Results 201 to 210 of about 51,717 (306)

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

HMGB1 regulates mitochondrial structure and reactive oxygen species balance during the transition from naïve to primed pluripotency. [PDF]

Front Cell Dev Biol
Starkova TY, Ponomartsev SV, Fishman VS, Battulin NR, Aksenov ND, Bakhmet EI, Kuzmin AA, Bogolyubov DS, Sinenko SA, Tomilin AN.   +9 more
europepmc   +1 more source

Oligoprogressive renal cell carcinoma: What is the role of surgery?

BJU International, EarlyView.
Objective To provide an overview of the biological mechanism and pattern of oligoprogression in renal cell carcinoma (RCC) and the most updated role of surgery in this setting, highlighting scientific gaps and informing future implications. Methods A non‐systematic search of PubMed/MEDLINE was performed in August 2025 including guidelines, reviews, and
Chiara Re, William H.J. Ince, Leo Bickley, James P. Blackmur, Mouhamad H. Ismail, Justicia Kyeremeh, Teele Kuusk, Eva Mendes Serrao, James O. Jones, Grant D. Stewart   +9 more
wiley   +1 more source

Scoping review of preclinical and clinical studies on the role of HMGB1 in heart disease. [PDF]

NPJ Cardiovasc Health
Mao SH, Luo RG, Lee C, Ruan JL, Williams L, Guitart AV, Steiner K, Chan JKK, Berner JE, Lewis AJM, Riley PR, Nanchahal J.   +11 more
europepmc   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

CRISPLD2 protects against liver inflammation and fibrosis via GRP78 to repress HMGB1/TLR4 axis-mediated STING palmitoylation. [PDF]

Hepatol Commun
Zhang H, Wang J, Yang H, Yan Y, Zou J, Liu Z.   +5 more
europepmc   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Clinical application of HMGB1-TLR4 signaling pathway-mediated neuroinflammatory markers in infantile epileptic spasms syndrome. [PDF]

Front Immunol
Chen H, Zhong J, Chen Y, Wu H, Wang R, Yi Z, Zeng X.   +6 more
europepmc   +1 more source

Agrimoniin Alleviates Ferroptosis in Cold‐Stored DCD Liver Grafts Through Activation of the Nrf‐2 Pathway

Cell Proliferation, EarlyView.
Supplementing the liver preservation solution with agrimoniin protects donation after cardiac death (DCD) grafts by activating the Nrf‐2 pathway. This reduces ferroptosis, oxidative stress, and inflammation during cold storage, significantly improving graft viability.
Enqiang Chang, Xiaoting Liao, Guanghua Tao, Bijun Luo, Sheng He, Linghui Pan   +5 more
wiley   +1 more source

Plasma Concentrations of Endotoxin Lipopolysaccharide and High-Mobility Group Box 1 Protein Are Consistent Sex-Specific Biomarkers of Alcohol Abstinence Associated with Alcohol Use Disorder. [PDF]

Toxics
Hurtado-Guerrero I, García-Marchena N, Martín-Martín J, Flores-López M, Requena-Ocaña N, Fernández-Arjona MDM, López-Gambero AJ, Rivera P, Rubio L, Rubio G, Serrano A, Rodríguez de Fonseca F, Suarez J.   +12 more
europepmc   +1 more source