Results 61 to 70 of about 1,300,736 (395)

Derivation of a Multivariable Psoriatic Arthritis Risk Estimation Tool (PRESTO): A Step Towards Prevention

Arthritis &Rheumatology, EarlyView., 2023
Objective A simple, scalable tool that identifies psoriasis patients at high risk for developing psoriatic arthritis (PsA) could improve early diagnosis. We aimed to develop a risk prediction model for the development of PsA and to assess its performance among patients with psoriasis.
Lihi Eder, Ker‐Ai Lee, Vinod Chandran, Jessica Widdifield, Aaron M. Drucker, Christopher Ritchlin, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman   +8 more
wiley   +1 more source

Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico. [PDF]

PLoS Neglected Tropical Diseases, 2018
Trypanosoma cruzi antigens TSA-1 and Tc24 have shown promise as vaccine candidates in animal studies. We evaluated here the recall immune response these antigens induce in Chagasic patients, as a first step to test their immunogenicity in humans.
Liliana E Villanueva-Lizama, Julio V Cruz-Chan, Amarú Del C Aguilar-Cetina, Luis F Herrera-Sanchez, Jose M Rodriguez-Perez, Miguel E Rosado-Vallado, Maria J Ramirez-Sierra, Jaime Ortega-Lopez, Kathryn Jones, Peter Hotez, Maria Elena Bottazzi, Eric Dumonteil   +11 more
doaj   +1 more source

HLA antigens and asthma in Greeks

Respiratory Medicine, 1996
HLA-A and -B antigens were determined in a group of 76 Greek asthmatic patients: 35 children (1.5-15 years) and 41 adults (18-73 years). The results were compared to those of 400 healthy unrelated controls from the same population. The standard NIH lymphocytotoxicity test was applied.
Vassilis Georgoulias, J. Anagnostakis, Ph. Fessas, J. Zervas, D. Kamaroulias, J. Apostolakis, Michail Toumbis, Konstantinos Konstantopoulos   +7 more
openaire   +3 more sources

ALLOREACTIVE T LYMPHOCYTES CULTURED FROM LIVER TRANSPLANT BIOPSIES: ASSOCIATIONS OF HLA SPECIFICITY WITH CLINICOPATHOLOGICAL FINDINGS. [PDF]

, 1988
Lymphocyte cultures grown from liver allograft biopsies were shown to exhibit alloreactivity towards donor cells as measured by primed lymphocyte testing (PLT). The PLT specificity was determined in assays using HLA typed panel cells and/or by inhibition
Demetris, A Jake, Duquesnoy, Rene J, Fung, John J, Markus, Bernd H, Saidman, Susan, Starzl, Thomas E, Zeevi, Adriana   +6 more
core  

Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera

Journal of Experimental Medicine, 1988
T cell clones of donor origin that specifically react with recipient cells were obtained from a SCID patient successfully reconstituted by allogeneic fetal liver and thymus transplantation performed 10 yr ago.
M. Roncarolo, H. Yssel, J. Touraine, H. Betuel, J. D. Vries   +4 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients

Brazilian Journal of Medical and Biological Research, 1998
A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty
E.A. Donadi, J.C. Voltarelli, C.M. Paula-Santos, T. Kimachi, A.S. Ferraz   +4 more
doaj   +1 more source

TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes

BMC Bioinformatics, 2021
We previously developed TANTIGEN, a comprehensive online database cataloging more than 1000 T cell epitopes and HLA ligands from 292 tumor antigens. In TANTIGEN 2.0, we significantly expanded coverage in both immune response targets (T cell epitopes and ...
Guanglan Zhang, Lou Chitkushev, Lars Rønn Olsen, Derin B. Keskin, Vladimir Brusic   +4 more
doaj   +1 more source

Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation [PDF]

, 2018
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor ...
AbdulRazzaq, Badar, Buck, Greg, Hall, Charles E., Hashmi, Shahrukh, Jameson-Lee, Max, Kennedy, Caleb, Koparde, Vishal, Manjili, Masoud H., Meier, Jeremy, Neale, Michael, Qayyum, Rehan, Reed, Jason, Roberts, Catherine, Salman, Ali, Serrano, Myrna, Spellman, Stephen R., Toor, Amir A., Wijesinghe, Dayanjan   +17 more
core   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source