Results 191 to 200 of about 51,717 (306)

Picropodophyllotoxin Mitigates Severe Inflammation Through HMGB1 Inhibition. [PDF]

Biomolecules
Han G, Kim GE, Bae JS.
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

High-mobility group box 1 protein, histone H3 and histone H4 are not associated with peripheral hypoperfusion in sepsis: a retrospective cohort study. [PDF]

Einstein (Sao Paulo)
Vesco BCD, Miranda AC, Stefani FDC, Morello LG, Zanette DL, Ferreira LEN, Menezes IAC.   +6 more
europepmc   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Protective Effects of Qingre Sanjie Jiaonang on Pulmonary Fibrosis: A Pilot Study

Journal of Inflammation Research
Liu-Cheng Li,1,* Zhi-Hui Zhang,2,* Lei Liu,3,* Bo Chen,1,* Ye-Cheng Jin,1 Yu-Zhen Wang1 1Department of Pharmacy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, People’s Republic of China; 2Shanghai ...
Li LC, Zhang ZH, Liu L, Chen B, Jin YC, Wang YZ   +5 more
doaj  

Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance. [PDF]

Int J Biol Sci
Wang JM, Zhao FY, Zhang Q, Yuan Y, Li BQ, Liu N, Li JJ, Liu C, Wang HQ.   +8 more
europepmc   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion. [PDF]

Cell Rep Med
Onimus A, Celias D, Chang S, Davis J, Mandula J, Li J, Gardner A, Hänggi K, Osunmakinde O, Soliman H, Shaw TI, Rodriguez PC, Ruffell B.   +12 more
europepmc   +1 more source

Neutrophil extracellular traps induced by activated platelets as a cause of neutrophil–platelet aggregation in β‐thalassaemia/haemoglobin E patients

British Journal of Haematology, EarlyView.
Abnormal neutrophils and platelets in splenectomised β‐thalassaemia/haemoglobin E (HbE) disease contribute to neutrophil–platelet aggregation, leading to a high risk of thrombus formation. Activated platelets induce neutrophils to generate neutrophil extracellular trap (NETs) via the P‐selectin–P‐selectin glycoprotein ligand‐1 (PSGL1) pathway, which ...
Rattanawan Thubthed, Rattanaporn Praneetponkang, Potchaman Sittipaisankul, Chayada Thiengtavor, Suwathida Chumpuchanaphai, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Duncan R. Smith, Saovaros Svasti, Pornthip Chaichompoo   +11 more
wiley   +1 more source

High Mobility Group Protein B1 Promotes Interferon Regulatory Factor 1 SUMOylation to Prime Trained Immunity of Circulating Monocytes and Aggravate the Progressive Synovial Inflammation in Knee Osteoarthritis. [PDF]

Research (Wash D C)
Jie L, Mao J, Zhang L, Fu H, Li X, Liao T, Wei Y, Liu D, Du J, Wu P, Yin S, Zhang N, Cao M, Wang P.   +13 more
europepmc   +1 more source