Results 31 to 40 of about 1,300,736 (395)

Enhanced expression of beta2-microglobulin and HLA antigens on human lymphoid cells by interferon.

Proceedings of the National Academy of Sciences of the United States of America, 1978
Mononuclear cells from the blood of healthy normal humans were kept in cultures under nonstimulating conditions for 16 hr in the presence or absence of human interferon.
I. Heron, M. Hokland, K. Berg
semanticscholar   +1 more source

Measles virus epitope presentation by HLA: novel insights into epitope selection, dominance and microvariation

Frontiers in Immunology, 2015
Immunity to infections with Measles Virus (MV) can involve vigorous HLA class I restricted CD8+ cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome.
Ingrid eSchellens, Ingrid eSchellens, Ingrid eSchellens, Hugo D Meiring, Ilka eHoof, Sanne eSpijkers, Sanne eSpijkers, Sanne eSpijkers, Martien C.M. Poelen, Jacqueline A.M. van Gaans-van den Brink, Ana I Costa, Ana I Costa, Harry eVennema, Can eKesmir, Debbie eVan Baarle, Debbie eVan Baarle, Debbie eVan Baarle, Cecile A.C.M. Van Els   +17 more
doaj   +1 more source

Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis.

Proceedings of the National Academy of Sciences of the United States of America, 1985
Newly synthesized class II HLA antigens being transported to the surface of human B-lymphoblastoid cell lines (B-LCL) interact with transferrin-neuraminidase conjugates internalized by means of receptor-mediated endocytosis.
P. Cresswell
semanticscholar   +1 more source

HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined

Journal of Immunology Research, 2017
Sensitization to human leukocyte antigens (HLA) in organ transplant patients causes graft rejection, according to the humoral theory of transplantation. Sensitization is almost ubiquitous as anti-HLA antibodies are found in almost all sera of transplant ...
Nadim El-Awar, Vadim Jucaud, Anh Nguyen
doaj   +1 more source

Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]

npj Systems Biology and Applications, 10(1), 105 (2024), 2023
As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv   +1 more source

Multiscreen serum analysis of highly sensitized renal dialysis patients for antibodies toward public and private class I HLA determinants: Implications for computer-predicted acceptable and unacceptable donor mismatches in kidney transplantation [PDF]

, 1990
A multiscreen serum analysis program has been developed that permits a determination of antibody specificity for the vast majority of highly sensitized patients awaiting transplantation.
Banner, BF, Duquesnoy, RJ, Fierst, JW, Iwaki, Y, Starzl, TE, Vanek, M, White, LT   +6 more
core   +1 more source

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G., Gekeler, V., Müller, C. A., Schmidt, H., Steiert, I., Weiss, Elisabeth H.   +5 more
core   +1 more source

Is There any Greater Possibility in Finding HLA-identical Unrelated Hematopoietic Stem Cell Donors among Thalassemia Families for Transplantation of Thalassemia Patients? [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2004
Background: Thalassemia is probably the most common single gene disorder causing a major public health problem in the world. Currently, allogenic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for thalassemia.
M Mohyeddin, P Alijanipour, K Alimoghaddam, A Ghavamzadeh, F Khosravi, B Nikbin   +5 more
doaj   +1 more source

EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER

Arquivos de Gastroenterologia, 2017
BACKGROUND: As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population.
Sevim GÖNEN, Sinan SARI, Yaşar KANDUR, Buket DALGIÇ, Oğuz SÖYLEMEZOĞLU   +4 more
doaj   +1 more source

Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens

Journal for ImmunoTherapy of Cancer, 2021
Background Graft-versus-host-disease (GvHD) is a major problem in allogeneic stem cell transplantation. We previously described two types of endogenous human leukocyte antigen (HLA)-II restricted antigens depending on their behavior towards HLA-DM. While
Andreas Mackensen, Hannah Reimann, Edith D van der Meijden, Judith Bausenwein, Sascha Kretschmann, Anna Luise Bernhardt, Julia Zeun, Miriam Marecek, Margarete M Karg, Tabea Haug, Lisa Meintker, Gloria Lutzny-Geier, Anita N Kremer   +12 more
doaj   +1 more source