Results 171 to 180 of about 264,308 (203)
Some of the next articles are maybe not open access.
Homologous desensitization of the murine luteinizing hormone receptor expressed in L cells
Molecular and Cellular Endocrinology, 1995Using a clonal cell line that stably expresses the murine luteinizing hormone receptor (LHR 11/6 cells), we studied the molecular mechanisms of agonist-induced desensitization of the luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase.
T, Gudermann +2 more
openaire +2 more sources
The Journal of Pharmacology and Experimental Therapeutics, 1999
Acute desensitization of contraction and its relative mechanisms have been studied in smooth muscle cells isolated from guinea pig stomach. Desensitization was induced by pre-exposure of the cells to one of the excitatory neuropeptides linked to the phospholipase C intracellular cascade, i.e., cholecystokinin (CCK), gastrin-releasing peptide, and ...
SEVERI C +7 more
openaire +4 more sources
Acute desensitization of contraction and its relative mechanisms have been studied in smooth muscle cells isolated from guinea pig stomach. Desensitization was induced by pre-exposure of the cells to one of the excitatory neuropeptides linked to the phospholipase C intracellular cascade, i.e., cholecystokinin (CCK), gastrin-releasing peptide, and ...
SEVERI C +7 more
openaire +4 more sources
Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons.
Molecular Pharmacology, 1992Exposure of mouse colliculi neurons to selective 5-hydroxytryptamine (5-HT)4 agonists was accompanied by a rapid desensitization of the receptor-stimulated adenylyl cyclase response. Half-maximal desensitization occurred after 2 min. Only exposure of neurons to selective 5-HT4 agonists led to a potent desensitization of the 5-HT4-mediated response ...
H, Ansanay +3 more
openaire +2 more sources
Trends in Pharmacological Sciences, 1996
Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitization, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC).
Tsu Tshen Chuang +3 more
openaire +3 more sources
Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitization, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC).
Tsu Tshen Chuang +3 more
openaire +3 more sources
The Journal of Pharmacology and Experimental Therapeutics, 1998
The role of drug efficacy in agonist-induced desensitization was studied in C-6 glioma cells transfected with the monkey dopamine D1A (mD1A) receptor. Dopamine pretreatment for 2 hr produced greater than 80% loss of responsiveness in the stimulation of cAMP accumulation that was blocked by the D1 antagonist SCH23390.
M M, Lewis +4 more
openaire +2 more sources
The role of drug efficacy in agonist-induced desensitization was studied in C-6 glioma cells transfected with the monkey dopamine D1A (mD1A) receptor. Dopamine pretreatment for 2 hr produced greater than 80% loss of responsiveness in the stimulation of cAMP accumulation that was blocked by the D1 antagonist SCH23390.
M M, Lewis +4 more
openaire +2 more sources
Journal of Pharmacology and Experimental Therapeutics, 1988
Previous work from our laboratory demonstrated that RBL-1 cells express membrane receptors for leukotriene (LT)D4 and that agonist stimulation of these receptors results in mobilization of intracellular calcium ([Ca++]i).
J. Winkler, S. Mong, S. Crooke
semanticscholar +1 more source
Previous work from our laboratory demonstrated that RBL-1 cells express membrane receptors for leukotriene (LT)D4 and that agonist stimulation of these receptors results in mobilization of intracellular calcium ([Ca++]i).
J. Winkler, S. Mong, S. Crooke
semanticscholar +1 more source
Sequestered A431 cell β-adrenoceptors remain functional after homologous desensitization
Biochemical Pharmacology, 1988This study seeks to investigate the functional state of sequestered beta-adrenoceptors in A431 cells which have undergone homologous desensitization. Incubation of cells with isoprenaline under desensitizing conditions caused a reduction (a) in the number of cell surface beta-receptors as measured by 3H-CGP 12,177 binding, and (b) in the extent of ...
D, Cooney, A K, Keenan
openaire +2 more sources
Journal of Cellular Physiology, 1987
AbstractTreatment of murine peritoneal macrophages for 30 min with lipopolysaccharide (LPS) resulted in a transient increase in c‐fos proto‐oncogene mRNA levels (Introna et al., 1986). After 2 h from the initial treatment, c‐fos mRNA could no longer be detected and its expression could not be restimulated either by LPS or by other signals including ...
M, Introna +4 more
openaire +2 more sources
AbstractTreatment of murine peritoneal macrophages for 30 min with lipopolysaccharide (LPS) resulted in a transient increase in c‐fos proto‐oncogene mRNA levels (Introna et al., 1986). After 2 h from the initial treatment, c‐fos mRNA could no longer be detected and its expression could not be restimulated either by LPS or by other signals including ...
M, Introna +4 more
openaire +2 more sources
Acta Endocrinologica, 1993
Prolonged use of calcitonin (CT) in vivo leads to a loss of biological response (escape). To understand the molecular basis of this phenomenon, we examined desensitization of calcitonin receptors and down-regulation of adenylate cyclase response to CT in T47CD cells after a preincubation with CT. Preincubation with salmon or human CT (sCT, hCT) for 3 h
H G, Schneider +4 more
openaire +2 more sources
Prolonged use of calcitonin (CT) in vivo leads to a loss of biological response (escape). To understand the molecular basis of this phenomenon, we examined desensitization of calcitonin receptors and down-regulation of adenylate cyclase response to CT in T47CD cells after a preincubation with CT. Preincubation with salmon or human CT (sCT, hCT) for 3 h
H G, Schneider +4 more
openaire +2 more sources
Canadian Journal of Physiology and Pharmacology, 2006
The natriuretic peptide receptor-A (NPR-A) mediates natriuretic, hypotensive, and antihypertrophic effects of natriuretic peptides through the production of cGMP. In pathological conditions such as heart failure, these effects are attenuated by homologous and heterologous desensitization mechanisms resulting in the dephosphorylation of the cytosolic ...
Yann, Fortin, André, De Léan
openaire +2 more sources
The natriuretic peptide receptor-A (NPR-A) mediates natriuretic, hypotensive, and antihypertrophic effects of natriuretic peptides through the production of cGMP. In pathological conditions such as heart failure, these effects are attenuated by homologous and heterologous desensitization mechanisms resulting in the dephosphorylation of the cytosolic ...
Yann, Fortin, André, De Léan
openaire +2 more sources