Results 51 to 60 of about 2,694,024 (386)
Journal of Neuroscience, 2014 Angelman syndrome (AS) is caused by the loss of Ube3A, an ubiquitin ligase that commits specific proteins to proteasomal degradation. How this defect causes autism and other pathological phenotypes associated with AS is unknown. Long-term depression (LTD)
M. Pignatelli +12 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Ulysses’ crew or Circe? – the implications of advance directives in mental health for psychiatrists [PDF]
, 2004 No abstract ...
Dresser, Homer
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The COVID digital home assemblage: Transforming the home into a work space during the crisis [PDF]
, 2021 Ash Watson, Deborah Lupton, Mike Michael
openalex +1 more source
Comprehensive analysis of renewable hybrid energy systems in highway tunnels
Frontiers in Energy ResearchIn order to explore the feasibility of a renewable hybrid energy system in highway tunnels, a scenario-coupled construction method for a highway tunnel renewable hybrid energy system is proposed.
Zhen Liao +6 more
doaj +1 more source
Ψυχή, Θυμός, and Metaphor in Homer and Plato
, 2014 1. The scope of this paper This paper deals with the notions of ψυχή and θυμός both in Homer and in Plato (especially the Republic), and in particular with the importance of metaphor (especially personification) in both the Homeric and Platonic versions ...
D. Cairns
semanticscholar +1 more source
The Sequence Alignment/Map format and SAMtools
Bioinform., 2009 Summary: The Sequence Alignment/Map (SAM) format is a generic alignment format for storing read alignments against reference sequences, supporting short and long reads (up to 128 Mbp) produced by different sequencing platforms.
Heng Li +8 more
semanticscholar +1 more source
Small Depth Quantum Circuits [PDF]
, 2007 Small depth quantum circuits have proved to be unexpectedly powerful in comparison to their classical counterparts. We survey some of the recent work on this and present some open problems.National Security Agency; Advanced Research and Development ...
Bera, Debajyoti +2 more
core +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source