Results 211 to 220 of about 676,827 (333)
Downregulation of HLA Class I Expression through HLA-A DNA Methylation Is Associated with Reduced CD8+ T-cell Infiltration in Cervical Cancer. [PDF]
Cancer Immunol ResYoshimoto D, Iuchi H, Taguchi A, Sone K, Tamai K, Mori A, Kitamura S, Duong AQ, Ishizaka A, Kusakabe M, Yamamoto Y, Takase A, Ikemura M, Matsunaga H, Iriyama T, Kukimoto I, Kawazu M, Hamada M, Ushiku T, Oda K, Takeyama H, Hirota Y, Osuga Y. +22 moreeuropepmc +1 more sourceEpstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset
Annals of Neurology, EarlyView.Objectives
Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams +37 morewiley +1 more sourceChallenges of monocyte HLA-DR targeted immunomodulation in sepsis-a prospective observational cohort study. [PDF]
Front ImmunolSnow TAC, Villa A, Cesar A, Ryckaert F, Saleem N, Smyth D, Pan H, Flint J, Brealey D, Singer M, Gilroy DW, Arulkumaran N, University College London Hospitals Critical Care Research Team. +12 moreeuropepmc +1 more sourceImmunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity
, 2022 Dhruti P. Chen, Elizabeth A. McInnis, Eveline Y. Wu, Katherine G. Stember, Susan L. Hogan, Yichun Hu, Candace D. Henderson, Lauren N. Blazek, S. Mallal, Edita Karosiene, Bjoern Peters, John Sidney, Eddie A. James, William W. Kwok, J. Charles Jennette, Dominic J. Ciavatta, Ronald J. Falk, Meghan E. Free +17 moreopenalex +2 more sourcesAssociation between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease
Annals of Neurology, EarlyView.Objective
Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross +34 morewiley +1 more sourceProgrammable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators
Angewandte Chemie, EarlyView.The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase +9 morewiley +2 more sourcesHLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors. [PDF]
Sci AdvHwang D, Erdman MC, Adhikari S, Pantula R, Epstein K, Li P, Costabile F, Rotsides P, Wang CS, Sun SM, Fazelinia H, Spruce LA, Fugmann T, Rrustemi T, Soh WT, Farrel A, Want MY, Facciabene A, Mir M, Maris JM, Sgourakis NG. +20 moreeuropepmc +1 more sourceNovel Sensitive, Specific and Rapid Pharmacogenomic test for the Prediction of Abacavir Hypersensitivity Reaction: HLA-B*57:01 Detection by Real-Time PCR
, 2011 Cinzia Dello Russo, Lucia Lisi, Alessia Lofaro, Simona Di Giambenedetto, Bruno Federico, Giordano Madeddu, Marianna Salerno, María Stella Mura, Antonella Pirazzoli, Andrea De Luca, Roberto Cauda, Pierluigi Navarra +11 moreopenalex +2 more sourcesEndogenous Repair in Vanishing White Matter
Annals of Neurology, EarlyView.Objective
Vanishing white matter is a leukodystrophy with remarkable regional variation in disease severity. The cerebral and cerebellar white matter chronically degenerates, while stress‐induced episodes of rapid neurological deterioration coincide with the appearance of acute focal lesions in the deep gray structures and brainstem.Bonnie C. Plug, Jodie H.K. Man, Marjolein Breur, Erik Nutma, Menno D. Stellingwerff, Truus E.M. Abbink, Marianna Bugiani, Marjo S. van der Knaap +7 morewiley +1 more source
