Results 1 to 10 of about 16,230 (221)

Rate of Homologous Desensitization and Internalization of the GLP-1 Receptor [PDF]

Molecules, 2016
The glucagon-like peptide-1 receptor (GLP-1R) is an important target in the treatment of type 2 diabetes mellitus. The aim of this study was to compare the rate of agonist stimulated desensitization and internalization of GLP-1R.
Ghina Shaaban, Mabayoje Oriowo, Suleiman Al-Sabah   +2 more
doaj   +7 more sources

Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells. [PDF]

PLoS ONE, 2012
Receptor desensitization is a ubiquitous regulatory mechanism that defines the activatable pool of receptors, and thus, the ability of cells to respond to environmental stimuli. In recent years, the molecular mechanisms controlling the desensitization of
Michelle B Henesy, Andrea L Britain, Bing Zhu, Lauren Amable, Richard E Honkanen, Jackie D Corbin, Sharron H Francis, Thomas C Rich   +7 more
doaj   +4 more sources

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]

Cell and Tissue Research, 2013
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of ...
A Faivre-Bauman, A Rathinavelu, AB Abou-Samra, Abir Mukherjee, AF Gilkes, AH Tashjian Jr, AM Hamad, Andrew J. Lessey, Andrew Sunters, AR Yoder, Bigboy Simbi, CA McArdle, CA McArdle, CA McArdle, Caroline P. Wheeler-Jones, Craig A. McArdle, D Fan, D Müller, DJ Hartt, DM Dickey, FN Zeytin, G Rousseau, Gary F. Baxter, GY Koh, H Chusho, H Hao, I Kishimoto, Iain R. Thompson, Imelda M. McGonnell, IR Thompson, IR Thompson, J Horvath, KN Pandey, KN Pandey, Lorna Smith, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, MA Vieira, Mark S. Roberson, MB Henesy, MJ Lopez, N Tamura, PM Hinkle, RC Fowkes, RC Fowkes, RC Fowkes, RC Fowkes, Robert C. Fowkes, S Inagaki, S Suga, SA Bayol, Samantha M. Mirczuk, SE Abbey, SE Abbey-Hosch, SE Abbey-Hosch, SW John, T Sudoh, Victoria J. Lipscomb, Y Komatsu, Y Shimekake   +65 more
core   +9 more sources

Does PKC activation increase the homologous desensitization of μ opioid receptors? [PDF]

Br J Pharmacol, 2015
Background and PurposeThis study examined the role of agents known to activatePKCon morphine‐induced desensitization of μ‐opioid receptors (MOPreceptors) in brain slices containing locus coeruleus neurons.Experimental ApproachIntracellular recordings were obtained from rat locus coeruleus neurons.
Arttamangkul S, Birdsong W, Williams JT.
europepmc   +5 more sources

α1B-adrenergic receptors differentially associate with Rab proteins during homologous and heterologous desensitization. [PDF]

PLoS ONE, 2015
Internalization of G protein-coupled receptors can be triggered by agonists or by other stimuli. The process begins within seconds of cell activation and contributes to receptor desensitization.
Jean A Castillo-Badillo, Omar B Sánchez-Reyes, Marco A Alfonzo-Méndez, M Teresa Romero-Ávila, Guadalupe Reyes-Cruz, J Adolfo García-Sáinz   +5 more
doaj   +5 more sources

Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. [PDF]

Am J Respir Cell Mol Biol, 2011
Bitter taste receptors (TAS2Rs) were shown to be expressed in human airway smooth muscle (ASM). They couple to specialized [Ca(2+)](i) release, leading to membrane hyperpolarization, the relaxation of ASM, and marked bronchodilation. TAS2Rs are G-protein-coupled receptors, known to undergo rapid agonist-promoted desensitization that can limit ...
Robinett KS, Deshpande DA, Malone MM, Liggett SB.   +3 more
europepmc   +6 more sources

TRAF6-mediated ubiquitination of AKT in the nucleus is a critical event underlying the desensitization of G protein-coupled receptors [PDF]

Cell Communication and Signaling
Background Desensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists.
Chengyan Wu, Li Hu, Bing Liu, Xingyue Zeng, Haixiang Ma, Yongkai Cao, Huijun Li, Xiaohan Zhang   +7 more
doaj   +2 more sources

Insulin Reverses Growth Hormone-induced Homologous Desensitization [PDF]

Journal of Biological Chemistry, 2006
Growth hormone (GH) is secreted in a pulsatile pattern to promote body growth and metabolism. GH exerts its function by activating several signaling pathways, including JAK2/STAT and MEK/ERK. ERK1/2 activation by GH plays important roles in gene expression, cell proliferation, and growth. We previously reported that in rat H4IIE hepatoma cells after an
Jie, Xu, Zhongyu, Liu, Thomas L, Clemens, Joseph L, Messina   +3 more
openaire   +3 more sources

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy [PDF]

, 2008
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies results from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2).
Ahmad, F, Banerjee, SK, Conner, DA, Huang, XN, Janczewski, AM, Keller, BB, Lage, ML, Mathier, MA, Moskowitz, IP, Perez-Atayde, AR, Rager, J, Saba, S, Seidman, CE, Seidman, JG, Shroff, SG, Smith, SH, Tinney, JP, Tobita, K   +17 more
core   +16 more sources

The rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocols. [PDF]

PLoS Computational Biology, 2011
The sensory-motor neuron synapse of Aplysia is an excellent model system for investigating the biochemical changes underlying memory formation. In this system, training that is separated by rest periods (spaced training) leads to persistent changes in ...
Faisal Naqib, Carole A Farah, Christopher C Pack, Wayne S Sossin   +3 more
doaj   +1 more source