Results 11 to 20 of about 74,508 (147)

The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing

Frontiers in Cell and Developmental Biology, 2023
Meiosis involves deep changes in the spatial organisation and interactions of chromosomes enabling the two primary functions of this process: increasing genetic diversity and reducing ploidy level.
Mireia Solé, Álvaro Pascual, Ester Anton, Joan Blanco, Zaida Sarrate   +4 more
doaj   +1 more source

The synaptonemal complex protein Zip1 promotes bi-orientation of centromeres at meiosis I. [PDF]

PLoS Genetics, 2009
In meiosis I, homologous chromosomes become paired and then separate from one another to opposite poles of the spindle. In humans, errors in this process are a leading cause of birth defects, mental retardation, and infertility.
Mara N Gladstone, David Obeso, Hoa Chuong, Dean S Dawson   +3 more
doaj   +1 more source

Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.

PLoS ONE, 2012
Although somatic homologous pairing is common in Drosophila it is not generally observed in mammalian cells. However, a number of regions have recently been shown to come into close proximity with their homologous allele, and it has been proposed that ...
Christel Krueger, Michelle R King, Felix Krueger, Miguel R Branco, Cameron S Osborne, Kathy K Niakan, Michael J Higgins, Wolf Reik   +7 more
doaj   +1 more source

Characterization of meiotic chromosome behavior in the autopolyploid Saccharum spontaneum reveals preferential chromosome pairing without distinct DNA sequence variation

Crop Journal, 2023
Autopolyploidy and allopolyploidy may represent an evolutionary advantage and are more common in plants than assumed. However, less attention has been paid to autopolyploidy than to allopolyploidy, and its evolutionary consequences are largely unclear ...
Xin Zhang, Zhuang Meng, Jinlei Han, Haris Khurshid, Ayman Esh, Robert Hasterok, Kai Wang   +6 more
doaj   +1 more source

A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]

, 2015
Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco, DE ROOIJ, DIRK GIJSBERT, Di Cecca, Stefano, DI GIACOMO, Monica, DI SIENA, Sara, Faieta, Monica, Luchetti, Andrea, Murdocca, Michela, Pellegrini, Manuela, Rossi, Pellegrino   +9 more
core   +3 more sources

Meiotic chromosome dynamics and double strand break formation in reptiles

Frontiers in Cell and Developmental Biology, 2022
During meiotic prophase I, tightly regulated processes take place, from pairing and synapsis of homologous chromosomes to recombination, which are essential for the generation of genetically variable haploid gametes.
Laia Marín-Gual, Laia Marín-Gual, Laura González-Rodelas, Laura González-Rodelas, Maria M. Garcias, Maria M. Garcias, Lukáš Kratochvíl, Nicole Valenzuela, Arthur Georges, Paul D. Waters, Aurora Ruiz-Herrera, Aurora Ruiz-Herrera   +11 more
doaj   +1 more source

Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]

, 2015
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Alexandra-Styliani Kalantzi, Bergerat, Bishop, Brown, Brunger, Bugreev, Byung-Ha Oh, Case, Chan, Chen, Chi, Cho, Christopher P. Toseland, Cloud, de Massy, De Vlaminck, de Vries, Emsley, Enomoto, Ferrari, Garcia, Haruta, Hayase, Ho-Chul Shin, Holm, Hyun-Ah Kang, Hyun-Min Kim, Keeney, Keeney, Kokabu, Kuwabara, Lange, Leu, Lu, Lu, Lu, Matteo Dal Peraro, Moktan, Morrison, Neale, Okorokov, Otwinowski, Pettersen, Petukhova, Petukhova, Pezza, Pezza, Phillips, Ploquin, Qiao, Rabitsch, Roeder, Rothenberg, Say, Schwacha, Sheridan, Sheridan, Soding, Stephan Gruber, Terwilliger, Tsai, Tsubouchi, Tsubouchi, Uanschou, van der Heijden, Wright, Zhao   +66 more
core   +3 more sources

HO Endonuclease-Initiated Recombination in Yeast Meiosis Fails To Promote Homologous Centromere Pairing and Is Not Constrained To Utilize the Dmc1 Recombinase

G3: Genes, Genomes, Genetics, 2018
Crossover recombination during meiosis is accompanied by a dramatic chromosome reorganization. In Saccharomyces cerevisiae, the onset of meiotic recombination by the Spo11 transesterase leads to stable pairwise associations between previously ...
Lina Yisehak, Amy J. MacQueen
doaj   +1 more source

Pushing the (nuclear) envelope into meiosis. [PDF]

, 2013
A recent study shows that a short isoform of a mammalian nuclear lamin is important for homologous chromosome interactions during meiotic prophase in ...
Dernburg, Abby F
core   +1 more source

Finding the Correct Partner: The Meiotic Courtship

Scientifica, 2012
Homologous chromosomes are usually separated at the entrance of meiosis; how they become paired is one of the outstanding mysteries of the meiotic process.
Tomás Naranjo
doaj   +1 more source