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LIM homeodomain proteins and associated partners: Then and now
2021The field of molecular embryology started around 1990 by identifying new genes and analyzing their functions in early vertebrate embryogenesis. Those genes encode transcription factors, signaling molecules, their regulators, etc. Most of those genes are relatively highly expressed in specific regions or exhibit dramatic phenotypes when ectopically ...
Yuuri, Yasuoka, Masanori, Taira
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A Role for the HOXB7 Homeodomain Protein in DNA Repair
Cancer Research, 2007Abstract Homeobox genes encode transcription factors which function in body axis patterning in the developing embryo. Recent evidence suggests that the maintenance of specific HOX expression patterns is necessary for regulating the homeostasis of adult tissues as well.
Ethel, Rubin +12 more
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A class act: conservation of homeodomain protein functions
Development, 1994ABSTRACT Dramatic successes in identifying vertebrate homeobox genes closely related to their insect relatives have led to the recognition of classes within the homeodomain superfamily. To what extent are the homeodomain protein classes dedicated to specific functions during development?
J R, Manak, M P, Scott
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DNA Wrapping and Distortion by an Oligomeric Homeodomain Protein
Journal of Molecular Biology, 2008Many transcription factors alter DNA or chromatin structure. Changes in chromatin structure are often brought about by the recruitment of chromatin-binding proteins, chromatin-modifying proteins, or other transcription co-activator or co-repressor proteins.
Williams, H, Jayaraman, P-S, Gaston, K
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Regulation of TFF3 expression by homeodomain protein CDX2
Regulatory Peptides, 2007Although trefoil factor family 3 (TFF3) plays an important role in protecting the intestinal mucosa, the regulatory mechanisms of its expression are not fully understood. Since homeodomain protein CDX2 has been reported to be critically involved in the development and differentiation of intestinal epithelium, we examined whether CDX2 affects the ...
Tadahito, Shimada +4 more
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Regulation of the HNF-1 homeodomain proteins by DCoH
Current Opinion in Genetics & Development, 1993The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which confers transcriptional activity to
L P, Hansen, G R, Crabtree
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Intracellular Trafficking and Dynamics of Double Homeodomain Proteins
Biochemistry, 2005Double homeodomain (DUX) proteins are encoded by a family of 3.3-kilobase repeated elements dispersed in the human genome. One of these elements named D4Z4 is found in a tandem repeat array on chromosome 4 that is partially deleted in facioscapulohumeral muscular dystrophy.
Östlund, Cecilia +3 more
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Expression of homeodomain protein CDX2 in gallbladder carcinomas
Journal of Cancer Research and Clinical Oncology, 2005Caudal-related homeobox protein CDX2 plays an important role in the regulation of cell proliferation and differentiation of the intestinal epithelium. CDX2 is associated with intestinal metaplasia and carcinomas of the stomach, but the role of CDX2 in gallbladder carcinogenesis remains unknown.We analyzed the expression of CDX2 and intestinal apomucin ...
Xiang-Song, Wu +9 more
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RNA recognition and translational regulation by a homeodomain protein
Nature, 1996In Drosophila, the primary determinant of anterior pattern is the gradient morphogen bicoid (bcd), a homeodomain protein that binds DNA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bcd also binds RNA and acts as a translational repressor to generate an opposing gradient of the ...
J, Dubnau, G, Struhl
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