Results 91 to 100 of about 16,230 (221)

How GPCRs Engage GPCR Kinases in the First Step of Homologous Desensitization [PDF]

, 2021
J.J.G. Tesmer, Qiuyan Chen, Manolo Plasencia, Zhuang Li, Leifu Chang, Philip Andrews   +5 more
openalex   +1 more source

Balancing Promise and Peril: Hemophilia Gene Therapy Insights

IUBMB Life, Volume 78, Issue 1, January 2026.
ABSTRACT Hemophilia is an inherited disorder characterized by impaired blood clotting caused by mutations in the genes responsible for producing coagulation factor (F) VIII (hemophilia A, HA) or FIX (hemophilia B, HB). Current treatment primarily relies on replacement therapy, involving frequent and costly infusions of FVIII or FIX concentrates.
Saicharan Akula, Ester Borroni, Alessia Cottonaro, Antonia Follenzi, Simone Merlin   +4 more
wiley   +1 more source

Evaluation of leptin treatment on maintenance of body weight loss in diet‐induced obese mice

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 401-416, January 2026.
Abstract Aims To evaluate the therapeutic potential of leptin treatment for weight loss maintenance preclinically, through a systematic evaluation of leptin efficacy (a) following a period of weight loss stability (as in published clinical studies), and (b) across a range of circulating leptin concentrations achieved through a variety of different ...
Danna M. Breen, Rocío M. Saavedra‐Peña, Stephanie Joaquim, Jimmy Kong, Ryan Reese, J. Brent Kuzmiski, John C. Stansfield, Rhys Jones, Kendra K. Bence, V. Margaret Jackson   +9 more
wiley   +1 more source

Homologous desensitization of the human guanylate cyclase C receptor

European Journal of Biochemistry, 2000
Guanylate Cyclase C (GCC) serves as a receptor for the endogenous ligands, guanylin and uroguanylin, as well as the family of bacterial heat‐stable enterotoxins (ST), which are one of the major causes of diarrhoea the world over. We had earlier provided evidence that GCC, present in the human colonic T84 cell line, is desensitized on prolonged exposure
Bakre, Manjiri M, Ghanekar, Yashoda, Visweswariah, Sandhya S   +2 more
openaire   +3 more sources

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science, Volume 12, Issue 45, December 4, 2025.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
wiley   +1 more source

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor I. Binding characteristics [PDF]

, 1994
Glimepiride is a novel sulfonylurea drug for treatment of non-insulin-dependent diabetes mellitus with higher blood sugar lowering efficacy in diabetic patients than glibenclamide raising the question whether this characteristics is in line with ...
Aguilar-Bryan, Ashcroft, Ashcroft, Benovic, Bhathena, Boyd, Boyd, Boyd, Carpentier, Chick, French, Gaines, Geisen, Geisen, Gerich, Gylfe, Kaubisch, Kolterman, Kramer, Kramer, Müller, Nelson, Nelson, Niki, Niki, Niki, Niki, Panten, Popov, Praz, Schmid-Antomarchi, Schmid-Antomarchi, Sturgess, Sugiura, Weiland, Yalow   +35 more
core   +1 more source

The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis [PDF]

, 2017
The scientific community will remember Peter Läuger as an exceptional man combining a generous personality and a sharp and skilful mind. He was able to attract by his views the interest of a large spectrum of biologists concerned by the mechanism of ion ...
Bertrand, Daniel, Changeux, Jean-Pierre, Devillers-Thiéry, Anne, Galzi, Jean-Luc   +3 more
core  

Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception [PDF]

, 2012
BACKGROUND: The Transient Receptor Potential (TRP) ion channel TRPA1 is a key player in pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N-terminal cysteines.
Barabas, Marie E, Batista-Schepman, Patricia A, Dinsmore, Thomas B, Foshage, Audra M, Harris, Eli Q, Kossyreva, Elena A, Schwab, Matthew J, Story, Gina M, Stucky, Cheryl L, Wang, Michelle H, Wang, Victoria M, Weng, Yingqi   +11 more
core   +2 more sources

The full repertoire of Drosophila gustatory receptors for detecting an aversive compound. [PDF]

, 2015
The ability to detect toxic compounds in foods is essential for animal survival. However, the minimal subunit composition of gustatory receptors required for sensing aversive chemicals in Drosophila is unknown.
Jeong, Yong Taek, Kim, Yonjung, Lee, Min Goo, Lee, Youngseok, Montell, Craig, Moon, Seok Jun, Shim, Jaewon   +6 more
core   +2 more sources

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. [PDF]

, 2020
G protein-coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus ...
Benovic, Jeffrey, Brass, Lawrence F., Chen, Xi, Cooper, Matthew, DeHelian, Daniel, Goldfinger, Lawrence E., Gupta, Shuchi, Ma, Peisong, McKenzie, Steven E., Naik, Meghna U., Naik, Ulhas P., Stalker, Timothy J., Wurtzel, Jeremy G.T., Zhao, Xuefei   +13 more
core   +1 more source