Results 81 to 90 of about 413,113 (307)

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Spatially Confined/Ligand‐Directed Ultrabright NIR‐AIE Nanoprobe for In Vitro Rapid Detection and In Situ Imaging of Bacterial Septic Arthritis

Advanced Science, EarlyView.
Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li, Jia Shu, Sijia Lv, Leilei Qin, Xuefeng Luo, PengCheng Xiao, Huan Cai, Xin Gao, Yan Zhao, Haotian Zhou, Yaji Yang, Zhenglin Zhu, Shijia Ding, Juan Li, Rui Chen, Wei Huang   +15 more
wiley   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

The role of HLA antigens in recurrent primary focal segmental glomerulosclerosis. [PDF]

Front Immunol, 2023
Batal I, Khairallah P, Weins A, Andeen NK, Stokes MB.   +4 more
europepmc   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

HLA antigens in Greek patients with cholelithiasis

, 1990
The distribution of HLA-A and B antigens was studied in 100 patients with cholelithiasis and in 202 healthy individuals all of Greek origin. An increased frequency of HLA-Aw19 was found in patients (33 per cent) compared with controls (22 per cent) (
Al-Mahmoud, I., Romania, S., Papageorgakis, N., Economidou, I., Papasteriades, C., Ollier, W., Katsas, A.   +6 more
core   +5 more sources

Identification of HLA Class I Misreads/Dropouts Using Serological Typing, in Comparison with DNA-based Typing

Iranian Journal of Allergy, Asthma and Immunology, 2016
Serology and DNA techniques are employed for Human Leukocyte Antigen (HLA) typing in different transplant centers. Results may not always correlate well and may need retyping with different technique.
Hamid Nawaz Tipu, Muhammad Mukarram Bashir, Muhammad Noman   +2 more
doaj  

Peculiarities of HLA-phenotypes in patients with pyelonephritis

Annals of Mechnikov's Institute, 2020
Introduction. Of great interest are the studies on the role of human leucocyte antigens (HLA) in pathogenesis of a disease. The kidneys is vulnerable to injury in the context of inflammatory responses, with the potential involvement of a number of ...
F Haiseniuk, V Driyanska, V Kruglikov
doaj  

A Case Report of Aggressive Fumarate Hydrase-deficient Renal Cell Carcinoma With Loss of HLA Antigens. [PDF]

Cancer Diagn Progn, 2023
Miura Y, Motoshima T, Anami T, Takemura K, Kinowaki K, Oka S, Urakami S, Kamba T, Komohara Y.   +8 more
europepmc   +1 more source