Results 271 to 280 of about 314,723 (346)

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

Modeling mammalian meiosis with pluripotent stem cells: progress and challenges. [PDF]

Clin Epigenetics
Yang F, Gu J, Chen H, Wang Y, Huang W, Chen X, Liu M, Yu X, Cp Cheung K.   +8 more
europepmc   +1 more source

CRISPR/Cas9 Genome Engineering in Non‐Conventional Oleaginous Yeasts: Applications, Challenges, and Prospects

Yeast, EarlyView.
ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias, Fernanda Pinheiro Moreira Freitas, Eduardo Luís Menezes de Almeida, Luciano Gomes Fietto, Agustin Zsögön, Wendel Batista da Silveira   +5 more
wiley   +1 more source

De Novo Chromosome-Level Genome Assembly of 'Qing Zhou Mi' Landrace Peach and Analysis of Late Maturity and Fruit Weight Traits in Peach. [PDF]

Plants (Basel)
Li M, Gong Q, Li G, Gao J, Zhang A.
europepmc   +1 more source

Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris

Integrative Zoology, EarlyView.
Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli, Al‐Sayed Al‐Soudy, Mariangela Norcia, Stefania Galdiero, Sara Palladino, Emanuela Cirillo, Gianluca Polese, Anna Di Cosmo   +7 more
wiley   +1 more source

Comparative genomic analysis of Artemisia argyi reveals asymmetric expansion of terpene synthases and conservation of artemisinin biosynthesis. [PDF]

Plant J
Chen X, Liao B, Wu D, Li C, Li Z, Huang Z, Duan L, Shen Q.   +7 more
europepmc   +1 more source

Comparative Satellitomics in Arowanas (Telostei, Osteoglossiformes) Sheds Light on the Evolution of Ancient Satellite DNAs

Integrative Zoology, EarlyView.
This work focused on arowana fishes (Teleostei, Osteoglossiformes) as a model; their widespread intercontinental distribution and basal phylogenetic position within Teleostei make them a compelling model for evolutionary research, especially in the realm of satDNA molecular evolution. Through the integration of genomic and chromosomal data, we analyzed
Fernando Henrique Santos de Souza, Gustavo Akira Toma, Jhon Alex Dziechciarz Vidal, Manuel Angel Garrido‐Ramos, Guilherme Mota Souza, Rodrigo Zeni Dos Santos, Fábio Porto‐Foresti, Thomas Liehr, Ricardo Utsunomia, Marcelo de Bello Cioffi   +9 more
wiley   +1 more source

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

Integrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao, Zhaowei Zhong, Lisheng Wu, Quanyin Liu, Shaoxiong Ding   +4 more
wiley   +1 more source

Synthetic rewriting technologies in mammalian cells. [PDF]

Nat Commun
Wang Y, Cui Y, Zhao GR, Wu Y, Yuan YJ.
europepmc   +1 more source

Genome Expansion of ZPB1(a) and ZPC1(a) in Basal Species or Liver Expression of ZPB1a and ZPC1aa in Advanced Species, Two Different Strategies to Ensure Sufficient ZP Synthesis in Teleosts

Integrative Zoology, EarlyView.
We found that teleosts employed two different strategies to ensure sufficient ZP (zona pellucida) synthesis: expansion of ZPB1(a) and ZPC1(a) in basal species or liver expression of ZPB1a and ZPC1aa in advanced species. The N‐terminus of expanded ZPB1(a) or ZPC1(a) and liver‐expressed ZPB1a contains repeated units or low‐complexity regions to form ...
Tian Gao, Suying Ma, Shiyi Zhang, Fan Bai, Lingyao Gan, Wenjing Tao, Feilong Wang, Deshou Wang, Lina Sun   +8 more
wiley   +1 more source