Frontiers in Molecular Biosciences, 2023 Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt +5 more
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Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3. [PDF]
PLoS ONE, 2015 The lysophosphatidic acid receptors LPA1, LPA2, and LPA3 were individually expressed in C9 cells and their signaling and regulation were studied. Agonist-activation increases intracellular calcium concentration in a concentration-dependent fashion ...
Rocío Alcántara-Hernández +4 more
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Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern. [PDF]
FEBS J, 2010 Schröter J +7 more
europepmc +3 more sources
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
The Journal of Clinical Investigation, 2022 The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized, catecholamine resistance remains largely unexplored.
Joseph M. Valentine +16 more
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eLife, 2021 Gonadotropin-releasing hormone (GnRH) is the primary neuropeptide controlling reproduction in vertebrates. GnRH stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) synthesis via a G-protein-coupled receptor, GnRHR, in the pituitary
Chirine Toufaily +16 more
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Desensitization by Different Strategies of Epidermal Growth Factor Receptor and ErbB4
Journal of Pharmacological Sciences, 2014 Four transmembrane tyrosine kinases constitute the ErbB protein family: epidermal growth factor receptor (EGFR) or ErbB1, ErbB2, ErbB3, and ErbB4. In general, the structure and mechanism of the activation of these members are similar.
Hideyuki Yamamoto +7 more
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Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors [PDF]
, 1995 We constructed chimeras of the rat beta 2 and beta 4 neuronal nicotinic subunits to locate the regions that contribute to differences between the acetylcholine (ACh) dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 receptors ...
Cohen, B. N. +5 more
core +2 more sources
GRKs as Modulators of Neurotransmitter Receptors
Cells, 2020 Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich +1 more
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μ‐Opioid receptor desensitization: homologous or heterologous?
European Journal of Neuroscience, 2012 AbstractThere is considerable controversy over whether μ‐opioid receptor (MOPr) desensitization is homologous or heterologous and over the mechanisms underlying such desensitization. In different cell typesMOPr desensitization has been reported to involve receptor phosphorylation by various kinases, includingG‐protein‐coupled receptor kinases (GRKs ...
Llorente, Javier +6 more
openaire +4 more sources
Molecular basis for heat desensitization of TRPV1 ion channels. [PDF]
, 2019 The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows ...
Kamau, Peter Muiruri +8 more
core +2 more sources