Results 11 to 20 of about 264,308 (203)

Does PKC activation increase the homologous desensitization of μ opioid receptors? [PDF]

Br J Pharmacol, 2015
Background and PurposeThis study examined the role of agents known to activatePKCon morphine‐induced desensitization of μ‐opioid receptors (MOPreceptors) in brain slices containing locus coeruleus neurons.Experimental ApproachIntracellular recordings were obtained from rat locus coeruleus neurons.
Arttamangkul S, Birdsong W, Williams JT.
europepmc   +5 more sources

Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A. [PDF]

J Neuroinflammation, 2016
Acute exposure to prostaglandin E2 (PGE2) activates EP receptors in sensory neurons which triggers the cAMP-dependent protein kinase A (PKA) signaling cascade resulting in enhanced excitability of the neurons.
Malty RH, Hudmon A, Fehrenbacher JC, Vasko MR.   +3 more
europepmc   +4 more sources

The GnRH receptor and the response of gonadotrope cells to GnRH pulse frequency code. A story of an atypical adaptation of cell function relying on a lack of receptor homologous desensitization.

Folia Histochemica et Cytobiologica, 2010
Brain control of the reproductive system is mediated through hypothalamic gonadotropin-releasing hormone (GnRH) which activates specific receptors (GnRHR) present at the surface of the pituitary gonadotropes to trigger secretion of the two gonadotropins ...
Christian Bleux, Violaine Simon, Jean-NoĂŤl Laverriere, Ghislaine Garrel, Raymond Counis, Solange Magre, JoĂŤlle Cohen-Tannoudji   +6 more
doaj   +4 more sources

Insulin Reverses Growth Hormone-induced Homologous Desensitization [PDF]

Journal of Biological Chemistry, 2006
Growth hormone (GH) is secreted in a pulsatile pattern to promote body growth and metabolism. GH exerts its function by activating several signaling pathways, including JAK2/STAT and MEK/ERK. ERK1/2 activation by GH plays important roles in gene expression, cell proliferation, and growth. We previously reported that in rat H4IIE hepatoma cells after an
Jie, Xu, Zhongyu, Liu, Thomas L, Clemens, Joseph L, Messina   +3 more
semanticscholar   +4 more sources

Transient homologous mu-opioid receptor desensitization in rat locus coeruleus neurons [PDF]

The Journal of Neuroscience, 1991
Opioid agonists hyperpolarize neurons of the locus coeruleus (LC) in the slice preparation. When opioids were applied at concentrations that caused a maximum hyperpolarization, the membrane potential hyperpolarized to a peak (about 30 mV) in the first minute and then declined over a period of 5 min.
G. C. M. Harris, JT Williams
openalex   +4 more sources

Characterization of the homologous and heterologous desensitization of rat Leydig-tumour-cell adenylate cyclase [PDF]

Biochemical Journal, 1984
The homologous and heterologous desensitization of rat Leydig-tumour-cell adenylate cyclase induced by lutropin (LH) was characterized with the aid of forskolin and cholera toxin. Forskolin stimulated cyclic AMP production in a dose-dependent manner, with linear kinetics up to 2h.
C. J. Dix, A D Habberfield, B A Cooke
openalex   +4 more sources

Desensitization of the human V2 vasopressin receptor. Homologous effects in the absence of heterologous desensitization.

Journal of Biological Chemistry, 1992
Three main pathways have been implicated in desensitization of receptors that stimulate adenylylcyclase (AC): cAMP-mediated phosphorylation; cAMP-independent phosphorylation, and receptor internalization. Cell lines derived from the murine Ltk- cell were found useful in exploring the contribution of cAMP-dependent phosphorylation in V2 vasopressin ...
M Birnbaumer, Anaid Antaramián, Axel P. N. Themmen, S Gilbert   +3 more
openalex   +3 more sources

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]

Cell and Tissue Research, 2013
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of disrupted CNP and GC-B indicate a potential role in growth hormone secretion.
Thompson, Iain R, Mirczuk, Samantha M, Smith, Lorna, Lessey, Andrew J, Simbi, Bigboy, Sunters, Andrew, Baxter, Gary F, Lipscomb, Victoria J, McGonnell, Imelda M, Wheeler-Jones, Caroline P, Mukherjee, Abir, Roberson, Mark S, McArdle, Craig A, Fowkes, Robert C   +13 more
openaire   +4 more sources

Phosphorylation of the Prostacyclin Receptor during Homologous Desensitization [PDF]

Journal of Biological Chemistry, 1998
Emer M. Smyth, W. Hong Li, Garret A. FitzGerald   +2 more
openalex   +2 more sources

Homologous Desensitization of Histamine-Mediated Signal Transduction System in C6 Glioma Cells

The Chinese Journal of Physiology, 2013
Molecular events involved in the homologous desensitization of histamine-mediated signal transduction system in glioma cells are not well understood. The aim of this study was designed to gain further insight into possible events in the process using the C6 glioma cells. Incubation of histamine caused increases in inositol phosphate (IP1) formation and
Chin-Lu, Tseng, Jiann-Wu, Wei
openaire   +3 more sources