Results 181 to 190 of about 41,966 (223)
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Homeodomain proteins and the regulation of gene expression
Current Opinion in Cell Biology, 1990The homeobox (HB), a 180 bp DNA sequence element, was first identified as a region of sequence similarity between homeotic genes and several other genes involved in the control of Drasc@ih development (McGinnis et al, Nature 1984, 308:428-433; Scott and Weiner, Proc NatlAcudSci CBA 1984, 81:411H119).
Michael Affolter +2 more
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1998
Abstract As described in Chapter 3, homeodomain proteins are transcription factors that are characterized by the presence of a 60-amino-acid DNA binding domain. The structure of the homeodomain consists of a flexible amino-terminal arm followed by three a helices (Fig.
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Abstract As described in Chapter 3, homeodomain proteins are transcription factors that are characterized by the presence of a 60-amino-acid DNA binding domain. The structure of the homeodomain consists of a flexible amino-terminal arm followed by three a helices (Fig.
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The homeodomain-containing proteins
Biochemical Pharmacology, 1999Alain Chariot +2 more
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Molecular interactions between homeodomain proteins [PDF]
, 2000 During embryogenesis, patterning is one of the key processes by which the body plan of the embryo becomes established. Patterning of the A-P axis is accomplished by the products of the Hox gene family. In mammals, there are 39 genes in the Hox family that have been grouped into four clusters (A-D) by virtue of their chromosome location.
Shanmugam, Kandavel.
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In vitrointeractions between barley TALE homeodomain proteins suggest a role for protein-protein associations in the regulation ofKnoxgene function [PDF]
Plant Journal, 2001 This paper describes two-hybrid interactions amongst barley homeodomain proteins encoded by the Three Amino acid Loop Extension (TALE) superfamily. The class I KNOX protein BKN3 is shown to homodimerise and to associate withproteins encoded by the class ...
Francesco Salamini +2 more
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Purification of the proline-rich homeodomain protein
Journal of Chromatography B, 2003The proline-rich homeodomain protein (PRH), also known as Hex, is a transcriptional repressor expressed in a variety of cell types. The PRH protein contains a proline-rich N-terminal domain that can repress transcription when attached to a heterologous DNA binding domain, a central homeodomain that mediates sequence-specific DNA binding, and an acidic ...
Butcher, AJ, Gaston, K, Jayaraman, P-S
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Target genes of homeodomain proteins
BioEssays, 1999Homeodomain proteins are transcription factors that share a related DNA binding domain, the homeodomain. This class of proteins was first recognized in the fruitfly Drosophila melanogaster where they cause homeotic transformations such as a fly with four wings instead of two (Lewis EB. A gene complex controlling segmentation in Drosophila.
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Identification of the Transactivating Region of the Homeodomain Protein, Hex
Journal of Biochemistry, 2004The homeodomain-containing protein Hex acts as an activator as well as a repressor of transcription in animals. While its repression domain has been mapped to the amino-terminal region, the activation domain has never been identified. Here, we show that the homeodomain and the acidic carboxyl-terminal region are necessary for full activation of the ...
Shinya, Kasamatsu +8 more
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Homeodomain Proteins in Pancreas Development
2001The pancreas derives from the upper, duodenal part of the foregut via a dorsal and ventral protrusion of the epithelium directly posterior to the developing stomach, and in the mouse, the early pancreatic buds become evident on embryonic day 9 (e9) (Figure 1). The part of the gut from which the pancreas originates becomes committed to a pancreatic fate
Ulf Ahlgren, Helena Edlund
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