Results 81 to 90 of about 2,894 (131)

Human metapneumovirus (HMPV): A brief overview [PDF]

Human metapneumovirus (HMPV), discovered in 2001, is a significant respiratory pathogen in the Paramyxoviridae family that is responsible for substantial global morbidity and mortality.
Ansori, Arif Nur Muhammad
core   +1 more source

A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein

mBio
Human metapneumovirus (hMPV) is a leading cause of viral lower respiratory tract disease in children and adults. The hMPV fusion protein F is a trimeric class I fusion protein that is initially synthesized as a precursor (F0) and requires proteolytic ...
Marlies Ballegeer, Revina C. van Scherpenzeel, Teresa Delgado, Maria Iglesias-Caballero, Blanca García Barreno, Shubham Pandey, Scott A. Rush, Joost A. Kolkman, Vicente Mas, Jason S. McLellan, Xavier Saelens   +10 more
doaj   +1 more source

Human Metapneumovirus Establishes Persistent Infection in Lung Microvascular Endothelial Cells and Primes a Th2-Skewed Immune Response

Microorganisms, 2020
Human Metapneumovirus (HMPV) is a major cause of lower respiratory tract infections. HMPV infection has been hypothesized to alter dendritic cell (DC) immune response; however, many questions regarding HMPV pathogenesis within the infected lung remain ...
Antonella Bugatti, Stefania Marsico, Manuela Fogli, Sara Roversi, Serena Messali, Daniela Bosisio, Cinzia Giagulli, Arnaldo Caruso, Silvano Sozzani, Simona Fiorentini, Francesca Caccuri   +10 more
doaj   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, Volume 13, Issue 33, 15 June 2026.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Replication kinetics of HMPV and SH deletion mutants.

, 2013
Vero-118 cells were inoculated at a MOI of 0.1 with HMPV (closed circle), HMPVΔSH (open circle), HMPV-GFP (closed triangle down) and HMPVΔSH-GFP (open triangle down). Supernatants were collected daily and virus titres were determined by plaque assay.
Theo M. Luider (242944), Maarten Bijl (385936), Bob J. Scholte (292255), Wilfred van IJcken (42505), Albert D. M. E. Osterhaus (138961), Arno C. Andeweg (253554), Peter C. Burgers (242935), Jamil Aarbiou (385934), Eefje J. A. Schrauwen (343088), Sander Herfst (327462), Miranda de Graaf (138976), Fatiha Zaaraoui-Boutahar (385935), Ron A. M. Fouchier (169412)   +12 more
core   +1 more source

Epidemiological and clinical features of hMPV, RSV and RVs infections in young children.

, 2007
International audienceBACKGROUND: Human metapneumovirus (hMPV) has recently been isolated from children with acute respiratory tract infections (RTIs).
Aho, Serge-Ludwig, Espinosa, Sophie, Pothier, Pierre, Manoha, Catherine, Huet, Frédéric   +4 more
core   +1 more source

A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge

, 2017
Human metapneumovirus (hMPV) infections pose a serious health risk to young children, particularly in cases of premature birth. No licensed vaccine exists and there is no standard treatment for hMPV infections apart from supportive hospital care.
Toru Takimoto, Tripp, Ralph A., Jones, Bart G., Bart G. Jones, Robert E. Sealy, Ralph A. Tripp, Julia L. Hurwitz, Charles J. Russell, Mason, John N., Hurwitz, Julia L., Sealy, Robert E., Sherri L. Surman, John N. Mason, Randall T. Hayden, Hayden, Randall T., Russell, Charles J., Surman, Sherri L., Takimoto, Toru   +17 more
core   +1 more source

Live human metapneumovirus vaccine candidates attenuated by temperature sensitivity mutations from human respiratory syncytial virus

Journal of Virology
Human metapneumovirus (HMPV, genus Metapneumovirus) and respiratory syncytial virus (HRSV, genus Orthopneumovirus) are pediatric respiratory pathogens of the Pneumoviridae family. We previously developed live-intranasal HRSV vaccine candidates attenuated
Pramila Lamichhane, Lijuan Yang, Celia Santos, Hong-Su Park, Li Ou, Tongqing Zhou, Cyril Le Nouën, Ursula J. Buchholz   +7 more
doaj   +1 more source

Clinical data and comparison between HMPV and rhinovirus single infections.

, 2017
Clinical data and comparison between HMPV and rhinovirus single infections.
Maria del Mar Molinero (3841918), Cristina Calvo (765807), María Luz García-García (765808), Inmaculada Casas (103877), Cristina Rey (3841915), Beatriz Díaz (576442), Francisco Pozo (103855)   +6 more
core   +1 more source

Human metapneumovirus: pathogenesis, epidemiology, diagnostic technologies, and potential intervention strategies

Virology Journal
Human metapneumovirus (HMPV) is a notable viral pathogen that is responsible for respiratory tract infections in infants, young children, elderly individuals, and immunocompromised individuals.
Guicai Gao, Ruihong Lin, Dongli Ma
doaj   +1 more source