Results 91 to 100 of about 3,024,874 (379)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression

Acta Pharmaceutica Sinica B, 2020
Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity, which is closely associated with inflammation. Benzydamine (BA) has been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that ...
Han Saem Son, Jiae Lee, Hye In Lee, Narae Kim, You-Jin Jo, Gong-Rak Lee, Seong-Eun Hong, Minjeong Kwon, Nam Young Kim, Hyun Jin Kim, Jin Ha Park, Soo Young Lee, Woojin Jeong   +12 more
doaj   +1 more source

Osteoblast-Osteoclast Communication and Bone Homeostasis

Cells, 2020
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell ...
Jung-Min Kim, Chujiao Lin, Z. Stavre, M. Greenblatt, Jae-hyuck Shim   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA

Nature Communications
Bacteria have evolved various response systems to adapt to environmental stress. A protease-based derepression mechanism in response to DNA damage was characterized in Deinococcus, which is controlled by the specific cleavage of repressor DdrO by ...
Huizhi Lu, Zijing Chen, Teng Xie, Shitong Zhong, Shasha Suo, Shuang Song, Liangyan Wang, Hong Xu, Bing Tian, Ye Zhao, Ruhong Zhou, Yuejin Hua   +11 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Establishing a method for the cryopreservation of viable peripheral blood mononuclear cells in the International Space Station

npj Microgravity
The analysis of cells frozen within the International Space Station (ISS) will provide crucial insights into the impact of the space environment on cellular functions and properties.
Hiroto Ishii, Rin Endo, Sanae Hamanaka, Nobuyuki Hidaka, Maki Miyauchi, Naho Hagiwara, Takahisa Miyao, Tohru Yamamori, Tatsuya Aiba, Nobuko Akiyama, Taishin Akiyama   +10 more
doaj   +1 more source

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy. [PDF]

, 2018
Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined.
Adamo, Matthew A, Chang, Julia, Feustel, Paul, Gruenthal, Michael, Huang, Yunfei, Liao, Yuan, Mathern, Gary W, Mathur, Ramkumar, Mazurkiewicz, Joseph, Morgan, Shannon, Qian, Jiang, Ritaccio, Anthony L, Zhao, Xiaofeng, Zhu, Xinjun   +13 more
core   +2 more sources