Results 71 to 80 of about 106,774 (312)

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]

, 2007
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R, Friggen, Annemieke H, Geluk, Annemieke, Lin, May Young, Verduyn, Marleen JC, Voskuil, Martin I, Huygen, Kris, Franken, Kees LMC, Smith, Steven G, van Meijgaarden, Krista E, Dockrell, Hazel M, Stewart, Amanda L, Ottenhoff, Tom HM   +12 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Aberrant expression of HLA‐G antigen in interferon γ‐stimulated acute myelogenous leukaemia [PDF]

British Journal of Haematology, 2000
We have analysed the expression of HLA‐G in 40 leukaemia samples of various subtypes [seven cases of acute lymphoblastic leukaemia (ALL), 28 cases of acute myelogenous leukaemia (AML), three cases of chronic myelogenous leukaemia (CML) and two cases of chronic lymphocytic leukaemia (CLL)] by flow cytometry using HLA‐G‐specific monoclonal antibody.
Shinichi Mizuno, Nobuhiko Emi, Masanobu Kasai, Akiko Ishitani, Hidehiko Saito   +4 more
openaire   +1 more source

Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE, RODNEY E. PHILLIPS, Phillips, Rodney, Krausa, P, Phillips, R.E., Giangrande, P, SIOBHAN CROWLEY, Edwards, A., McIntyre, K., MIKE BUNCE, Morgan, B., Edwards, A, McMichael, A.J., Crowley, S, BARBARA MORGAN, ANNE EDWARDS, Morgan, B, Bunce, M, McMichael, Andrew, PETER KRAUSA, Crowley, S., Krausa, P., Goulder, P.J.R., Goulder, PJ, McIntyre, K, PAUL GIANGRANDE, ANDREW J. McMICHAEL, Giangrande, P., PHILIP J.R. GOULDER, McMichael, AJ, Bunce, M., Phillips, RE   +31 more
core   +1 more source

Vaccinia virus expressing ICP47 : a novel platform for cancer vaccines highlighting tumor epitopes and hiding viral antigens [PDF]

, 2010
Background Recombinant poxviruses expressing tumor associated antigens (TAAs) are evaluated since 20 years as immunogenic vaccine vector in clinical trials.
Raafat, Nermin Abdel Fattah
core   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Cross-Reactivity of Virus-Specific CD8+ T Cells Against Allogeneic HLA-C: Possible Implications for Pregnancy Outcome

Frontiers in Immunology, 2018
Heterologous immunity of virus-specific T cells poses a potential barrier to transplantation tolerance. Cross-reactivity to HLA-A and -B molecules has broadly been described, whereas responses to allo-HLA-C have remained ill defined.
Anita van der Zwan, Ellen M. W. van der Meer-Prins, Paula P. M. C. van Miert, Heleen van den Heuvel, Jacqueline D. H. Anholts, Dave L. Roelen, Frans H. J. Claas, Sebastiaan Heidt   +7 more
doaj   +1 more source

Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA [PDF]

, 1988
Inhaltverz.
Viitanen, A. M., Toivanen, A., Lahesmaa-Rantala, R., Weiss, Elisabeth H.   +3 more
core   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases

Journal for ImmunoTherapy of Cancer, 2016
Background Tumors avoid destruction by cytotoxic T cells (CTL) and natural killer (NK) cells by downregulation of classical human leukocyte antigens (HLA) and overexpression of non-classical HLA.
Sanne Samuels, Tanja D. de Gruijl, Debbie M. Ferns, A. Marijne Heeren, Maaike C. G. Bleeker, Gemma G. Kenter, Ekaterina S. Jordanova   +6 more
doaj   +1 more source