Results 71 to 80 of about 54,076 (279)

Capability Development in the European Medicines Regulatory Network—A European Learning Needs Analysis and Survey Study

Clinical Pharmacology &Therapeutics, EarlyView.
The European Medicines Regulatory Network plays a critical role in safeguarding public health through the assessment and supervision of human medicines. However, rapid scientific and technological advancements have exposed capability deficits across the network, threatening timely and effective regulatory decision‐making.
Naomi Beard, Marko J. Kallio, Luca Kosec, Ulrika Espefält Westin, on behalf of the IncreaseNET consortium   +4 more
wiley   +1 more source

Correlation of Vitamin D Levels with Severity of Asthma in Children Between 6 to 12 Years

National Board of Examinations Journal of Medical Sciences
Background: Millions of children worldwide suffer from chronic asthma, a serious respiratory disease that has a major influence on everyday living and health outcomes.
Sreerekha Ajayan, Menaka palanisamy, Vidhya Sivakumaran, Viknesh Raj Raajkumar, Jeevithan Shanmugam   +4 more
doaj   +1 more source

Hierarchical Radio Resource Optimization for Heterogeneous Networks with Enhanced Inter-cell Interference Coordination (eICIC)

, 2013
Interference is a major performance bottleneck in Heterogeneous Network (HetNet) due to its multi-tier topological structure. We propose almost blank resource block (ABRB) for interference control in HetNet.
Chen, Junting, Lau, Vincent K. N., Liu, An, Ruan, Liangzhong, Xiao, Dengkun   +4 more
core   +2 more sources

Desulfovibrio‐Hydrogen Sulfide Mediates Capsaicin‐Induced Oxidative Stress and Gut Inflammation via TXNIP/NLRP3 Pathway

Food Bioengineering, EarlyView.
ABSTRACT The intake of capsaicin can disrupt the gut microecology and impact health, yet its underlying mechanism is not fully elucidated. This study, by establishing capsaicin‐induced human microbiota‐associated (HMA) mouse models revealed the molecular mechanism by which capsaicin perturbs the gut microbiota and metabolites, leading to intestinal ...
Liangliang Zhu, Xiangru Feng, Xiaoxuan Lu, Geng Han, Jiaqi Zou, Zhaoyang Dong, Ting Luo, Jiayang Jin, Mengyao Zhao, Xiaoguo Ji, Liming Zhao   +10 more
wiley   +1 more source

A Systematic, Regional Assessment of High Mountain Asia Glacier Mass Balance

Frontiers in Earth Science, 2020
High-mountain Asia (HMA) constitutes the largest glacierized region outside of the Earth's polar regions. Although available observations are limited, long-term records indicate sustained HMA glacier mass loss since ~1850, with accelerated loss in recent
David E. Shean, Shashank Bhushan, Paul Montesano, Paul Montesano, David R. Rounce, Anthony Arendt, Anthony Arendt, Batuhan Osmanoglu   +7 more
doaj   +1 more source

Antioxidant Activity and Inhibition of Carbohydrate Hydrolyzing Enzymes by Underutilized Parts From Some Plant‐Based Foods and Their Effect on Postprandial Hyperglycemia

Food Chemistry International, EarlyView.
The underutilized parts viz: pawpaw seed, banana, plantain, and potato peels showed promising antioxidant and inhibition of α‐amylase and α‐glucosidase activities (IC50 values ≤ 100 μg/mL). Similarly, pawpaw seed, banana, plantain, and potato peels reduced postprandial hyperglycemia in sucrose‐ and maltose‐induced hyperglycemia in rats.
Aminu Mohammed, Buhari Shehu Saidu, Nuhu Aliyu, Michael Peter Simon   +3 more
wiley   +1 more source

HMA/EMA medicines shortages guidance released

European Journal of Hospital Pharmacy, 2019
Earlier this month, the Heads of Medicines Agencies (HMA)/European Medicines Agency (EMA) task force on the availability of medicines for human and veterinary use released two guidance documents that seek to improve reporting and communication around medicines shortages.
openaire   +3 more sources

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, EarlyView.
What's New? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

Evaluation of hot mix asphalt(HMA) properties compacted at various temperatures [PDF]

, 2005
Hot mix asphalt (HMA) mixture compacted at various temperature has always been a concern to researcher. Compaction below the standard compaction temperature may bring reverse effect on HMA properties.
Silas Tirau, Larry
core  

Flexible and inflexible $CR$ submanifolds

, 2019
In this paper we prove new embedding results for compactly supported deformations of $CR$ submanifolds of $\mathbb{C}^{n+d}$: We show that if $M$ is a $2$-pseudoconcave $CR$ submanifold of type $(n,d)$ in $\mathbb{C}^{n+d}$, then any compactly supported $
Brinkschulte, Judith, Hill, C. Denson
core   +1 more source