Results 61 to 70 of about 264,308 (203)

New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations

Cells, 2020
Insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II) play a crucial factor in the growth, differentiation and survival of cells in health and disease.
Joseph A.M.J.L. Janssen
doaj   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Do horizontal saccadic eye movements increase interhemispheric coherence? Investigation of a hypothesized neural mechanism underlying EMDR

Frontiers in Psychiatry, 2011
Series of horizontal saccadic eye movements (EMs) are known to improve episodic memory retrieval in healthy adults and to facilitate the processing of traumatic memories in eye-movement desensitization and reprocessing (EMDR) therapy.
Zoe eSamara, Zoe eSamara, Bernet M. Elzinga, Bernet M. Elzinga, Heleen A Slagter, Sander eNieuwenhuis, Sander eNieuwenhuis   +6 more
doaj   +1 more source

Circadian Aqueous Flow Mediated by β-arrestin Induced Homologous Desensitization

Experimental Eye Research, 1997
It was hypothesized that homologous desensitization regulates signal transduction from the beta-adrenergic receptor in the ocular ciliary epithelium to affect the circadian rhythm of aqueous humor secretion. beta-arrestin-1 was cloned from the rabbit ciliary epithelium, and the full length cDNA used as a probe for Northern blot analysis to examine the ...
X L, Wan, J, Sears, S, Chen, M, Sears
openaire   +2 more sources

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Calcium signaling in crops

New Phytologist, EarlyView.
Summary Calcium (Ca2+) signaling is integral to nearly all aspects of plant biology, including development and responses to biotic and abiotic stresses. It operates through two main layers: the generation of Ca2+ signals and their decoding by Ca2+‐binding proteins, which act early in diverse signaling pathways. The system exhibits remarkable robustness
Chunxia Zhang, Yang Song, Jörg Kudla
wiley   +1 more source

Wheat TaSPL13‐2B Improves Floret Fertility and Enhances Grain Number per Spikelet Through Jasmonic Acid Signalling Pathway

Plant Biotechnology Journal, EarlyView.
ABSTRACT Floret fertility is a key determinant of grain number per spike and an important factor in cereal crop yield. However, the mechanisms by which phytohormone signalling and transcription factors coordinately regulate floret fertility and spikelet development are not well understood, especially in wheat.
Li Li, Fu Shi, Yaqiong Wang, Yanbin Guan, Ya'nan Wu, Ling Chen, Junli Chang, Mingjie Chen, Jun Xiao, Guangxiao Yang, Yuesheng Wang, Guangyuan He, Yin Li   +12 more
wiley   +1 more source

Altered D1 dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates

Neurobiology of Disease, 2007
Dyskinesias represent a debilitating complication of levodopa therapy for Parkinson's disease (PD). While we recently demonstrated that levodopa-induced dyskinesia results from increased dopamine D1 receptor-mediated transmission, we also questioned the ...
Céline Guigoni, Evelyne Doudnikoff, Qin Li, Bertrand Bloch, Erwan Bezard   +4 more
doaj   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

A Cost-Utility Analysis of SQ® Tree SLIT-Tablet versus Placebo in the Treatment of Birch Pollen Allergic Rhinitis from a Swedish Societal Perspective

ClinicoEconomics and Outcomes Research, 2023
Richard F Pollock,1 Andreas K Slættanes,2 Henrik Brandi,2 Tobias Sydendal Grand2 1Covalence Research Ltd, Harpenden, UK; 2ALK-Abelló A/S, Hørsholm, DenmarkCorrespondence: Andreas K Slættanes, ALK-Abelló A/S, Bøge Allé 1, Hørsholm, DK-2970, Denmark, Tel ...
Pollock RF, Slættanes AK, Brandi H, Grand TS   +3 more
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