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An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies
Pharmacology & Therapeutics, 2014HMGB1 (High-Mobility Group Box-1) is a nuclear protein that acts as an architectural chromatin-binding factor involved in the maintenance of nucleosome structure and regulation of gene transcription. It can be released into the extracellular milieu from immune and non-immune cells in response to various stimuli.
Giovanni N Roviello +2 more
exaly +5 more sources
Neuroscience Letters, 2015
High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In the postischemic brain, HMGB1 is massively released during acute damaging process and triggers inflammatory processes. Moreover, it has been reported HMGB1 augments the proinflammatory effect of LPS by direct interaction.
Il-Doo Kim +4 more
openaire +2 more sources
High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In the postischemic brain, HMGB1 is massively released during acute damaging process and triggers inflammatory processes. Moreover, it has been reported HMGB1 augments the proinflammatory effect of LPS by direct interaction.
Il-Doo Kim +4 more
openaire +2 more sources
Life Sciences, 2020
High mobility group box 1 (HMGB1) is a highly conserved nucleoprotein involving in numerous biological processes, and well known to trigger immune responses as the damage-associated molecular pattern (DAMP) in the extracellular environment. The role of HMGB1 is distinct due to its multiple functions in different subcellular location.
Zhi, Zhao +3 more
openaire +2 more sources
High mobility group box 1 (HMGB1) is a highly conserved nucleoprotein involving in numerous biological processes, and well known to trigger immune responses as the damage-associated molecular pattern (DAMP) in the extracellular environment. The role of HMGB1 is distinct due to its multiple functions in different subcellular location.
Zhi, Zhao +3 more
openaire +2 more sources
Production of recombinant human HMGB1 and anti-HMGB1 rabbit serum
International Immunopharmacology, 2011High-mobility group box-1 (HMGB1) plays important roles in inflammation, immune responses, and tumor progression. Since HMGB1 and its components have been shown to be mediators of a number of diseases but several sources of recombinant HMGB1 showed controversial biological activity, it is important to obtain recombinant HMGB1 with properties that ...
Qing, Lin +5 more
openaire +2 more sources
HMGB1 as a therapeutic target in disease
Journal of Cellular Physiology, 2020AbstractHigh‐mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be a prototypical damage‐associated molecular pattern (DAMP) protein, and together with its exogenous counterpart, pathogen ...
Jiaming Xue +7 more
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HMGB1, a novel inflammatory cytokine
Clinica Chimica Acta, 2007High mobility group box 1 (HMGB1) exhibits unique biochemical functions as a biologically intrinsic requisite factor and as a toxin. As such, it is imperative to understand the mechanism by which these seemingly and diametrically opposed functions are exerted.
Shingo, Yamada, Ikuro, Maruyama
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The release and activity of HMGB1 in ferroptosis
Biochemical and Biophysical Research Communications, 2019Damage-associated molecular pattern molecules (DAMPs) are endogenous danger signals that alert the innate immune system and shape the inflammation response to cell death. However, the release and activity of DAMPs in ferroptosis, a recently identified form of regulated necrosis characterized by iron overload and lipid peroxidation, still remain poorly ...
Daolin Tang, Rui Kang, Jiao Liu
exaly +3 more sources
Discovery medicine, 2005
Extract: Survival has always been a challenge in nature and fast adaptation is the key. To adapt to new situations during evolution, cells learned to reuse available molecules for different purposes. One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) protein.
Dumitriu, IE +4 more
openaire +2 more sources
Extract: Survival has always been a challenge in nature and fast adaptation is the key. To adapt to new situations during evolution, cells learned to reuse available molecules for different purposes. One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) protein.
Dumitriu, IE +4 more
openaire +2 more sources
Molecular characterization of the canine HMGB1
Cytogenetic and Genome Research, 2003Due to the close similarities of numerous canine diseases to their human counterparts, the dog could join the mouse as the species of choice to unravel the genetic background of complex diseases as e.g. cancer and metabolic diseases. Accordingly, the role of the dog as a model for therapeutic approaches is strongly increasing. However, prerequisite for
H, Murua Escobar +6 more
openaire +2 more sources
Extracellular HMGB1 as a Proinflammatory Cytokine
Journal of Interferon & Cytokine Research, 2004High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for a long time described as a nuclear DNA-binding protein involved in nucleosome stabilization and gene transcription. Recent discoveries indicate that HMGB1 is released from activated innate immune cells or necrotic cells and functions ...
Guoqian, Chen +3 more
openaire +2 more sources