European Journal of Haematology, Volume 116, Issue 2, Page 160-168, February 2026.ABSTRACT Acute myeloid leukemia (AML) in elderly patients presents a major therapeutic challenge, as many are deemed unfit for intensive chemotherapy due to age, comorbidities, or frailty. Venetoclax in combination with hypomethylating agents (HMA) has emerged as a standard‐of‐care for this population, yet outcomes remain heterogeneous and predictive ...
Ernesto Vigna +11 more
wiley +1 more source
Sustainable Cold Mix Asphalt: A Comprehensive Review of Mechanical Innovations, Circular Economy Integration, Field Performance, and Decarbonization Pathways. [PDF]
Materials (Basel)Malik MD, Chen Y, Mu J, Dong R.
europepmc +1 more source
HMA Spec Revisions and Testing 2019
, 2019 INDOT’s HMA specifications and testing procedures went through significant changes for the 2018 construction season. As a result of lessons learned in 2018, INDOT is making some additional changes to the HMA specifications for 2019. This session presents a summary of those changes and what to expect.
openaire +1 more source
Fruit function beyond dispersal: effect of fruit decomposition on the plant microbiome assembly
New Phytologist, Volume 249, Issue 3, Page 1442-1455, February 2026.Summary The evolutionary role of fruits has primarily been linked to seed dispersal. However, their influence on the soil and plant microbiomes subsequent to their decomposition has received no attention. We hypothesized that fruit decomposition alters the soil microbiome, and consequently the plant microbiome and performance.
Daniel Hoefle +8 more
wiley +1 more source
Mitochondria of a human skeletal muscle cell line associate with the parasitophorous vacuoles of three archetypal lineages of <i>Toxoplasma gondii</i> and influence fatty acid import. [PDF]
FEMS MicrobesChristiansen C, Laue M, Blume M.
europepmc +1 more source
Molecular mechanisms of plant NLR activation and signalling
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta +3 more
wiley +1 more source
Unveiling prognosis in patients with acute myeloid leukemia treated with hypomethylating agents and venetoclax through novel risk stratification. [PDF]
Leuk Res RepSun J, Guo Z.
europepmc +1 more source
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
International Journal of Cancer, Volume 158, Issue 2, Page 342-356, 15 January 2026.Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner +3 more
wiley +1 more source
NPM1 and IDH1/2 Mutations Show Limited Prognostic Impact in Relapsed/Refractory AML: Evidence From the AVALON Cohort. [PDF]
Hematol OncolVetro C +22 more
europepmc +1 more source
Migrated Surgical Clip as a Nidus for Choledocholithiasis 8 Years Postcholecystectomy. [PDF]
ACG Case Rep JKaur A +5 more
europepmc +1 more source