Results 141 to 150 of about 1,306,827 (384)

Homologous non-isotopic symplectic tori in a K3-surface

, 2003
For each member of an infinite family of homology classes in the K3-surface E(2), we construct infinitely many non-isotopic symplectic tori representing this homology class. This family has an infinite subset of primitive classes.
B. DOUG PARK, Fintushel R., Thurston W. P., TOLGA ETGÜ   +3 more
core   +3 more sources

Engineering the Caenorhabditis elegans Genome Using Cas9-Triggered Homologous Recombination

Nature Methods, 2013
Study of the nematode Caenorhabditis elegans has provided important insights in a wide range of fields in biology. The ability to precisely modify genomes is critical to fully realize the utility of model organisms. Here we report a method to edit the C.
D. Dickinson, Jordan D. Ward, D. Reiner, B. Goldstein   +3 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

High homologous gene conservation despite extreme autopolyploid redundancy in sugarcane [PDF]

, 2011
Modern sugarcane (Saccharum spp.) has been recognized as one of the world's most efficient crops in solar energy conversion and as havlng the mast favorable input: output ratios. Beside ils importance for sugar production, ilthus became recently aprimary
Bocs, Stéphanie, Charron, Carine, D'Hont, Angélique, Droc, Gaëtan, Garsmeur, Olivier, Van Sluys, Marie-Anne   +5 more
core  

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]

, 2019
Ron D. Jachimowicz, Filippo Beleggia, Jörg Isensee, Bhagya Bhavana Velpula, Jonas Goergens, Matías A. Bustos, Markus Alexander Doll, Anjana Shenoy, Cintia Checa-Rodríguez, Janica L. Wiederstein, Keren Baranes‐Bachar, Christoph Bartenhagen, Falk Hertwig, Nizan Teper, Tomohiko Nishi, Anna Schmitt, Felix Distelmaier, Hermann‐Josef Lüdecke, Beate Albrecht, Marcus Krüger, Björn Schumacher, Tamar Geiger, Dave S.�B. Hoon, Pablo Huertas, Matthias Fischer, Tim Hucho, Martin Peifer, Yael Ziv, Hans Christian Reinhardt, Dagmar Wieczorek, Yosef Shiloh   +30 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Holding it together: DNA end synapsis during non-homologous end joining

, 2023
Joseph J. Loparo
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.

Cancer Research, 2006
Deficiency in either of the breast cancer susceptibility proteins BRCA1 or BRCA2 induces profound cellular sensitivity to the inhibition of poly(ADP-ribose) polymerase (PARP) activity.
N. Mccabe, N. Turner, C. Lord, Katarzyna Kluzek, A. Białkowska, S. Swift, Sabrina Giavara, M. O’Connor, A. Tutt, M. Zdzienicka, G. Smith, A. Ashworth   +11 more
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source