Results 111 to 120 of about 1,234,411 (332)

Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA)–associated anticitrullinated protein antibodies (ACPAs) target various antigens by binding short citrulline amino acid motifs, resulting in heterogeneous ACPA profiles among patients. Here we analyzed ACPA patterns by recognized citrulline motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE) alleles
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Johan Askling, Caroline Grönwall   +18 more
wiley   +1 more source

Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and Their Relationship With Molecular Pathology and Disease Outcomes

Arthritis &Rheumatology, EarlyView.
Objective To assess the relationship of circulating and synovial immune cells with synovial molecular pathology and disease outcomes in patients with early rheumatoid arthritis (RA). Methods Patients with early (<12 months) treatment‐naive RA (n = 144) from the Pathobiology of Early Arthritis Cohort were included in this post hoc analysis.
Felice Rivellese, Elena Pontarini, Liliane Fossati‐Jimack, Rita A. Moura, Vasco C. Romão, João Eurico Fonseca, Alessandra Nerviani, Cankut Çubuk, Katriona Goldmann, Giovanni Giorli, Myles Lewis, Michele Bombardieri, Costantino Pitzalis, on behalf of the Pathobiology of Early Arthritis Cohort (PEAC) investigators   +13 more
wiley   +1 more source

Identification and biophysical characterization of Plasmodium peptide binding by common African HLAs

Scientific Reports
Human Leukocyte Antigens (HLA) are immunoreceptors that present peptide antigens at the cell surface to T cells as a primary mechanism of immune surveillance.
Marielle B. Frooman, Klara Choi, Maya Z. Kahn, Li-Yen Yang, Aubrielle Cunningham, Jenna M. RisCassi, Andrew C. McShan   +6 more
doaj   +1 more source

Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities

Arthritis &Rheumatology, EarlyView.
Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley   +1 more source

Amino acid sequence of an immunoglobulin-like HLA antigen heavy chain domain.

, 1979
L Trägårdh, Lars Rask, Klas G. Wiman, Jan Fohlman, P A Peterson   +4 more
openalex   +1 more source

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Clonal sharing of CD8+ T‐cells links skin and joint inflammation in psoriatic arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Psoriatic arthritis (PsA) is an HLA class I‐associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T‐cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J.A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

Letter: HLA antigens in haemochromatosis. [PDF]

BMJ, 1975
Walters, J M, Watt, D W, Stevens, F M, McCarthy, C F   +3 more
openaire   +4 more sources

A tolerogenic plasmid inhibits autoantibody production triggered by immunization with human peptidyl arginine deiminase 4.

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs).
Philippe P. Pagni, Vijetha Kumar, Nathalie C. Lambert, Eva Frison, Herve Luche, Marielle Mello, Magali Torres, Johnna D. Wesley, Matthias von Herrath, Jean Roudier, Isabelle Auger   +10 more
wiley   +1 more source

IMMUNOGENICITY OF HLA ANTIGENS PURIFIED FROM SERUM1

, 1977
Soldano Ferrone, Kamal K. Mittal, Michele Pellegrino, James P. Allison, Ralph A. Reisfeld   +4 more
openalex   +1 more source