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Life Sciences, 2020
High mobility group box 1 (HMGB1) is a highly conserved nucleoprotein involving in numerous biological processes, and well known to trigger immune responses as the damage-associated molecular pattern (DAMP) in the extracellular environment. The role of HMGB1 is distinct due to its multiple functions in different subcellular location.
Zhi, Zhao +3 more
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High mobility group box 1 (HMGB1) is a highly conserved nucleoprotein involving in numerous biological processes, and well known to trigger immune responses as the damage-associated molecular pattern (DAMP) in the extracellular environment. The role of HMGB1 is distinct due to its multiple functions in different subcellular location.
Zhi, Zhao +3 more
openaire +2 more sources
Neuroscience Letters, 2015
High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In the postischemic brain, HMGB1 is massively released during acute damaging process and triggers inflammatory processes. Moreover, it has been reported HMGB1 augments the proinflammatory effect of LPS by direct interaction.
Il-Doo Kim +4 more
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High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In the postischemic brain, HMGB1 is massively released during acute damaging process and triggers inflammatory processes. Moreover, it has been reported HMGB1 augments the proinflammatory effect of LPS by direct interaction.
Il-Doo Kim +4 more
openaire +2 more sources
Production of recombinant human HMGB1 and anti-HMGB1 rabbit serum
International Immunopharmacology, 2011High-mobility group box-1 (HMGB1) plays important roles in inflammation, immune responses, and tumor progression. Since HMGB1 and its components have been shown to be mediators of a number of diseases but several sources of recombinant HMGB1 showed controversial biological activity, it is important to obtain recombinant HMGB1 with properties that ...
Qing, Lin +5 more
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HMGB1, a novel inflammatory cytokine
Clinica Chimica Acta, 2007High mobility group box 1 (HMGB1) exhibits unique biochemical functions as a biologically intrinsic requisite factor and as a toxin. As such, it is imperative to understand the mechanism by which these seemingly and diametrically opposed functions are exerted.
Shingo, Yamada, Ikuro, Maruyama
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Extracellular HMGB1 as a Proinflammatory Cytokine
Journal of Interferon & Cytokine Research, 2004High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for a long time described as a nuclear DNA-binding protein involved in nucleosome stabilization and gene transcription. Recent discoveries indicate that HMGB1 is released from activated innate immune cells or necrotic cells and functions ...
Guoqian, Chen +3 more
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HMGB1 is a bone‐active cytokine
Journal of Cellular Physiology, 2007AbstractHigh mobilitygroupbox 1 (HMGB1) is a chromatin protein that acts as an immunomodulatory cytokine upon active release from myeloid cells. HMGB1 is also an alarmin, an endogenous molecule released by dying cells that acts to initiate tissue repair.
Jieping, Yang +6 more
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HMGB1 as a DNA-binding cytokine
Journal of Leukocyte Biology, 2002AbstractHMGB1 (high mobility group box chromosomal protein 1), historically known as an abundant, nonhistone architectural chromosomal protein, is extremely conserved across species. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription.
Ulf, Andersson +3 more
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HMGB1 as a therapeutic target in disease
Journal of Cellular Physiology, 2020AbstractHigh‐mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be a prototypical damage‐associated molecular pattern (DAMP) protein, and together with its exogenous counterpart, pathogen ...
Jiaming Xue +7 more
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Discovery medicine, 2005
Extract: Survival has always been a challenge in nature and fast adaptation is the key. To adapt to new situations during evolution, cells learned to reuse available molecules for different purposes. One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) protein.
Dumitriu, IE +4 more
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Extract: Survival has always been a challenge in nature and fast adaptation is the key. To adapt to new situations during evolution, cells learned to reuse available molecules for different purposes. One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) protein.
Dumitriu, IE +4 more
openaire +2 more sources
HMGB1 and RAGE in Inflammation and Cancer
Annual Review of Immunology, 2010The immune system has evolved to respond not only to pathogens, but also to signals released from dying cells. Cell death through necrosis induces inflammation, whereas apoptotic cell death provides an important signal for tolerance induction. High mobility group box 1 (HMGB1) is a DNA-binding nuclear protein, released actively following cytokine ...
Gary P, Sims +4 more
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