Results 31 to 40 of about 264,308 (203)

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

Proceedings of the National Academy of Sciences of the United States of America, 1989
Martin J. Lohse, Robert J. Lefkowitz, M G Caron, Jeffrey Benovic   +3 more
openalex   +3 more sources

Regulation of Corticotropin‐Releasing Factor Receptor Function in Human Y‐79 Retinoblastoma Cells: Rapid and Reversible Homologous Desensitization but Prolonged Recovery [PDF]

Journal of Neurochemistry, 1997
Richard L. Hauger, Frank M. Dautzenberg, Andrea Flaccus, Thomas Liepold, Joachim Spiess   +4 more
openalex   +2 more sources

Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

Frontiers in Molecular Biosciences, 2023
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Ford   +5 more
doaj   +1 more source

Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]

Eur J Neurosci
ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Ciscato M, Chouvaeff M, Mourot A.
europepmc   +2 more sources

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

The Journal of Clinical Investigation, 2022
The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized, catecholamine resistance remains largely unexplored.
Joseph M. Valentine, Maryam Ahmadian, Omer Keinan, Mohammad Abu-Odeh, Peng Zhao, Xin Zhou, Mark P. Keller, Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, Alan R. Saltiel   +16 more
doaj   +1 more source

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3. [PDF]

PLoS ONE, 2015
The lysophosphatidic acid receptors LPA1, LPA2, and LPA3 were individually expressed in C9 cells and their signaling and regulation were studied. Agonist-activation increases intracellular calcium concentration in a concentration-dependent fashion ...
Rocío Alcántara-Hernández, Aurelio Hernández-Méndez, Gisselle A Campos-Martínez, Aldo Meizoso-Huesca, J Adolfo García-Sáinz   +4 more
doaj   +1 more source

Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

eLife, 2021
Gonadotropin-releasing hormone (GnRH) is the primary neuropeptide controlling reproduction in vertebrates. GnRH stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) synthesis via a G-protein-coupled receptor, GnRHR, in the pituitary
Chirine Toufaily, Jérôme Fortin, Carlos AI Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C Hanyaloglu, Terence E Hébert, Tatiana Fiordelisio, Derek Boerboom, Daniel J Bernard   +16 more
doaj   +1 more source

Desensitization by Different Strategies of Epidermal Growth Factor Receptor and ErbB4

Journal of Pharmacological Sciences, 2014
Four transmembrane tyrosine kinases constitute the ErbB protein family: epidermal growth factor receptor (EGFR) or ErbB1, ErbB2, ErbB3, and ErbB4. In general, the structure and mechanism of the activation of these members are similar.
Hideyuki Yamamoto, Sayomi Higa-Nakamine, Nobuhiro Noguchi, Noriko Maeda, Yutaka Kondo, Seikichi Toku, Ichiro Kukita, Kazuhiro Sugahara   +7 more
doaj   +1 more source

GRKs as Modulators of Neurotransmitter Receptors

Cells, 2020
Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich, Vsevolod V. Gurevich   +1 more
doaj   +1 more source

Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling.

Biochim Biophys Acta, 2007
Kelley-Hickie LP, O'Keeffe MB, Reid HM, Kinsella BT.   +3 more
europepmc   +2 more sources