Results 31 to 40 of about 887 (261)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Choban operators in generalized ordered spaces

, 2013
In this paper we investigate generalized ordered (GO) spaces that have a flexible diagonal in the sense of Arhangel'skii (2009) [2]. Spaces with a flexible diagonal are generalizations of topological groups and include spaces that are continuously ...
Burke, Dennis, Lutzer, David, Bennett, Harold   +2 more
core   +1 more source

Uncertainty principle estimates for vector fields [PDF]

, 2001
We derive weighted norm estimates for integral operators of potential type and for their related maximal operators. These operators are generalizations of the classical fractional integrals and fractional maximal functions. The norm estimates are derived
Wheeden, Richard L., Pérez Moreno, Carlos   +1 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Topological Quantum Field Theory and the Geometric Langlands Correspondence [PDF]

, 2013
In the pioneering work of A. Kapustin and E. Witten, the geometric Langlands program of number theory was shown to be intimately related to duality of GL-twisted N=4 super Yang-Mills theory compactified on a Riemann surface. In this thesis, we generalize
Setter, Kevin Luke
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Generalized complex and Dirac structures on homogeneous spaces

Differential Geometry and its Applications, 2011
Preprint
openaire   +2 more sources

On Ricci Curvature of a Homogeneous Generalized Matsumoto Finsler Space

Mathematics, 2023
The characterization of Finsler spaces with Ricci curvature is an ancient and cumbersome one. In this paper, we have derived an expression of Ricci curvature for the homogeneous generalized Matsumoto change. Moreover, we have deduced the expression of Ricci curvature for the aforementioned space with vanishing the S-curvature. These findings contribute
Yanlin Li, Manish Kumar Gupta, Suman Sharma, Sudhakar Kumar Chaubey   +3 more
openaire   +2 more sources

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source