of HLA-G?

Microbes and Infection, 2001
Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors.
P, Le Bouteiller, C, Solier
openaire   +2 more sources

Expression of the nonclassic histocompatibility antigen HLA-G by preeclamptic placenta

American Journal of Obstetrics and Gynecology, 1994
Expression of the histocompatibility antigen HLA-G may be required for appropriate invasion and remodeling of uterine spiral arteries. Inappropriate expression of this antigen may result in failure of invasion, leading to partial placental ischemia and gestational disease.To test the hypothesis that the level of expression of HLA-G is reduced in ...
G T, Colbern, M H, Chiang, E K, Main
openaire   +2 more sources

Evaluation of trophoblast HLA‐G antigen with a specific monoclonal antibody

Tissue Antigens, 1997
A monoclonal antibody to HLA‐G has been generated by immunizing HLA‐A2.1/human β2‐microglobulin (β2m) double transgenic mice with murine L cells transfected with both human β2m and HLA‐G. This monoclonal antibody, designated as G233, has been found not to cross‐react with other HLA class I antigens when tested on numerous cell lines by flow cytometry ...
Y W, Loke, A, King, T, Burrows, L, Gardner, M, Bowen, S, Hiby, S, Howlett, N, Holmes, D, Jacobs   +8 more
openaire   +2 more sources

Study of the structure and impact of human leukocyte antigen (HLA)-G-A, HLA-G-B, and HLA-G-DRB1 haplotypes in families with recurrent miscarriage

Human Immunology, 2010
A 14-base pair (bp) long insertion (ins)/deletion (del) polymorphism in exon 8 in the 3'-untranslated region of the human leukocyte antigen (HLA)-G gene is suggested to affect transcription of the gene. Carriage of the G14bp ins is associated with low levels of soluble HLA-G and increases the risk of recurrent miscarriage (RM).
Kolte, Astrid M, Steffensen, Rudi, Nielsen, Henriette S, Hviid, Thomas V, Christiansen, Ole B   +4 more
openaire   +4 more sources

Human leukocyte antigen (HLA)-G during pregnancy part I: Correlations between maternal soluble HLA-G at midterm, at term, and umbilical cord blood soluble HLA-G at term

Human Immunology, 2015
Human leukocyte antigen (HLA)-G is a class Ib molecule with restricted tissue distribution expressed on trophoblast cells and has been proposed to have immunomodulatory functions during pregnancy. Soluble HLA-G1 (sHLA-G1) can be generated by the shedding of membrane-bound HLA-G molecules; however, three soluble isoforms also exist (HLA-G5 to -G6 ...
Klitkou, Louise, Dahl, Mette, Hviid, Thomas Vauvert F, Djurisic, Snezana, Piosik, Zofia Maria, Skovbo, Peter, Møller, Anna Margrethe, Steffensen, Rudi, Christiansen, Ole B   +8 more
openaire   +3 more sources

Characterization of human leukocyte antigen-G (HLA-G) expression in endometrial adenocarcinoma

Gynecologic Oncology, 2006
The current study sought to determine if endometrial adenocarcinomas express human leukocyte antigen-G (HLA-G), an immune-regulatory protein, and if degree of expression correlates with the stage of carcinoma.Forty-four primary endometrial adenocarcinomas were tested using immunohistochemical staining with the 4H84 anti-HLA-G monoclonal antibody ...
Breton F, Barrier, Brian S, Kendall, Kathy L, Sharpe-Timms, Edward R, Kost   +3 more
openaire   +2 more sources