In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]
Frontiers in Immunology 2014. 5:529, 2014 Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
Batalo, Michael +14 more
arxiv +11 more sources
The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. [PDF]
PLoS Pathogens, 2009 Mycobacterium tuberculosis (Mtb) resides in a long-lived phagosomal compartment that resists maturation. The manner by which Mtb antigens are processed and presented on MHC Class I molecules is poorly understood. Using human dendritic cells and IFN-gamma
Jeff E Grotzke +6 more
doaj +12 more sources
HLA Antigens in Migraine [PDF]
Headache: The Journal of Head and Face Pain, 1979 SYNOPSISFifty consecutive patients with migraine headaches were evaluated for the presence of 10 HLA‐A and 14 HLA‐B antigens by means of the microlymphocytotoxicity assay. Comparisons were made between classical and common migraine, and between patients with and without a family history of migraine.
O'Neill, Brian P. +2 more
openaire +5 more sources
HLA Antigens in Narcolepsy and Idiopathic Central Nervous System Hypersomnolence [PDF]
Sleep, 1986 Several studies have shown familial incidence of narcolepsy and idiopathic central nervous system (CNS) hypersomnia. HLA antigen studies performed in mongoloid and caucasoid narcoleptic patients on the A, B, and C loci have yielded conflicting results ...
Gaétan Poirier +4 more
openalex +2 more sources
The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies [PDF]
Journal of Immunology Research, 2016 Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic.
Edward J. Filippone, John L. Farber
doaj +5 more sources
Human T cell surface antigens bearing a structural relationship to HLA antigens. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1981 Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4.
T Cotner +4 more
openalex +2 more sources
HLA profile in patients with AIDS and tuberculosis [PDF]
Brazilian Journal of Infectious Diseases, 2008 Studies carried out in various populations have reported an association between some HLA specificities and susceptibility to tuberculosis. We investigated the class I and class II HLA profile in Brazilian patients of various ethnic backgrounds who had ...
José Fernando de Castro Figueiredo +3 more
doaj +3 more sources
Identification and biophysical characterization of Plasmodium peptide binding by common African HLAs [PDF]
Scientific ReportsHuman Leukocyte Antigens (HLA) are immunoreceptors that present peptide antigens at the cell surface to T cells as a primary mechanism of immune surveillance.
Marielle B. Frooman +6 more
doaj +2 more sources
Hla antigens in whipple's disease [PDF]
Arthritis & Rheumatism, 1987 AbstractThe prevalence of HLA–A and B antigen loci in patients with Whipple's disease was determined from data obtained in a review of the literature and from personal communications. Data on the HLA–A and B locus typing of 30 patients were available (with the exception that 1 of the patients was not typed for the HLA–B locus), and for an additional 18
William O. Dobbins, William O. Dobbins
openaire +5 more sources
Current research status of HLA in immune‐related diseases
Immunity, Inflammation and Disease, 2021 Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas.
Bingnan Liu, Yuanyuan Shao, Rong Fu
doaj +1 more source