Results 41 to 50 of about 391,608 (295)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Comprehensive analysis of renewable hybrid energy systems in highway tunnels
Frontiers in Energy ResearchIn order to explore the feasibility of a renewable hybrid energy system in highway tunnels, a scenario-coupled construction method for a highway tunnel renewable hybrid energy system is proposed.
Zhen Liao +6 more
doaj +1 more source
Homer Foundation - 2007 Annual Report [PDF]
, 2007 Contains mission statement, director's message, program information, financial statements, reports from the distributions and investment committees, grants list, donor information, and list of board ...
core
Ulysses’ crew or Circe? – the implications of advance directives in mental health for psychiatrists [PDF]
, 2004 No abstract ...
Dresser, Homer
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
United in Grief: Achilles, Alexander and Hadrian
New Classicists, 2019 The association between Achilles and Alexander the Great has been accepted based on a few slim pieces of literary evidence. By looking at the work of Andrew Stewart who reaffirms that Alexander imitated Achilles, and by picking apart the sources which he
Lauren Murphy
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Homer Foundation - 2006 Annual Report [PDF]
, 2006 Contains mission statement, board chair's and director's messages, program information, financial statements, reports from the distributions and investment committees, grants list, donors list, and list of board ...
core