Results 51 to 60 of about 16,230 (221)

Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]

, 2001
To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P., Chavkin, Charles, Gurevich, Vsevolod V., Kovoor, Abraham, Lowe, Janet   +4 more
core  

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Carbachol-Induced Secretion and Homologous Desensitization in Rat Basophilic Leukemia (RBL-2H3) Cells Transfected With Human m2 Muscarinic Acetylcholine Receptors

Journal of Pharmacological Sciences, 2004
Carbachol (CCh) caused a dose-dependent release of β-hexosaminidase and an increase in the production of inositol 1,4,5-trisphosphate (IP3) in RBL-2H3 cells transfected with m2 mAChR cDNA (RBL-m2 cells).
Kazuhiko Oishi, Akihiro Sakurai, Noriyasu Seki, Tomokazu Yoshizumi, Masaatsu K. Uchida   +4 more
doaj   +1 more source

Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits [PDF]

, 2015
The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action.
Allgaier, Alvestad, Anders, Anders, Boyce-Rustay, Chandrasekar, Chu, Dingledine, Donard S. Dwyer, Dopico, Dwyer, Erreger, Gass, Gonzales, Göthert, Hoffman, Holmes, Hong Ren, Honse, Izumi, Karakas, Kash, Kash, Kash, Koob, Krishnan-Sarin, Krupitsky, Krystal, Kuner, Lima-Landman, Lovinger, Low, Low, Masood, Mihic, Moykkynen, Nagy, Peoples, Peoples, Peoples, Popp, Ren, Ren, Ren, Ren, Ren, Ren, Robert W. Peoples, Ronald, Salous, Smothers, Smothers, Smothers, Sobolevsky, Sobolevsky, Vengeliene, Vengeliene, Wang, Weiss, Wick, Wills, Woodward, Woodward, Wright, Xu, Xu, Yamakura, Yuan, Yulin Zhao   +68 more
core   +2 more sources

Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus

Insect Science, EarlyView.
Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami, Ian Orchard, Angela B. Lange   +2 more
wiley   +1 more source

Equilibrium Properties of Mouse-Torpedo Acetylcholine Receptor Hybrids Expressed in Xenopus Oocytes [PDF]

, 1987
This study used messenger RNA encoding each subunit (α, β, γ and δ) of the nicotinic acetylcholine (ACh) receptor from mouse BC3H-1 cells and from Torpedo electric organ.
Davidson, Norman, Lester, Henry A., Mayne, Katharine Mixter, Yoshii, Kiyonori, Yu, Lei   +4 more
core   +3 more sources

The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation

Andrology, EarlyView.
Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández, Ferran Garriga, Adeel Ahmad, Lorena Padilla, Carolina Maside, Sergi Bonet, Isabel Barranco, Jordi Roca, Luis Miguel Pastor, Marc Yeste   +9 more
wiley   +1 more source

Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors—A Consequence of Evolutionary Pressure?

Advances in Virology, 2012
Several herpes- and poxviruses have captured chemokine receptors from their hosts and modified these to their own benefit. The human and viral chemokine receptors belong to class A 7 transmembrane (TM) receptors which are characterized by several ...
Ann-Sofie Mølleskov Jensen, Alexander Hovard Sparre-Ulrich, Nicholas Davis-Poynter, Mette Marie Rosenkilde   +3 more
doaj   +1 more source

New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations

Cells, 2020
Insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II) play a crucial factor in the growth, differentiation and survival of cells in health and disease.
Joseph A.M.J.L. Janssen
doaj   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source