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A class act: conservation of homeodomain protein functions
Development, 1994ABSTRACT Dramatic successes in identifying vertebrate homeobox genes closely related to their insect relatives have led to the recognition of classes within the homeodomain superfamily. To what extent are the homeodomain protein classes dedicated to specific functions during development?
J R, Manak, M P, Scott
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Regulation of TFF3 expression by homeodomain protein CDX2
Regulatory Peptides, 2007Although trefoil factor family 3 (TFF3) plays an important role in protecting the intestinal mucosa, the regulatory mechanisms of its expression are not fully understood. Since homeodomain protein CDX2 has been reported to be critically involved in the development and differentiation of intestinal epithelium, we examined whether CDX2 affects the ...
Tadahito, Shimada +4 more
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Regulation of the HNF-1 homeodomain proteins by DCoH
Current Opinion in Genetics & Development, 1993The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which confers transcriptional activity to
L P, Hansen, G R, Crabtree
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Intracellular Trafficking and Dynamics of Double Homeodomain Proteins
Biochemistry, 2005Double homeodomain (DUX) proteins are encoded by a family of 3.3-kilobase repeated elements dispersed in the human genome. One of these elements named D4Z4 is found in a tandem repeat array on chromosome 4 that is partially deleted in facioscapulohumeral muscular dystrophy.
Östlund, Cecilia +3 more
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RNA recognition and translational regulation by a homeodomain protein
Nature, 1996In Drosophila, the primary determinant of anterior pattern is the gradient morphogen bicoid (bcd), a homeodomain protein that binds DNA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bcd also binds RNA and acts as a translational repressor to generate an opposing gradient of the ...
J, Dubnau, G, Struhl
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zhx-1:A Novel Mouse Homeodomain Protein Containing Two Zinc-Fingers and Five Homeodomains
Biochemical and Biophysical Research Communications, 1996A cDNA encoding the complete reading frame of a novel homeodomain-containing protein, named zhx-1, has been cloned from a mouse bone marrow stromal cell line. The ORF encodes a protein of 873 amino acids, in which two C2-H2 zinc-fingers and five homeodomains have been identified.
I, Barthelemy +5 more
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How to bridle a homeodomain protein
2010In plants, selective cell-to-cell transport of proteins is provided by the symplasmic pathway, the plasmodesmata. The presence of specific proteins, like the homeodomain transcription factors Zm KNOTTED1 (KN1) and At SHOOTMERISTEMLES (STM), is required for correct development and maintenance of different tissues and therefore essential for plant ...
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Homeodomain Proteins: Homeotic genes seek partners
Current Biology, 1994The interactions of one homeodomain protein with another may be a general way in which their specificity is enhanced.
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