Results 31 to 40 of about 676,827 (333)

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]

, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard, Rückert, Christine, Uchanska-Ziegler, Barbara, Ziegler, Andreas   +3 more
core   +1 more source

Designing structure and E. coli strain-producer bearing SARS-CoV-2 N, S, M, E protein-related sequence antigen

Инфекция и иммунитет, 2023
T-cell immune response is extremely important in protecting human body from diverse viral infections. It is known that it can ensure viral clearance and complete recovery in patients with humoral immunodeficiency.
Vladimir V. Kopat, Anastasia A. Riabchenkova, Evgenii L. Chirak, Elizaveta R. Chirak, Anna I. Saenko, Nikolai N. Kolmakov, Andrey S. Simbirtsev, Ilya V. Dukhovlinov, Areg A. Totolian   +8 more
doaj   +1 more source

Comprehensive Analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 Loci and Squamous Cell Cervical Cancer Risk [PDF]

Cancer Research, 2008
Abstract Variation in human major histocompatibility genes may influence the risk of squamous cell cervical cancer (SCC) by altering the efficiency of the T-cell–mediated immune response to human papillomavirus (HPV) antigens. We used high-resolution methods to genotype human leukocyte antigen (HLA) class I (A, B, and Cw) and class II ...
Madeleine, Margaret M., Johnson, Lisa G., Smith, Anajane G., Hansen, John A., Nisperos, Brenda B., Li, Sue, Zhao, Lue-Ping, Daling, Janet R., Schwartz, Stephen M., Galloway, Denise A.   +9 more
openaire   +2 more sources

Association of HLA class II alleles with suicidal behavior in a Transylvanian population

Romanian Journal of Laboratory Medicine, 2023
Background: Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex is the most polymorphic gene cluster of the entire human genome, being linked to both the regulation of the immune ...
Vuscan Mihaela Elvira, Vica Mihaela Laura, Balici Stefana, Nicula Gheorghe Zsolt, Rusu Sergiu Ionica, Siserman Costel Vasile, Coman Horia George, Matei Horea Vladi   +7 more
doaj   +1 more source

HLA and cross-reactive antigen group matching for cadaver kidney allocation [PDF]

, 1997
Background. Allocation of cadaver kidneys by graded human leukocyte antigen (HLA) compatibility scoring arguably has had little effect on overall survival while prejudicing the transplant candidacy of African-American and other hard to match populations.
Allan Donner, Azuma, Beatty, Bodmer, Brenner, Callender, Chertow, D'Alessandro, David Gjertson, Duquesnoy, Gaston, Gjertson, Guttman, Held, Joan Martell, John J. Fung, John McMichael, Maldonado, Massimo Trucco, Meuwissen, Michael Eliasziw, Mickey, Mickey, Norman, Opelz, Opelz, Paul I. Terasaki, Petersdorf, Petersdorf, Port, Rapaport, Rapaport, Rodey, Rodey, Ron Shapiro, Sanfilippo, Shapiro, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takemoto, Takemoto, Terasaki, Terasaki, Thomas E. Starzl, Thompson, Van Buren, Velma Scantlebury   +54 more
core   +1 more source

Research and realization of RTI data transmission method based on attribute reflection [PDF]

MATEC Web of Conferences, 2020
In order to solve the error of simulation result because of data loss in VR-Link traditional simulation framework, in this paper data transfer mechanism of instance attribute on VR-Link object class is researched in detail.
Wang Long, Fang Juan, Xiao Qiang, Cai Liang   +3 more
doaj   +1 more source

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G., Gekeler, V., Müller, C. A., Schmidt, H., Steiert, I., Weiss, Elisabeth H.   +5 more
core   +1 more source

Tetrameric complexes of HLA-E, HLA-F, and HLA-G

Journal of Immunological Methods, 2002
HLA-E, HLA-F, and HLA-G are human nonclassical MHC class Ib molecules. To study the function and identify potential ligands of these molecules, we constructed tetrameric complexes. In this brief review, we discuss the methods used to produce such tetramers and the interesting results they provided. HLA-E tetramers bound to natural killer (NK) cells and
Allan, D, Lepin, E, Braud, V, O'Callaghan, C, Mcmichael, A   +4 more
openaire   +3 more sources

HLA diversity in the Russian population assessed by next generation sequencing

Медицинская иммунология, 2021
Next generation sequencing is used to determine full-length sequences of HLA genes at the 4-field (allelic) resolution. The study was aimed at determining frequency and diversity of HLA alleles in a cohort of blood donors from the Registry of the ...
E. G. Khamaganova, E. A. Leonov, A. R. Abdrakhimova, S. P. Khizhinskiy, T. V. Gaponova, V. G. Savchenko   +5 more
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources