Results 51 to 60 of about 106,774 (312)

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Identification of Circulating Nonclassic Human Leukocyte Antigen G (HLA-G)–Like Molecules in Exudates [PDF]

Clinical Chemistry, 2011
BACKGROUNDHLA-G in biological fluids has been proposed to be useful as a tumor marker as both a diagnostic and prognostic factor. Most HLA-G measurement procedures are based on ELISA methods using highly specific antibodies. However, results of published studies are in conflict regarding the clinical utility and even the nature of HLA-G present in ...
Alvaro, Gonzalez, Estibaliz, Alegre, Ainhoa, Arroyo, Jöel, LeMaoult, José Ignacio, Echeveste   +4 more
openaire   +2 more sources

Anticuerpos contra células del trofoblasto en el primer trimestre del embarazo Antibodies against trophoblast cells in the first quarter of pregnancy

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2011
Las células del trofoblasto no expresan los antígenos HLA clásicos de clase I (A, B, C), pero sí los antígenos HLA G que pueden generar anticuerpos capaces de tener reacción cruzada con los primeros.
María E Alfonso-Valdés, Eduardo Muñiz, Antonio Bencomo-Hernández, Rodisnel Rodríguez-Leyva, Déborah Villegas-Cruz, Rosa M Lam-Díaz, Luz M Morera-Barrios, Lisette Orbeal-Aldama, Gladys Graña-Ayllón   +8 more
doaj  

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

The human leukocyte antigen G molecule (HLA-G) expression in patients with nasal polyposis

Brazilian Journal of Otorhinolaryngology, 2014
Sinonasal polyposis (NP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown.
Avelino, Melissa Ameloti Gomes, Wastowski, Isabela Jubé, Ferri, Ricardo Gimenes, Elias, Thaís Gomes Abrahão, Lima, Ana Paula Lindoso, Marinho, Larissa Cardoso, Pignatari, Shirley Shizue Nagata   +6 more
openaire   +5 more sources

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Targeting the coding sequence: opposing roles in regulating classical and non-classical MHC class I molecules by miR-16 and miR-744

Journal for ImmunoTherapy of Cancer, 2020
Background To control gene expression, microRNAs (miRNAs) are of key importance and their deregulation is associated with the development and progression of various cancer types.
Barbara Seliger, Michael Friedrich, Christoforos K Vaxevanis   +2 more
doaj   +1 more source

Identification of prostate-specific G-protein coupled receptor as a tumor antigen recognized by CD8(+) T cells for cancer immunotherapy. [PDF]

PLoS ONE, 2012
Prostate cancer is the most common cancer among elderly men in the US, and immunotherapy has been shown to be a promising strategy to treat patients with metastatic castration-resistant prostate cancer.
Satoko Matsueda, Mingjun Wang, Jinsheng Weng, Ying Li, Bingnan Yin, Jia Zou, Qingtian Li, Wei Zhao, Weiyi Peng, Xavier Legras, Christopher Loo, Rong-Fu Wang, Helen Y Wang   +12 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Human Leukocyte Antigen-G (HLA-G) Polymorphism and Expression in Breast Cancer Patients

PLoS ONE, 2014
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer. HLA-G alleles were determined by direct DNA sequencing procedures from blood samples of 80 breast cancer patients and 80 healthy controls.
Seri Jeong, Seho Park, Byeong-Woo Park, Younhee Park, Oh-Joong Kwon, Hyon-Suk Kim   +5 more
openaire   +5 more sources