Results 181 to 190 of about 676,827 (333)

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history. [PDF]

Commun Biol
ElAbd H, Mahdy AKH, Wacker EM, Gretsova M, Ellinghaus D, Dempfile A, Franke A.   +6 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes. [PDF]

PLoS Comput Biol
Mayer-Blackwell K, Minervina A, Pogorelyy M, Rawat P, Shapiro MR, Peters LD, Ford ES, Posgai AL, Vegesana K, Minot S, Koelle DM, Greiff V, Bradley P, Brusko TM, Thomas PG, Fiore-Gartland A.   +15 more
europepmc   +1 more source

Suppression of allo-human leucocyte antigen (HLA) antibodies secreted by B memory cellsin vitro: intravenous immunoglobulin (IVIg) versusa monoclonal anti-HLA-E IgG that mimics HLA-I reactivities of IVIg [PDF]

, 2014
Dong Zhu, Mepur H. Ravindranath, Paul I. Terasaki, Tôru Miyazaki, Trung H.M. Pham, Vadim Jucaud   +5 more
openalex   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

HLA-DR2, -DR5, and DRw6 associated Dw subtypes correlate with HLA-DR beta and -DQ beta restriction fragment length polymorphisms.

, 1986
M P Font, L. Gebuhrer, H Bétuel, C Freidel, J Dausset, Daniel Cohen   +5 more
openalex   +2 more sources

Racial differences in incident de novo donor-specific anti-HLA antibody among primary renal allograft recipients: results from a single center cohort study [PDF]

, 2017
Matthew J. Everly, Kimberly P. Briley, Carl E. Haisch, Georg Dieplinger, Paul Bolin, Scott A. Kendrick, Claire Morgan, Angela Q. Maldonado, Lorita M. Rebellato   +8 more
openalex   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

SARS-CoV-2 Infection Associated with HHV-6A Reactivation and an Inhibitory KIR2DL2/HLA-C1 Immunogenetic Profile. [PDF]

Microorganisms
Rizzo S, Ferraresi M, Strazzabosco G, Baroni M, Sanz JM, Passaro A, Bortolotti D, Rizzo R, Schiuma G.   +8 more
europepmc   +1 more source