Results 41 to 50 of about 16,230 (221)
Agonist-induced internalization and desensitization of the apelin receptor [PDF]
, 2016 Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR) trafficking has an important role in the regulation of receptor signalling pathways and cellular ...
Lolait, Stephen J. +4 more
core +2 more sources
GPCR Signaling Regulation: The Role of GRKs and Arrestins
Frontiers in Pharmacology, 2019 Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies.
Vsevolod V. Gurevich +1 more
doaj +1 more source
Circadian Aqueous Flow Mediated by β-arrestin Induced Homologous Desensitization
Experimental Eye Research, 1997 It was hypothesized that homologous desensitization regulates signal transduction from the beta-adrenergic receptor in the ocular ciliary epithelium to affect the circadian rhythm of aqueous humor secretion. beta-arrestin-1 was cloned from the rabbit ciliary epithelium, and the full length cDNA used as a probe for Northern blot analysis to examine the ...
X L, Wan, J, Sears, S, Chen, M, Sears
openaire +2 more sources
PLoS ONE, 2019 The nicotinic acetylcholine receptor (nAChR) is an excitatory pentameric ligand-gated ion channel (pLGIC), homologous to the inhibitory γ-aminobutyric acid (GABA) type A receptor targeted by pharmaceuticals and endogenous sedatives.
Steven X Moffett +3 more
doaj +1 more source
A model for the fast synchronous oscillations of firing rate in rat suprachiasmatic nucleus neurons cultured in a multielectrode array dish. [PDF]
PLoS ONE, 2014 When dispersed and cultured in a multielectrode dish (MED), suprachiasmatic nucleus (SCN) neurons express fast oscillations of firing rate (FOFR; fast relative to the circadian cycle), with burst duration ∼10 min, and interburst interval varying from 20 ...
Andrey R Stepanyuk +2 more
doaj +1 more source
Journal of Biological Chemistry, 1992 Three main pathways have been implicated in desensitization of receptors that stimulate adenylylcyclase (AC): cAMP-mediated phosphorylation; cAMP-independent phosphorylation, and receptor internalization. Cell lines derived from the murine Ltk- cell were found useful in exploring the contribution of cAMP-dependent phosphorylation in V2 vasopressin ...
M, Birnbaumer +3 more
openaire +2 more sources
Structural and functional characterization of an otopetrin family proton channel
eLife, 2019 The otopetrin (OTOP) proteins were recently characterized as proton channels. Here we present the cryo-EM structure of OTOP3 from Xenopus tropicalis (XtOTOP3) along with functional characterization of the channel.
Qingfeng Chen +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2020 Acid-sensing ion channels (ASICs) act as pH sensors in neurons. ASICs contribute to pain sensation, learning, fear behavior and to neuronal death after ischemic stroke.
Olivier Bignucolo +5 more
doaj +1 more source
Adrenergic receptors. Models for regulation of signal transduction processes. [PDF]
, 1990 Adrenergic receptors are prototypic models for the study of the relations between structure and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene.
Caron, MG +3 more
core +1 more source
Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.
PLoS ONE, 2017 Elucidation of the structural basis of pharmacological differences for highly homologous α7 and α9 nicotinic acetylcholine receptors (nAChRs) may shed light on their involvement in different physiological functions and diseases.
Irina Shelukhina +7 more
doaj +1 more source