Results 241 to 250 of about 51,717 (306)

Spermidine Attenuates Neuroimmune Dysfunction in Gulf War Illness via Modulation of the Gut- Brain Axis. [PDF]

Mol Neurobiol
Trivedi A, Roy S, More M, Bose D, Saha P, Kumar R, Sarkar S, Skupsky J, Tuteja A, Sullivan K, Klimas N, Chatterjee S.   +11 more
europepmc   +1 more source

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

Tumor-Bearing Status Accelerates Bleomycin-Induced Pulmonary Inflammation via Endothelial Activation. [PDF]

Thorac Cancer
Isoyama S, Yamaguchi K, Iwamoto H, Horimasu Y, Funaishi K, Shimoji K, Sakamoto S, Masuda T, Nakashima T, Ohshimo S, Hamada H, Hattori N.   +11 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Vagus nerve stimulation: anti-inflammatory effects in epilepsy. [PDF]

Front Hum Neurosci
Abzalova V, Kauynbekova S, Makhambayev G, Dmitriev A, Tuleubayev B, Koshkinbayev A, Dauletov A.   +6 more
europepmc   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Therapeutic Effects of Glycyrrhizic Acid on Dry Eye Disease: Targeting Pyroptosis, Oxidative Stress, and Epithelial Barrier Dysfunction. [PDF]

Int J Mol Sci
Chu Y, Zhang C, Chen Z, Zhang Q, Tang Y, Jiang J, Hu K.   +6 more
europepmc   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy

Biology Open
Rebecca A. Slick, Jessica Sutton, Margaret Haberman, Benjamin S. O'Brien, Jennifer A. Tinklenberg, Aashay Mardikar, Mariah J. Prom, Margaret Beatka, Melanie Gartz, Mark A. Vanden Avond, Emily Siebers, David L. Mack, J. Patrick Gonzalez, Allison D. Ebert, Kanneboyina Nagaraju, Michael W. Lawlor   +15 more
doaj   +1 more source

Role of Programmed Cell Death Pathways in Mediating Epithelial Wound Healing and Its Defects in Diabetic Corneas. [PDF]

Invest Ophthalmol Vis Sci
Gao N, Yu FX.
europepmc   +1 more source