Results 51 to 60 of about 136,789 (304)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The role of HLA-DP mismatches and donor specific HLA-DP antibodies in kidney transplantation : a case series [PDF]

, 2021
BACKGROUND: The impact of HLA-DP mismatches on renal allograft outcome is still poorly understood and is suggested to be less than that of the other HLA loci.
Abramowicz, D, Claas, FHJ, Daniëls, L, Edmonds, MP, Hellemans, R, Kramer, CSM, Naessens, M, Senev, A, Van Laecke, Steven, Vanden Driessche, M   +9 more
core   +2 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Regulator der humanen Immunantwort: HLA-G: Humane Leukozyten-Antigene [PDF]

, 2006
In der Gebärmutter sorgen natürliche Killer-Zellen (NK-Zellen) für ein keimarmes Milieu. Nistet sich der Embryo in die Gebärmutter ein, würde auch er von NK-Zellen angegriffen werden. Zu seinem Schutz bildet er auf jeder seiner Zellen eine Oberflächenstruktur aus, das so genanntes HLA-G (Humanes Leukozyten Antigen).
Rebmann, Vera, Grosse-Wilde, Hans
openaire   +2 more sources

A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3’ UTR region, denoting expression levels, are associated with atopic dermatitis

Frontiers in Genetics, 2023
Introduction: Components of the immune response have previously been associated with the pathophysiology of atopic dermatitis (AD), specifically the Human Leukocyte Antigen (HLA) Class II region via genome-wide association studies, however the exact ...
David J. Margolis, David J. Margolis, Jamie L. Duke, Nandita Mitra, Ronald A. Berna, Ole J. Hoffstad, Jenna R. Wasserman, Amalia Dinou, Georgios Damianos, Ioanna Kotsopoulou, Nikolaos Tairis, Deborah A. Ferriola, Timothy L. Mosbruger, Tristan J. Hayeck, Tristan J. Hayeck, Albert C. Yan, Albert C. Yan, Dimitri S. Monos, Dimitri S. Monos   +18 more
doaj   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Doerner, C., Kuon, W., Pohla, Heike, Tabaczewski, P., Weiss, Elisabeth H.   +4 more
core   +1 more source

Factors influencing transfusion-associated HLA sensitization in patients bridged to heart transplantation using ventricular assist device. [PDF]

, 2020
BackgroundBridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti-HLA antibodies associated with rejection of subsequent allografts ...
Adler, Eric, Elkind, Jae, Morris, Gerald P, Ostberg-Braun, Oscar, Silva Enciso, Jorge, Sobczyk, Juliana   +5 more
core   +1 more source

Human Leukocyte Antigen-G (HLA-G) Polymorphism and Expression in Breast Cancer Patients

PLoS ONE, 2014
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer. HLA-G alleles were determined by direct DNA sequencing procedures from blood samples of 80 breast cancer patients and 80 healthy controls.
Seri Jeong, Seho Park, Byeong-Woo Park, Younhee Park, Oh-Joong Kwon, Hyon-Suk Kim   +5 more
openaire   +5 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Anticuerpos contra células del trofoblasto en el primer trimestre del embarazo Antibodies against trophoblast cells in the first quarter of pregnancy

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2011
Las células del trofoblasto no expresan los antígenos HLA clásicos de clase I (A, B, C), pero sí los antígenos HLA G que pueden generar anticuerpos capaces de tener reacción cruzada con los primeros.
María E Alfonso-Valdés, Eduardo Muñiz, Antonio Bencomo-Hernández, Rodisnel Rodríguez-Leyva, Déborah Villegas-Cruz, Rosa M Lam-Díaz, Luz M Morera-Barrios, Lisette Orbeal-Aldama, Gladys Graña-Ayllón   +8 more
doaj