Results 91 to 100 of about 8,539 (162)

Identification and Functional Characterization of Alternative Transcripts of LncRNA HNF1A-AS1 and Their Impacts on Cell Growth, Differentiation, Liver Diseases, and in Response to Drug Induction

Non-Coding RNA
The long non-coding RNA (lncRNA) hepatocyte nuclear factor-1 alpha (HNF1A) antisense RNA 1 (HNF1A-AS1) is an important lncRNA for liver growth, development, cell differentiation, and drug metabolism.
Jing Jin, Le Tra Giang Nguyen, Andrew Wassef, Ragui Sadek, Timothy M. Schmitt, Grace L. Guo, Theodore P. Rasmussen, Xiao-bo Zhong   +7 more
doaj   +1 more source

The expression profile of the HNF1A gene in human, mouse and rat.

, 2013
The expression profile of the HNF1A gene in human, mouse and rat is given. The species is given on the X-axis and the relative quantification of each isoform relative to the B2M gene is given on the Y-axis.
Lorna W. Harries (336166), Anna L. Gloyn (146286), James E. Brown (369339)   +2 more
core   +1 more source

Glycosylation of plasma proteins in HNF1A–maturity onset diabetes of the young [PDF]

, 2017
Dijabetes mladih koji se javlja u odrasloj dobi (MODY, engl. maturity onset diabetes of the young) monogenski je tip dijabetesa, najčešće uzrokovan mutacijama u genu HNF1A.
Pavić, Tamara
core  

Gene expression profiling of molecular target genes which are regulated by hepatocyte nuclear factor 1 Alpha (HNF1A) in rat insulin-secreting cells: role in HNF1A-MODY

, 2009
In this project, we were interested in studying HNF1A-induced defects in the expression of genes involved in the differentiation and regeneration of beta-cells in a cellular model of HNFlA-maturity-onset-diabetes-of-the-young(HNF1A-MODY), as well as the ...
Caroline Bonner (3124185)
core   +1 more source

HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

Nature Communications
HNF4A and HNF1A encode transcription factors that are important for the development and function of the pancreas and liver. Mutations in both genes have been directly linked to Maturity Onset Diabetes of the Young (MODY) and type 2 diabetes (T2D) risk ...
Natasha Hui Jin Ng, Soumita Ghosh, Chek Mei Bok, Carmen Ching, Blaise Su Jun Low, Juin Ting Chen, Euodia Lim, María Clara Miserendino, Yaw Sing Tan, Shawn Hoon, Adrian Kee Keong Teo   +10 more
doaj   +1 more source

Clinical and cellular characterisation of HNF1A transcription factor variants in people with young-onset diabetes

HNF1A-MODY, is a common form of monogenic diabetes. HNF1A variants of unknown significance can be a challenge to pathogenic, and in turn may prevent a diagnosis of HNF1A-MODY.
Cherkaoui, Ines
core   +1 more source

The association of HNF1A gene methylation with protein glycosylation in pancreatic adenocarcinoma and diabetes [PDF]

, 2018
Protein HNF1A je transkripcijski faktor mnogih glikoziltransferaza, a njegova poremećena ekspresija povezana je s promijenjenom glikozilacijom proteina te pojavom duktalnog adenokarcinoma gušterače i dijabetesa.
Bečeheli, Ivona
core  

HNF1A is a novel BRD4 target and critical for BET-inhibitor response in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an exceedingly lethal cancer that lacks actionable molecular drivers. We previously identified the transcription factor, HNF1A, as a novel driver of tumorigenesis, stemness, and metastasis in PDAC; however ...
Agnieszka K. Witkiewicz, Erik S. Knudsen, Ethan V. Abel, Bharani Muppavarapu, Evan Torres, Mark D. Long, Kennedy S. Humphrey, Katherine J. Crawford, Melanie M. Mayberry, Jianxin Wang, William Morris   +10 more
core   +1 more source

CRISPR/Cas9-based repair of a heterozygous HNF1A mutation in patient-derived hiPSCs. [PDF]

Hum Genet
Skoczek D, Hohendorff J, Malecki MT, Roig-Merino A, Bak RO, Kachamakova-Trojanowska N.   +5 more
europepmc   +1 more source

Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease. [PDF]

Genes Dev
Warin J, Grapin-Botton A.
europepmc   +1 more source