Results 131 to 140 of about 1,318,508 (390)

O009/#418 Next generation sequencing reveals a high prevalence of pathogenic mutations in homologous recombination DNA damage repair genes among patients with uterine sarcoma [PDF]

, 2022
Dimitrios Nasioudis, Nawar Latif, Emily Ko, Lori Cory, Ashley Haggerty, Sarah Kim, Mark A. Morgan, Fiona Simpkins, Robert Giuntoli   +8 more
openalex   +1 more source

PREQUAL: detecting non-homologous characters in sets of unaligned homologous sequences

Bioinform., 2018
Summary Phylogenomic datasets invariably contain undetected stretches of non-homologous characters due to poor-quality sequences or erroneous gene models.
S. Whelan, Iker Irisarri, Fabien Burki
semanticscholar   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Humoral and cellular immune durability of different COVID-19 vaccine platforms following homologous/heterologous boosters: one-year post vaccination

Frontiers in Immunology
IntroductionThe durability of Hybrid immunity induced by natural infection and/or COVID-19 vaccines and evidence supporting further booster vaccination are crucial factors for pandemic response, yet remain poorly understood.MethodsWe measured the ...
Maaweya Awadalla, Halah Z. AlRawi, Rahaf A. Henawi, Fawziya Barnawi, Haitham Alkadi, Ahmed Alyami, Ammar Alsughayir, Alyazeed S. Alsaif, Ayman Mubarak, Wael Alturaiki, Bandar Alosaimi   +10 more
doaj   +1 more source

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.

Cancer Research, 2006
Deficiency in either of the breast cancer susceptibility proteins BRCA1 or BRCA2 induces profound cellular sensitivity to the inhibition of poly(ADP-ribose) polymerase (PARP) activity.
N. Mccabe, N. Turner, C. Lord, Katarzyna Kluzek, A. Białkowska, S. Swift, Sabrina Giavara, M. O’Connor, A. Tutt, M. Zdzienicka, G. Smith, A. Ashworth   +11 more
semanticscholar   +1 more source

A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. [PDF]

, 2019
Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome at the site where the gRNA directs Cas9-mediated cleavage.
Bier, Ethan, Kulkarni, Surashree S, Nizet, Victor, Valderrama, J Andrés   +3 more
core   +1 more source

Contact surgeries and the transverse invariant in knot Floer homology [PDF]

, 2010
We study naturality properties of the transverse invariant in knot Floer homology under contact (+1)-surgery. This can be used as a calculational tool for the transverse invariant.
Ozsvath, Peter, Stipsicz, Andras
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Selective utilization of non‐homologous end‐joining and homologous recombination for DNA repair during meiotic maturation in mouse oocytes

, 2022
Crystal Lee, Jiyeon Leem, Jeong Su Oh
openalex   +1 more source

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

Nature Medicine, 2016
The corticospinal tract (CST) is the most important motor system in humans, yet robust regeneration of this projection after spinal cord injury (SCI) has not been accomplished.
K. Kadoya, P. Lu, K. Nguyen, Corinne A. Lee-Kubli, H. Kumamaru, Lin Yao, Joshua A. Knackert, G. Poplawski, J. Dulin, Hans Strobl, Y. Takashima, Jeremy S. Biane, J. Conner, Su-Chun Zhang, M. Tuszynski   +14 more
semanticscholar   +1 more source