Results 101 to 110 of about 413,113 (307)
HLA antibodies in kidney transplantation
, 2009 In renal transplantation donor-recipient HLA-matching is performed considering HLA-A, B and DR "broad" antigens. Several studies had demonstrated that sensitized patients could produce antibodies against all HLA class I and Il molecules. In 350 HLA class
Elvira Poggi +5 more
core
Antisera recognising HLA-A, -B and DRW antigens raised in rhesus monkeys.
, 2008 Rhesus monkeys were immunized with partially purified HLA-A, -B, -C and DR antigens. The resulting sera were shown to have activity against species-specific determinants on both HLA-A, -B, -C chains and beta 2 microglobulin by the use of somatic cell ...
M. J. Crumpton +4 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway +13 more
wiley +1 more source
HLA typing in Taiwanese patients with oral squamous cell carcinoma
Journal of Dental Sciences, 2014 Background/purpose: The human leukocyte antigen (HLA) system, which plays a vital role in immunity, is the most polymorphic gene complex found in the human genome. This study investigated HLA-related alleles and haplotypes in Taiwanese patients with oral
Chia-Chun Lu +4 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA). In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role ...
Aegli Athanasiadou +10 more
wiley +1 more source
Cancer InformaticsObjective: Host immunogenetics (Human Leukocyte Antigen, HLA) play a critical role in the human immune response to melanoma, influencing both melanoma prevalence and immunotherapy outcomes.
Apostolos P Georgopoulos +2 more
doaj +1 more source
Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4
Clinical and Developmental Immunology, 2010 MAGE-A antigens belong to cancer/testis (CT) antigens that are expressed in tumors but not in normal tissues except testis and placenta. MAGE-A antigens and their epitope peptides have been used in tumor immunotherapy trials.
Zheng-Cai Jia +7 more
doaj +1 more source
Studies on polymorphic alu insertions and genomic diversity within the major histocompatibility complex [PDF]
, 2005 After the initiation of the human genome sequencing project and the introduction of the field of 'bioinformatics', interest in human genetic diversity studies has been increased.
Dunn, David Suliman
core
Arthritis &Rheumatology, EarlyView.Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen +10 more
wiley +1 more source