Results 51 to 60 of about 264,308 (203)
Structural and functional characterization of an otopetrin family proton channel
eLife, 2019 The otopetrin (OTOP) proteins were recently characterized as proton channels. Here we present the cryo-EM structure of OTOP3 from Xenopus tropicalis (XtOTOP3) along with functional characterization of the channel.
Qingfeng Chen +4 more
doaj +1 more source
Protein kinase C potentiates isoproterenol‐mediated cyclic AMP production without modifying the homologous desensitization process in J774 cells [PDF]
European Journal of Biochemistry, 1987 Anne‐Marie Chambaut‐Guérin +1 more
openalex +2 more sources
Frontiers in Molecular Biosciences, 2020 Acid-sensing ion channels (ASICs) act as pH sensors in neurons. ASICs contribute to pain sensation, learning, fear behavior and to neuronal death after ischemic stroke.
Olivier Bignucolo +5 more
doaj +1 more source
Homologous desensitization of signalling by the beta (β) isoform of the human thromboxane A2 receptor [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006 Thromboxane (TX) A(2) is a potent stimulator of platelet activation/aggregation and smooth muscle contraction and contributes to a variety of pathologies within the vasculature. In this study, we investigated the mechanism whereby the cellular responses to TXA(2) mediated through the TPbeta isoform of the human TXA(2) receptor (TP) are dynamically ...
Kelley-Hickie, Leanne P. +1 more
openaire +4 more sources
Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.
PLoS ONE, 2017 Elucidation of the structural basis of pharmacological differences for highly homologous α7 and α9 nicotinic acetylcholine receptors (nAChRs) may shed light on their involvement in different physiological functions and diseases.
Irina Shelukhina +7 more
doaj +1 more source
Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2004 Carbachol (CCh) caused a dose-dependent release of β-hexosaminidase and an increase in the production of inositol 1,4,5-trisphosphate (IP3) in RBL-2H3 cells transfected with m2 mAChR cDNA (RBL-m2 cells).
Kazuhiko Oishi +4 more
doaj +1 more source
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Andrology, EarlyView.Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández +9 more
wiley +1 more source
Advances in Virology, 2012 Several herpes- and poxviruses have captured chemokine receptors from their hosts and modified these to their own benefit. The human and viral chemokine receptors belong to class A 7 transmembrane (TM) receptors which are characterized by several ...
Ann-Sofie Mølleskov Jensen +3 more
doaj +1 more source