Results 201 to 210 of about 16,230 (221)
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Homologous and heterologous desensitization mediated by vasopressin in smooth muscle cells
Cellular Signalling, 1989Prolonged exposure of A-10 cells to Arginine Vasopressin (AVP) resulted in the following responses: (a) loss of vasopressin receptors from the cell surface (30-40%), (b) increased basal levels of inositol and inositol monophosphate, (c) decreased inositol di- and trisphosphate production and decreased intracellular calcium release in response to a ...
P, Nambi +4 more
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δ Opioid Receptor in Neuronal Cells Undergoes Acute and Homologous Desensitization
Biochemical and Biophysical Research Communications, 1996Using delta opioid receptor as a model system, acute desensitization of neuronal opioid receptor was studied in detail in neuroblastoma x glioma NG108-15 cells and primarily-cultured mouse cortical cells. The opioid desensitization could occur in as short as 3 minutes of agonist treatment and the half-life of the desensitized state was about 90 minutes.
Y, Cai, Y, Zhang, Y, Wu, G, Pei
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Molecular Pharmacology, 1985
Previous work has demonstrated that injection of rats with isoproterenol is rapidly (10 min) followed by the development of a homologous form of desensitization of the beta-agonist-coupled adenylate cyclase in lung membranes. Half the receptor pool becomes sequestered in a light membrane fraction while the other half remains in the plasma membranes but
R H, Strasser +4 more
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Previous work has demonstrated that injection of rats with isoproterenol is rapidly (10 min) followed by the development of a homologous form of desensitization of the beta-agonist-coupled adenylate cyclase in lung membranes. Half the receptor pool becomes sequestered in a light membrane fraction while the other half remains in the plasma membranes but
R H, Strasser +4 more
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Trends in Pharmacological Sciences, 1996
Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitization, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC).
Tsu Tshen Chuang +3 more
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Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitization, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC).
Tsu Tshen Chuang +3 more
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Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons.
Molecular Pharmacology, 1992Exposure of mouse colliculi neurons to selective 5-hydroxytryptamine (5-HT)4 agonists was accompanied by a rapid desensitization of the receptor-stimulated adenylyl cyclase response. Half-maximal desensitization occurred after 2 min. Only exposure of neurons to selective 5-HT4 agonists led to a potent desensitization of the 5-HT4-mediated response ...
H, Ansanay +3 more
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Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.
The Journal of Pharmacology and Experimental Therapeutics, 1992Desensitization of platelet thromboxane (TX)A2/prostaglandin (PG)H2 receptors was induced by incubating platelet-rich plasma with the stable PGH2 analog 11 alpha,9 alpha-(epoxymethano)prosta-5Z,13E-dienoic acid (U46619) (1 microM). Iloprost, a stable prostacyclin analog, was included in the incubation to prevent platelet activation.
A K, Okwu, M E, Ullian, P V, Halushka
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Homologous and Heterologous Acute Desensitization of Vasopressin V1a Receptor in Xenopus Oocytes
Cellular Signalling, 1998The mechanism of short-term desensitisation of the V1a vasopressin receptor, a phospholipase-C beta linked receptor, was investigated in albino Xenopus oocytes. V1a receptors showed rapid agonist-dependent mobilisation of intracellular calcium, as detected by aequorin photon emission.
N, Ancellin, A, Morel
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β-Adrenergic regulation of Sertoli cell adenylyl cyclase: desensitization by homologous hormone
Molecular and Cellular Endocrinology, 1984Incubation of Sertoli cell-enriched cultures with D,L-isoproterenol caused a time- and concentration-dependent, homologous desensitization of isoproterenol-responsive adenyl cyclase, whereas the response to FSH was unaffected. Half-maximal desensitization was achieved within 1 h of preincubation, after which a more gradual loss of response was observed.
Attramadal, H. +3 more
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Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization
Brain Research, 1993The effect of myo-inositol was examined on 5-HT2 receptor mediated facilitation of NMDA depolarization of rat neocortical neurons in vitro. Myo-inositol (1-10 mM) potentiated the 5-HT facilitation, the potentiation increasing linearly with log 5-HT concentration.
S, Rahman, R S, Neuman
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Homologous vs. heterologous desensitization of the adenylate cyclase system in heart cells
European Journal of Pharmacology, 1988Exposure of cultured heart muscle cells to noradrenaline led to a decrease in the effects of isoproterenol and prostaglandin E1 on cAMP formation and contraction velocity. However, heterologous desensitization, as measured by prostaglandin E1 stimulation, only occurred at higher noradrenaline concentrations than homologous desensitization ...
C, Reithmann, K, Werdan
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