Results 121 to 130 of about 413,113 (307)

PROSTATIC CARCINOMA AND HLA ANTIGENS [PDF]

, 1983
前立腺癌患者53例を対象としてHLA-A, BおよびDR抗原分析をおこなった.1)前立腺癌患者においてHLA-A, BおよびDRに高頻度に発現する特異抗原は認められなかった.2) HLA-A11およびHLA-B5の発現頻度が正常対照に比し前立腺癌患者において有意に低値を示した.3)前立腺癌患者stage D症例にHLA-A11を認めなかった.4)死亡症例11例にHLA-A11, HLA-B5を持つ症例は少なくHLA-A11, HLA-B5両抗原を同時に持つ者は1例のみであったA comparative ...
梅津, 敬一
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Immunogenetic profiling of HLA antigens in psoriatic arthritis: insights into clinical variability [PDF]

Introduction. Psoriatic arthritis (PsA) is a complex autoimmune disease with genetic and immunological components influencing its pathogenesis. HLA antigens are critical in determining genetic predisposition and clinical variability. This study aims to
Russu, Eugeniu
core   +1 more source

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions

Scientific Reports
Viral infections have been widely implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) pathogenesis. Recent evidence has also identified certain Human Leukocyte Antigen (HLA) alleles that are significantly associated with ME/CFS risk/
Apostolos P. Georgopoulos, Lisa M. James, Philip K. Peterson   +2 more
doaj   +1 more source

Laboratory evaluation of recipient's sensitization to HLA system antigens [PDF]

, 2016
The goal of the study was to evaluate pretransplant sensitization of kidney recipients to HLA system antigens. The objectives: 1. To identify frequency of antibodies to HLA system class I and class II antigens and to evaluate their relation to gender. 2.
Kunigonienė, Akvilė
core  

Single‐Cell RNA Sequencing of Peripheral Blood Defines Two Immunologic Subtypes of Sjögren's Disease Distinguished by Anti‐SSA Antibodies and Aberrant B Cell Populations

Arthritis &Rheumatology, EarlyView.
Objective Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Jimmie Ye, Caroline H. Shiboski   +15 more
wiley   +1 more source

HLA antigens in patients with Sjogren's syndrome

, 1988
HLA-antigens were studied in 116 Greek patients: 22 with pSS, 14 with sSS and RA, 26 with classical RA and 420 healthy controls. A statistically significant increase in HLA-DR5 was observed mainly in pSS patients with anti-Ro (SSA).
Papasteriades, C. A., Skopouli, F. N., Drosos, A. A., Moutsopoulos, H. M.   +3 more
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Early Diagnosis of Axial Spondyloarthritis Is Associated With Less Long‐Term Spinal Structural Damage: A Longitudinal Analysis of the Swiss Clinical Quality Management in Rheumatic Diseases Registry

Arthritis &Rheumatology, EarlyView.
Objective The Assessment of SpondyloArthritis international Society recently defined early axial spondyloarthritis (axSpA) as a duration of two years or less of axial symptoms. Previous studies have shown no significant difference in short‐term outcomes between patients with early and established axSpA treated with biologic/targeted synthetic disease ...
Annik Steimer, Jonas Brändli, Mauro Bachmann, Andrea Götschi, Claudia L. Rodrigues, Michael J. Nissen, Burkhard Möller, Kristina Bürki, Martin Wendiggensen, Simon Grosswiler, Michael Andor, Diana Dan, Frauke Förger, Sabine Adler, Diego Kyburz, Oliver Distler, Raphael Micheroli, Sofia Ramiro, Adrian Ciurea   +18 more
wiley   +1 more source

Islet transplantation outcomes in type 1 diabetes and transplantation of HLA-DQ8/DR4: results of a single-centre retrospective cohort in CanadaResearch in context

EClinicalMedicine
Summary: Background: In solid organ transplantation, HLA matching between donor and recipient is associated with superior outcomes. In islet transplantation, an intervention for Type 1 diabetes, HLA matching between donor and recipient is not performed ...
Shareen Forbes, Anne Halpin, Anna Lam, Don Grynoch, Richard Parker, Luis Hidalgo, David Bigam, Blaire Anderson, Khaled Dajani, Tatsuya Kin, Doug O'Gorman, Peter A. Senior, Patricia Campbell, A.M. James Shapiro   +13 more
doaj   +1 more source

Treatment‐Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Graphical Abstract Objective This study aimed to characterize whole blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or B lymphocyte stimulator/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to nonresponse. Methods Whole blood RNA sequencing was performed
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C. Jury, Coziana Ciurtin   +9 more
wiley   +1 more source