Frontiers in Immunology, 2018 The best treatment for patients with end-stage renal disease is kidney transplantation. Although graft survival rates have improved in the last decades, patients still may lose their grafts partly due to the detrimental effects of donor-specific ...
Elena G. Kamburova +45 more
doaj +1 more source
Efficient HLA imputation from sequential SNPs data by Transformer [PDF]
arXiv, 2022 Human leukocyte antigen (HLA) genes are associated with a variety of diseases, however direct typing of HLA is time and cost consuming. Thus various imputation methods using sequential SNPs data have been proposed based on statistical or deep learning models, e.g. CNN-based model, named DEEP*HLA.
arxiv
Multiscreen serum analysis of highly sensitized renal dialysis patients for antibodies toward public and private class I HLA determinants: Implications for computer-predicted acceptable and unacceptable donor mismatches in kidney transplantation [PDF]
, 1990 A multiscreen serum analysis program has been developed that permits a determination of antibody specificity for the vast majority of highly sensitized patients awaiting transplantation.
Banner, BF +6 more
core +1 more source
OncoImmunology, 2021 Immune checkpoint inhibitors (ICIs) have improved the survival of patients with non-small cell lung cancer (NSCLC) by reinvigorating tumor-specific T cell responses.
Fiamma Berner +30 more
doaj +1 more source
HIV's evasion of the cellular immune response [PDF]
, 1999 Despite a strong cytotoxic T-lymphocyte (CTL) response directed against viral antigens, untreated individuals infected with the human immunodeficiency virus (HIV-1) develop AIDS, We have found that primary T cells infected with HIV-1 downregulate surface
Borrow P +31 more
core +2 more sources
TripHLApan: predicting HLA molecules binding peptides based on triple coding matrix and transfer learning [PDF]
arXiv, 2022 Human leukocyte antigen (HLA) is an important molecule family in the field of human immunity, which recognizes foreign threats and triggers immune responses by presenting peptides to T cells. In recent years, the synthesis of tumor vaccines to induce specific immune responses has become the forefront of cancer treatment.
arxiv
Antígenos HLA na febre reumática [PDF]
, 2000 Antígenos HLA de classe I (HLA-A e HLA-B) e II (HLA-DR) foram tipificados em um grupo de 91 pacientes com as principais formas de apresentação da febre reumática, ou seja, coréia, cardite ou artrite.
Donadi, Eduardo A. +4 more
core +2 more sources
Predicting Kidney Transplant Survival using Multiple Feature Representations for HLAs [PDF]
Proceedings of the 19th International Conference on Artificial
Intelligence in Medicine (2021) 51-60, 2021 Kidney transplantation can significantly enhance living standards for people suffering from end-stage renal disease. A significant factor that affects graft survival time (the time until the transplant fails and the patient requires another transplant) for kidney transplantation is the compatibility of the Human Leukocyte Antigens (HLAs) between the ...
arxiv
HLA predictions from long sequence read alignments, streamed directly into HLAminer [PDF]
arXiv, 2022 The rapidly changing landscape of sequencing technologies brings new opportunities to genomics research. Longer sequence reads and higher sequence throughput coupled with ever-improving base accuracy and decreasing per-base cost is now making long reads suitable for analyzing polymorphic regions of the human genome, such as those of the human leucocyte
arxiv
Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico. [PDF]
PLoS Neglected Tropical Diseases, 2018 Trypanosoma cruzi antigens TSA-1 and Tc24 have shown promise as vaccine candidates in animal studies. We evaluated here the recall immune response these antigens induce in Chagasic patients, as a first step to test their immunogenicity in humans.
Liliana E Villanueva-Lizama +11 more
doaj +1 more source