Results 191 to 200 of about 65,874 (228)

Target genes of homeodomain proteins

BioEssays, 1999
Homeodomain proteins are transcription factors that share a related DNA binding domain, the homeodomain. This class of proteins was first recognized in the fruitfly Drosophila melanogaster where they cause homeotic transformations such as a fly with four wings instead of two (Lewis EB. A gene complex controlling segmentation in Drosophila.
openaire   +2 more sources

Identification of the Transactivating Region of the Homeodomain Protein, Hex

Journal of Biochemistry, 2004
The homeodomain-containing protein Hex acts as an activator as well as a repressor of transcription in animals. While its repression domain has been mapped to the amino-terminal region, the activation domain has never been identified. Here, we show that the homeodomain and the acidic carboxyl-terminal region are necessary for full activation of the ...
Shinya, Kasamatsu, Ayuko, Sato, Taichi, Yamamoto, Vincent W, Keng, Hiroshi, Yoshida, Yuka, Yamazaki, Masafumi, Shimoda, Jun-ichi, Miyazaki, Tamio, Noguchi   +8 more
openaire   +2 more sources

LIM homeodomain proteins and associated partners: Then and now

2021
The field of molecular embryology started around 1990 by identifying new genes and analyzing their functions in early vertebrate embryogenesis. Those genes encode transcription factors, signaling molecules, their regulators, etc. Most of those genes are relatively highly expressed in specific regions or exhibit dramatic phenotypes when ectopically ...
Yuuri, Yasuoka, Masanori, Taira
openaire   +2 more sources

A Role for the HOXB7 Homeodomain Protein in DNA Repair

Cancer Research, 2007
Abstract Homeobox genes encode transcription factors which function in body axis patterning in the developing embryo. Recent evidence suggests that the maintenance of specific HOX expression patterns is necessary for regulating the homeostasis of adult tissues as well.
Ethel, Rubin, Xinyan, Wu, Tao, Zhu, Joyce C Y, Cheung, Hexin, Chen, Annaka, Lorincz, Raj K, Pandita, Girdhar G, Sharma, Hyo Chol, Ha, Judith, Gasson, Les A, Hanakahi, Tej K, Pandita, Saraswati, Sukumar   +12 more
openaire   +2 more sources

A class act: conservation of homeodomain protein functions

Development, 1994
ABSTRACT Dramatic successes in identifying vertebrate homeobox genes closely related to their insect relatives have led to the recognition of classes within the homeodomain superfamily. To what extent are the homeodomain protein classes dedicated to specific functions during development?
J R, Manak, M P, Scott
openaire   +2 more sources

DNA Wrapping and Distortion by an Oligomeric Homeodomain Protein

Journal of Molecular Biology, 2008
Many transcription factors alter DNA or chromatin structure. Changes in chromatin structure are often brought about by the recruitment of chromatin-binding proteins, chromatin-modifying proteins, or other transcription co-activator or co-repressor proteins.
Williams, H, Jayaraman, P-S, Gaston, K
openaire   +3 more sources

Regulation of TFF3 expression by homeodomain protein CDX2

Regulatory Peptides, 2007
Although trefoil factor family 3 (TFF3) plays an important role in protecting the intestinal mucosa, the regulatory mechanisms of its expression are not fully understood. Since homeodomain protein CDX2 has been reported to be critically involved in the development and differentiation of intestinal epithelium, we examined whether CDX2 affects the ...
Tadahito, Shimada, Takero, Koike, Michiko, Yamagata, Masashi, Yoneda, Hideyuki, Hiraishi   +4 more
openaire   +2 more sources

Homeodomain Proteins in Pancreas Development

2001
The pancreas derives from the upper, duodenal part of the foregut via a dorsal and ventral protrusion of the epithelium directly posterior to the developing stomach, and in the mouse, the early pancreatic buds become evident on embryonic day 9 (e9) (Figure 1). The part of the gut from which the pancreas originates becomes committed to a pancreatic fate
Ulf Ahlgren, Helena Edlund
openaire   +1 more source

Regulation of the HNF-1 homeodomain proteins by DCoH

Current Opinion in Genetics & Development, 1993
The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which confers transcriptional activity to
L P, Hansen, G R, Crabtree
openaire   +2 more sources

Intracellular Trafficking and Dynamics of Double Homeodomain Proteins

Biochemistry, 2005
Double homeodomain (DUX) proteins are encoded by a family of 3.3-kilobase repeated elements dispersed in the human genome. One of these elements named D4Z4 is found in a tandem repeat array on chromosome 4 that is partially deleted in facioscapulohumeral muscular dystrophy.
Östlund, Cecilia, Garcia-Carrasquillo, Ruth M., Belayew, Alexandra, Worman, Howard J.   +3 more
openaire   +3 more sources