Results 11 to 20 of about 16,230 (221)

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor [PDF]

Frontiers in Pharmacology, 2020
G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein ...
Emiliana Echeverría, Emiliana Echeverría, Maia Cabrera, Maia Cabrera, Valeria Burghi, Valeria Burghi, Máximo Sosa, Máximo Sosa, Sonia Ripoll, Sonia Ripoll, Agustín Yaneff, Agustín Yaneff, Federico Monczor, Federico Monczor, Carlos Davio, Carlos Davio, Carina Shayo, Natalia Fernández, Natalia Fernández   +18 more
doaj   +2 more sources

Transient homologous mu-opioid receptor desensitization in rat locus coeruleus neurons [PDF]

The Journal of Neuroscience, 1991
Opioid agonists hyperpolarize neurons of the locus coeruleus (LC) in the slice preparation. When opioids were applied at concentrations that caused a maximum hyperpolarization, the membrane potential hyperpolarized to a peak (about 30 mV) in the first minute and then declined over a period of 5 min.
G C, Harris, J T, Williams
openaire   +4 more sources

Double Mutation at the Putative Protein Kinase C Phosphorylation Sites Thr151 Plus Thr323 in the Mouse LeukotrieneD4 Receptor Eliminates Homologous Desensitization

Cellular Physiology and Biochemistry, 2013
Background/Aims: Signalling via CysLT1 is involved in activation of volume sensitive K+ channels and homologous desensitization of the LTD4 receptor impairs regulatory volume decrease (RVD). The aim is to illustrate the effect of mutation of putative PKC
Sune T. Jørgensen, Heidi N. Eriksen, Janni Dausell, Thomas Jespersen, Ian H. Lambert, Else K. Hoffmann   +5 more
doaj   +2 more sources

Modeling the Role of Homologous Receptor Desensitization in Cell Gradient Sensing [PDF]

The Journal of Immunology, 2008
Abstract G-protein-coupled chemoattractant receptors signal transiently upon ligand binding to effect cell orientation and motility but then are rapidly desensitized. The importance of desensitization has been unclear, because mutated nondesensitizable receptors mediate efficient chemotaxis.
Francis, Lin, Eugene C, Butcher
openaire   +4 more sources

Homologous β-adrenergic desensitization in isolated rat hepatocytes [PDF]

Biochemical Journal, 1987
Hepatocytes from hypothyroid rats have a marked beta-adrenergic responsiveness. Preincubation of these hepatocytes with isoprenaline induced a time-dependent and concentration-dependent desensitization of the beta-adrenergic responsiveness without altering that to glucagon (homologous desensitization).
J A, García-Sáinz, B, Michel
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Phosphorylation of the Prostacyclin Receptor during Homologous Desensitization [PDF]

Journal of Biological Chemistry, 1998
E.M. Smyth, W. Hong Li, G.A. FitzGerald
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Divergent Mechanisms for Homologous Desensitization of p21 by Insulin and Growth Factors [PDF]

Journal of Biological Chemistry, 1995
Previous work suggested that desensitization of p21ras in response to growth factors such as epidermal growth factor (EGF) results from receptor down-regulation. Here we show that p21ras is desensitized by insulin in 3T3-L1 adipocytes in the continued presence of activated insulin receptors, while loss of epidermal growth factor and platelet-derived ...
Klarlund, Jes K., Cherniack, Andrew D., Czech, Michael P.   +2 more
openaire   +5 more sources

The GnRH receptor and the response of gonadotrope cells to GnRH pulse frequency code. A story of an atypical adaptation of cell function relying on a lack of receptor homologous desensitization.

Folia Histochemica et Cytobiologica, 2010
Brain control of the reproductive system is mediated through hypothalamic gonadotropin-releasing hormone (GnRH) which activates specific receptors (GnRHR) present at the surface of the pituitary gonadotropes to trigger secretion of the two gonadotropins ...
Christian Bleux, Violaine Simon, Jean-NoĂŤl Laverriere, Ghislaine Garrel, Raymond Counis, Solange Magre, JoĂŤlle Cohen-Tannoudji   +6 more
doaj   +4 more sources

Modeling cell gradient sensing and migration in competing chemoattractant fields. [PDF]

PLoS ONE, 2011
Directed cell migration mediates physiological and pathological processes. In particular, immune cell trafficking in tissues is crucial for inducing immune responses and is coordinated by multiple environmental cues such as chemoattractant gradients ...
Dan Wu, Francis Lin
doaj   +1 more source

Long-term incubation with CXCL2, but not with CXCL1, alters the kinetics of TRPV1 receptors in cultured dorsal root ganglia neurons [PDF]

Archives of Biological Sciences, 2017
CXCL1 and CXCL2 are homologous chemokines that can be upregulated in different pathological conditions, affecting among other targets, neuronal ionic channels or receptors.
Deftu Antonia-Teona, Deftu Alexandru-Florian, Ristoiu Violeta   +2 more
doaj   +1 more source