Results 271 to 280 of about 71,842 (286)
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HMGB1, a novel inflammatory cytokine
Clinica Chimica Acta, 2007High mobility group box 1 (HMGB1) exhibits unique biochemical functions as a biologically intrinsic requisite factor and as a toxin. As such, it is imperative to understand the mechanism by which these seemingly and diametrically opposed functions are exerted.
Shingo, Yamada, Ikuro, Maruyama
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HMGB1: guiding immunity from within
Trends in Immunology, 2005Two of the main challenges that eukaryotic multicellular organisms faced during evolution were to eliminate and replace dying cells and to cope with invading microorganisms. The innate immune system evolved to handle both tasks: to scavenge cellular debris and to form the first line of defence against microbes. In this review, we focus on high mobility
Dumitriu IE +4 more
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Discovery medicine, 2005
Extract: Survival has always been a challenge in nature and fast adaptation is the key. To adapt to new situations during evolution, cells learned to reuse available molecules for different purposes. One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) protein.
Dumitriu, IE +4 more
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Extract: Survival has always been a challenge in nature and fast adaptation is the key. To adapt to new situations during evolution, cells learned to reuse available molecules for different purposes. One example of a molecule recruited from an extant cellular pathway into new functions is the high mobility group box 1 (HMGB1) protein.
Dumitriu, IE +4 more
openaire +2 more sources
An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies
Pharmacology & Therapeutics, 2014HMGB1 (High-Mobility Group Box-1) is a nuclear protein that acts as an architectural chromatin-binding factor involved in the maintenance of nucleosome structure and regulation of gene transcription. It can be released into the extracellular milieu from immune and non-immune cells in response to various stimuli.
MUSUMECI, DOMENICA +2 more
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Increased HMGB1 serum levels and altered HMGB1 expression in patients with psoriasis vulgaris
Archives of Dermatological Research, 2013High mobility group box-1 (HMGB1) has been implicated as a pro-inflammatory cytokine in the pathogenesis of various inflammatory and autoimmune diseases. However, information about HMGB1 in inflammatory skin diseases is unknown. Herein, we investigated the serum HMGB1 levels and tissue HMGB1 expression in patients with psoriasis vulgaris (PV) and ...
Tao, Chen +7 more
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The HMGB1 acidic tail regulates HMGB1 DNA binding specificity by a unique mechanism
Biochemical and Biophysical Research Communications, 2007HMGB1 is a conserved chromosomal protein composed of two DNA-binding domains and an acidic C-terminal tail. There were evidences suggesting that the C-terminal tail contributed to the DNA binding specificity of the N-terminal DNA-binding domains. However, the mechanism underlining this observation is largely unknown.
Qiyu, Wang +3 more
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Expression of HMGB1 during tooth development
Cell and Tissue Research, 2006High mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that can act as a transcription factor, a growth factor, or a cytokine. To elucidate a possible role for HMGB1 in tooth development, we have studied the expression of HMGB1 and its receptor RAGE (receptor for advanced glycation end-products) during the late fetal and early postnatal ...
R, Sugars +5 more
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Chicken HMGB1 Monoclonal Antibody
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017openaire +2 more sources
Nihon rinsho. Japanese journal of clinical medicine, 2005
Ikuro, Maruyama, Shingo, Yamada
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Ikuro, Maruyama, Shingo, Yamada
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