Results 81 to 90 of about 264,308 (203)

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, Volume 116, Issue 12, Page 3250-3265, December 2025.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Homologous desensitization of the human guanylate cyclase C receptor

European Journal of Biochemistry, 2000
Guanylate Cyclase C (GCC) serves as a receptor for the endogenous ligands, guanylin and uroguanylin, as well as the family of bacterial heat‐stable enterotoxins (ST), which are one of the major causes of diarrhoea the world over. We had earlier provided evidence that GCC, present in the human colonic T84 cell line, is desensitized on prolonged exposure
Bakre, Manjiri M, Ghanekar, Yashoda, Visweswariah, Sandhya S   +2 more
openaire   +3 more sources

XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Elevated spliced form of X‐box–binding protein 1 (XBP1) correlates with unfavorable responses to endocrine therapy plus CDK4/6 inhibitors in HR+/HER2− advanced breast cancer. XBP1s facilitates cell proliferation and G1/S transition by transcriptionally activating SND1, thereby activating the E2F1 pathway.
Yuting Sang, Shiyang Liu, Xujie Zhou, Weiru Chi, Min Xiong, Ming Chen, Hengyu Ren, Douwaner Liu, Liyi Zhang, Jingyan Xue, Yayun Chi, Jiong Wu   +11 more
wiley   +1 more source

How GPCRs Engage GPCR Kinases in the First Step of Homologous Desensitization

, 2021
J. Tesmer, Qiuyan Chen, Manolo Plasencia, Zhuang Li, Leifu Chang, P. Andrews   +5 more
semanticscholar   +1 more source

Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and β-Arrestin 2 during Homologous Desensitization of the Substance P Receptor [PDF]

, 1999
Larry S. Barak, Kengo Warabi, Feng Xiao, Marc G. Caron, Madan M. Kwatra   +4 more
openalex   +1 more source

Homologous desensitization of β-adrenergic receptors in lymphoma cells is not altered by the inactivation of Ni (Gi), the inhibitory guanine nucleotide regulatory protein [PDF]

, 1986
R B Clark, T J Goka, M A Proll, Jacqueline Friedman   +3 more
openalex   +1 more source

Homologous and heterologous desensitization of histamine H₁‐and ATP‐receptors in the smooth muscle cell line, DDT₁MF‐2: the role of protein kinase C [PDF]

, 1993
John M. Dickenson, Stephen J. Hill
openalex   +1 more source

Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1. [PDF]

, 1996
K Karmann, Min Wang, William C. Fanslow, Jordan S. Pober   +3 more
openalex   +1 more source

Protein kinase C involvement in the homologous desensitization of opioid delta receptor in Xenopus oocytes

, 1995
Hiroshi Ueda, Takeaki Miyamae, Nobuyuki Fukushima, Yoshimi Misu   +3 more
openalex   +1 more source

Blockade of heterologous desensitization of prostate adenylate cyclase without blockade of homologous down regulation of receptors or loss of GTP regulation of agonist binding.

, 1983
Sumio Shima, K Komoriyama, Masanao Hirai, Hiroshi Kouyama   +3 more
openalex   +1 more source