Do β-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder?
Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 Martin C. Michel
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Global trend of food-induced anaphylaxis: Up to date. [PDF]
Pediatr Allergy ImmunolAbstract This review examines the evolving global landscape of food‐induced anaphylaxis (FIA), revealing critical epidemiological shifts that challenge traditional allergen management paradigms. As the leading cause of anaphylaxis worldwide, FIA demonstrates striking geographic, age‐specific, and temporal patterns that reflect broader changes in ...
Leung AS +10 more
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Analysis of Structural Determinants of Peptide MS 9a-1 Essential for Potentiating of TRPA1 Channel
Marine Drugs, 2022 The TRPA1 channel is involved in a variety of physiological processes and its activation leads to pain perception and the development of inflammation.
Yulia A. Logashina +6 more
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A functional screen provides evidence for a conserved, regulatory, juxtamembrane phosphorylation site in guanylyl cyclase a and B. [PDF]
PLoS ONE, 2012 Kinase homology domain (KHD) phosphorylation is required for activation of guanylyl cyclase (GC)-A and -B. Phosphopeptide mapping identified multiple phosphorylation sites in GC-A and GC-B, but these approaches have difficulty identifying sites in poorly
Andrea R Yoder +7 more
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Homologous desensitization of metabolotropic glutamate receptors in neuronal cultures
Pharmacological Research, 1990 [No abstract available]
Catania MV +4 more
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The origin and evolution of G protein-coupled receptor kinases. [PDF]
PLoS ONE, 2012 G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling.
Arcady Mushegian +2 more
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Combined IMIG and Immune Ig Attenuate Allergic Responses in Beagle Dogs
Journal of Immunology Research, 2020 Background. We previously reported attenuation of serum OVA-specific IgE levels and of lymphocyte-derived IL-4, both nominal markers of allergic immunity, following injection of a combination of homologous (mouse) polyclonal anti-idiotypic immunoglobulin
R. M. Gorczynski +2 more
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GPCR Signaling Regulation: The Role of GRKs and Arrestins
Frontiers in Pharmacology, 2019 Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies.
Vsevolod V. Gurevich +1 more
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PLoS ONE, 2019 The nicotinic acetylcholine receptor (nAChR) is an excitatory pentameric ligand-gated ion channel (pLGIC), homologous to the inhibitory γ-aminobutyric acid (GABA) type A receptor targeted by pharmaceuticals and endogenous sedatives.
Steven X Moffett +3 more
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A model for the fast synchronous oscillations of firing rate in rat suprachiasmatic nucleus neurons cultured in a multielectrode array dish. [PDF]
PLoS ONE, 2014 When dispersed and cultured in a multielectrode dish (MED), suprachiasmatic nucleus (SCN) neurons express fast oscillations of firing rate (FOFR; fast relative to the circadian cycle), with burst duration ∼10 min, and interburst interval varying from 20 ...
Andrey R Stepanyuk +2 more
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