Results 211 to 220 of about 16,230 (221)
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Down-Regulation of Prostaglandin E Receptors and Homologous Desensitization of Isolated Adipocytes
Endocrinology, 1983Adipocytes are known to contain prostaglandin E (PGE) binding sites and PGE is known to be antilipolytic. These studies were performed to ascertain whether PGE binding sites in isolated adipocytes can be down-regulated and whether down-regulation (DR) decreases the sensitivity of the fat cell to the antilipolytic effects of PGE2, adenosine, and insulin.
R P, Robertson, S A, Little
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Homologous desensitization of the murine luteinizing hormone receptor expressed in L cells
Molecular and Cellular Endocrinology, 1995Using a clonal cell line that stably expresses the murine luteinizing hormone receptor (LHR 11/6 cells), we studied the molecular mechanisms of agonist-induced desensitization of the luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase.
T, Gudermann +2 more
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European Journal of Pharmacology, 2010
To investigate the susceptibility of the group II metabotropic glutamate receptor mGlu2 to agonist-induced desensitization, the receptor was stably expressed in Chinese hamster ovary (CHO-mGlu2) or C6 glioma cells (C6-mGlu2). Exposure of CHO-mGlu2 cells to the group II mGlu receptor agonist (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (LCCG-1; 10 μM) for
Lennon, SM +6 more
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To investigate the susceptibility of the group II metabotropic glutamate receptor mGlu2 to agonist-induced desensitization, the receptor was stably expressed in Chinese hamster ovary (CHO-mGlu2) or C6 glioma cells (C6-mGlu2). Exposure of CHO-mGlu2 cells to the group II mGlu receptor agonist (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (LCCG-1; 10 μM) for
Lennon, SM +6 more
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The Journal of Pharmacology and Experimental Therapeutics, 1998
The role of drug efficacy in agonist-induced desensitization was studied in C-6 glioma cells transfected with the monkey dopamine D1A (mD1A) receptor. Dopamine pretreatment for 2 hr produced greater than 80% loss of responsiveness in the stimulation of cAMP accumulation that was blocked by the D1 antagonist SCH23390.
M M, Lewis +4 more
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The role of drug efficacy in agonist-induced desensitization was studied in C-6 glioma cells transfected with the monkey dopamine D1A (mD1A) receptor. Dopamine pretreatment for 2 hr produced greater than 80% loss of responsiveness in the stimulation of cAMP accumulation that was blocked by the D1 antagonist SCH23390.
M M, Lewis +4 more
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The Journal of Pharmacology and Experimental Therapeutics, 1999
Acute desensitization of contraction and its relative mechanisms have been studied in smooth muscle cells isolated from guinea pig stomach. Desensitization was induced by pre-exposure of the cells to one of the excitatory neuropeptides linked to the phospholipase C intracellular cascade, i.e., cholecystokinin (CCK), gastrin-releasing peptide, and ...
SEVERI C +7 more
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Acute desensitization of contraction and its relative mechanisms have been studied in smooth muscle cells isolated from guinea pig stomach. Desensitization was induced by pre-exposure of the cells to one of the excitatory neuropeptides linked to the phospholipase C intracellular cascade, i.e., cholecystokinin (CCK), gastrin-releasing peptide, and ...
SEVERI C +7 more
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Homologous desensitization of thromboxane A2 receptor in 1321N1 human astrocytoma cells.
The Journal of Pharmacology and Experimental Therapeutics, 1996The desensitization mechanisms that regulate the response to thromboxane A2 (TXA2) were investigated in 1321N1 human astrocytoma cells. Exposure of the cells to 9,11-epithio-11, 12-methanothromboxane A2 (STA2), a stable TXA2 receptor agonist, at a concentration of 1 microM for 30 to 45 min resulted in about a 50% decrease in subsequent STA2-stimulated ...
K, Sakai +4 more
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Homologous and heterologous adenylate cyclase system desensitization in glial cells.
Functional neurology, 1992In the present research the desensitization of adenylate cyclase system induced by isoproterenol (IPR), a beta-adrenergic agonist, in primary glial cell cultures and the effects of an exposure to 3-isobutyl-1-methylxanthine (IBMX) on the response to a subsequent stimulation with IPR have been investigated.
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Homologous and heterologous desensitization to calcitonin in T47D cells
Acta Endocrinologica, 1989A. KOPPOLD +4 more
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