Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
core +3 more sources
Analysis of Structural Determinants of Peptide MS 9a-1 Essential for Potentiating of TRPA1 Channel
Marine Drugs, 2022 The TRPA1 channel is involved in a variety of physiological processes and its activation leads to pain perception and the development of inflammation.
Yulia A. Logashina +6 more
doaj +1 more source
A functional screen provides evidence for a conserved, regulatory, juxtamembrane phosphorylation site in guanylyl cyclase a and B. [PDF]
PLoS ONE, 2012 Kinase homology domain (KHD) phosphorylation is required for activation of guanylyl cyclase (GC)-A and -B. Phosphopeptide mapping identified multiple phosphorylation sites in GC-A and GC-B, but these approaches have difficulty identifying sites in poorly
Andrea R Yoder +7 more
doaj +1 more source
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core +1 more source
Homologous desensitization of metabolotropic glutamate receptors in neuronal cultures
Pharmacological Research, 1990 [No abstract available]
Catania MV +4 more
openaire +5 more sources
The origin and evolution of G protein-coupled receptor kinases. [PDF]
PLoS ONE, 2012 G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling.
Arcady Mushegian +2 more
doaj +1 more source
M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]
, 2017 Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa +2 more
core +1 more source
Combined IMIG and Immune Ig Attenuate Allergic Responses in Beagle Dogs
Journal of Immunology Research, 2020 Background. We previously reported attenuation of serum OVA-specific IgE levels and of lymphocyte-derived IL-4, both nominal markers of allergic immunity, following injection of a combination of homologous (mouse) polyclonal anti-idiotypic immunoglobulin
R. M. Gorczynski +2 more
doaj +1 more source
Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]
, 2000 Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core +1 more source
Heterologous amplification of homologous beta-adrenoceptor desensitization in airway smooth muscle
, 2006 Astma is een wereldwijd voorkomende ziekte, waarvan de prevalentie steeds verder toeneemt. Deze ziekte wordt gekenmerkt door een chronische ontsteking van de luchtwegen, waarbij vele cellen, zoals mestcellen, eosinofielen, T-lymfocyten, neutrofielen, epitheelcellen en luchtweg gladde spiercellen, een belangrijke rol spelen.
Mark Boterman
openaire +2 more sources