Results 71 to 80 of about 8,846 (194)

Intraoperative hemodynamic imbalance quantification: clinical validation of heart rate to mean blood pressure ratio in predicting myocardial injury after noncardiac surgery

BMC Cardiovascular Disorders
Background The effects of isolated heart rate (HR) and mean blood pressure (MBP) on myocardial injury after noncardiac surgery (MINS) have been investigated, but the combined impact of intraoperative HR and MBP remains unclear. This study aimed to assess
Yuanjun Zhou, Weiming Chen, Fei Liang, Liping Zhong, Yilin Liao, Yuting Zhong   +5 more
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Enhancing the Quality of Functional Home Meal Replacement Sweet Pumpkin Porridge

Journal of Food Quality
This study aimed to develop a functional home meal replacement (HMR) sweet pumpkin porridge by enhancing the content of carotenoids, the naturally abundant antioxidant nutrients in sweet pumpkin, and fortifying it with calcium and vitamin D, which are ...
So-Hui Shin, Ju-Hyun Park, Seyoung Ju, Kyung-Jin Yeum   +3 more
doaj   +1 more source

The Role of Fire Safety in Advancing United Nations Sustainable Development Goals: A Review

Sustainable Development, EarlyView.
ABSTRACT Fire safety is an essential yet often overlooked component of sustainable development. As urbanization accelerates and climate‐related hazards intensify, integrating fire risk reduction into sustainability frameworks is becoming increasingly critical. This review employs a structured narrative methodology, synthesizing peer‐reviewed literature
Mohammad R. Hassan
wiley   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

Metal‐free Hydrogen Generation from Seawater and Silicon Waste: A Circular Approach

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
Hydrogen was rapidly generated directly from untreated seawater and polymeric Si waste without any transition metal catalyst. The in situ generated polymeric cross‐linked Si resin was completely depolymerized under mild conditions into chloro‐silane monomers.
Mustapha Hamdaoui, Anja Steinmaurer, Philipp Jernej, Daniel Legenstein, Peter Hartmann, Adrian Daniel Boese, Katalin Barta   +6 more
wiley   +2 more sources

Single cell visualization of yeast gene expression shows correlation of epigenetic switching between multiple heterochromatic regions through multiple generations.

PLoS Biology, 2013
Differences in gene expression between individual cells can be mediated by epigenetic regulation; thus, methods that enable detailed analyses of single cells are crucial to understanding this phenomenon.
Yasunobu Mano, Tetsuya J Kobayashi, Jun-Ichi Nakayama, Hiroyuki Uchida, Masaya Oki   +4 more
doaj   +1 more source

Survival outcomes and treatment patterns in myelofibrosis in the JAK inhibitor era

British Journal of Haematology, EarlyView.
Summary Data on real‐world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients.
Juan‐Carlos Hernández‐Boluda, Eduardo Arellano‐Rodrigo, Manuel Pérez‐Encinas, José‐María Raya, María‐Teresa Gómez‐Casares, Francisca Ferrer‐Marín, Alberto Hernández‐Sánchez, María‐Laura Fox, Anna Angona, Beatriz Cuevas, María‐Isabel Mata‐Vázquez, Rosa Ayala, Natalia de las Heras, Elvira Mora, Valentín García‐Gutiérrez, Alicia Senín, Jasson Villarreal, Blanca Xicoy, Raúl Pérez‐López, María García‐Fortes, Sonia González de Villambrosia, Elena Magro, María‐José Ramírez, Paula Gómez, Angel Ramírez‐Payer, Clara Martínez‐Valverde, Lucía Pérez‐Lamas, Carmen García‐Hernández, Mercedes Gasior, Luis‐Miguel Juárez‐Salcedo, Francisco Ibáñez, María‐Luisa Antelo, Lucía Guerrero, Alberto Alvarez‐Larrán, Arturo Pereira, on behalf of the Spanish MPN Group (GEMFIN)   +35 more
wiley   +1 more source

Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide [PDF]

Journal of Antimicrobial Chemotherapy, 2003
Telithromycin (HMR 3647) is the first ketolide introduced into clinical practice. Ketolides are semisynthetic derivates of erythromycin A that carry novel biological properties on the erythronolide A ring. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. Ketolides
Grit, Ackermann, Arne C, Rodloff
openaire   +2 more sources

Enhancement of Motor Skill Development in Dental Education Through an Art‐Based Course, Including the COVID‐19 Period

European Journal of Dental Education, EarlyView.
ABSTRACT Background Modern higher education requires a redefinition of pedagogical objectives to meet the evolving cognitive and perceptual demands of contemporary students. One such emerging objective is the cultivation of visual perceptions. Generational differences suggest that current students possess distinct cognitive profiles and learning ...
Adrienne Fazekas, Balazs Sandor, Gyula Marada, Timea Dergez, Krisztian Katona, Andrea Radacsi, Michael Rakan Haddad, Ildiko Szanto   +7 more
wiley   +1 more source