Results 61 to 70 of about 6,905 (159)

Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells. [PDF]

PLoS ONE, 2014
Respiratory syncytial virus (RSV) and human Metapneumovirus (hMPV), viruses belonging to the family Paramyxoviridae, are the most important causes of lower respiratory tract infection in young children.
Meera R Gupta, Deepthi Kolli, Claudio Molteni, Antonella Casola, Roberto P Garofalo   +4 more
doaj   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model

Pathogens, 2015
Human Metapneumovirus (hMPV) is a leading respiratory viral pathogen associated with bronchiolitis, pneumonia, and asthma exacerbation in young children, the elderly and immunocompromised individuals.
Nagarjuna R. Cheemarla, Antonieta Guerrero-Plata   +1 more
doaj   +1 more source

A Phase II Pilot Study of Anti‐PD‐L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple‐Negative Breast Cancer With or Without Germline BRCA Mutation

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Immunostimulatory effects of PARP inhibitors could increase sensitivity to immune checkpoint inhibitors. The previous Phase II trial (MEDIOLA) reported clinical benefits of durvalumab and olaparib (D + O) in patients with germline BRCA‐mutated (gBRCAm) HER2‐negative metastatic breast cancer.
Takeo Fujii, Ashley Cimino‐Mathews, Stanley Lipkowitz, Min‐Jung Lee, Jayakumar Nair, Britanny Brooke Solarz, Alexandra Zimmer, Bernadette Redd, Elliot B. Levy, Shraddha Rastogi, Nahoko Sato, Ann McCoy, Seth M. Steinberg, Jung‐Min Lee   +13 more
wiley   +1 more source

Clinical features and genomic characteristics of post-pandemic human metapneumovirus infections in hospitalized Taiwanese children

Journal of Microbiology, Immunology and Infection
Objects: Human metapneumovirus (HMPV) is a well-recognized respiratory viral pathogen and contributes to significant disease burden among children and high-risk populations.
Chun Yi Lee, Tsung Hua Wu, Yu Ping Fang, Jih Chin Chang, Hung Chun Wang, Shou Ju Lin, Yen Ray Huang, Yu Chuan Chang   +7 more
doaj   +1 more source

The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges

Advanced Genetics, Volume 6, Issue 4, December 2025.
This article examines how the respiratory virome contributes to health and disease, highlighting its interactions with the host and bacteriome. Key disease associations and present knowledge gaps are outlined. The review discusses challenges in sample collection and preprocessing, and presents future research directions for understanding virome ...
Xiaoxuan Yao, Xiaohui Zou, Bin Cao
wiley   +1 more source

Human metapneumovirus infection of organoid-derived human bronchial epithelium represents cell tropism and cytopathology as observed in in vivo models

mSphere
Human metapneumovirus (HMPV), a member of the Pneumoviridae family, causes upper and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly been performed in monolayers of undifferentiated epithelial cells.
Pau Ribó-Molina, Stefan van Nieuwkoop, Anna Z. Mykytyn, Peter van Run, Mart M. Lamers, Bart L. Haagmans, Ron A. M. Fouchier, Bernadette G. van den Hoogen   +7 more
doaj   +1 more source

A Re-emerging Respiratory Virus: Human Metapneumovirus (hMPV)

Cureus
Human metapneumovirus (hMPV) is identified as a pathogenic agent responsible for respiratory tract infections in paediatric, adult and elderly populations. It is a spherical, enveloped virus with a diameter of 209nm, consisting of a single-stranded, non-segmented, and negative-sense RNA genome of around 13.3 kb in length.
Mishra, Baijayantimala, Mohapatra, Diksha, Tripathy, Manisha, Mamidi, Prabhudutta, Mohapatra, Prasanta R   +4 more
openaire   +2 more sources

Comparison of Sofia 2 Respiratory Syncytial Virus Fluorescent Immunoassay to Real‐Time Polymerase Chain Reaction Assay in Children Under Two Years Old Hospitalized With Acute Respiratory Illness in Amman, Jordan: A Cross‐Sectional Study

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection (ARI) in children, particularly in low‐ and middle‐income countries. Rapid diagnosis is important for management and infection control. We aimed to evaluate diagnostic accuracy of Sofia 2 RSV fluorescent immunoassay (FIA) compared to reverse‐
Olla Hamdan, Justin Z. Amarin, Ahmad Yanis, Zaid Haddadin, Danielle A. Rankin, Yanal Shawareb, Haya Hayek, Tess Stopczynski, Molly Potter, Ahmad Alhajajra, Najwa Khuri‐Bulos, John Tamerius, Sushruth Reddy, Andrew J. Spieker, James D. Chappell, Natasha B. Halasa   +15 more
wiley   +1 more source

Human Metapneumovirus Establishes Persistent Infection in Lung Microvascular Endothelial Cells and Primes a Th2-Skewed Immune Response

Microorganisms, 2020
Human Metapneumovirus (HMPV) is a major cause of lower respiratory tract infections. HMPV infection has been hypothesized to alter dendritic cell (DC) immune response; however, many questions regarding HMPV pathogenesis within the infected lung remain ...
Antonella Bugatti, Stefania Marsico, Manuela Fogli, Sara Roversi, Serena Messali, Daniela Bosisio, Cinzia Giagulli, Arnaldo Caruso, Silvano Sozzani, Simona Fiorentini, Francesca Caccuri   +10 more
doaj   +1 more source