Results 11 to 20 of about 2,294,281 (319)
Homologous pairing preceding SPO11-mediated double-strand breaks in mice. [PDF]
Dev Cell, 2013 SUMMARY How homologous chromosomes (homologs) find their partner, pair and recombine during meiosis constitutes the central phenomenon in eukaryotic genetics.
Boateng KA +4 more
europepmc +2 more sources
Developmental Cell, 2019 Summary Homologous chromosomes colocalize to regulate gene expression in processes including genomic imprinting, X-inactivation, and transvection. In Drosophila, homologous chromosomes pair throughout development, promoting transvection.
Rebecca Rodriguez Viales +2 more
exaly +2 more sources
Role of chromosome ends in meiotic stability, recombination and wheat evolution in the context of breeding [PDF]
BMC Plant BiologyWheat is one of the most important crops worldwide, and understanding its genome organisation is crucial for geneticists and breeders. In this study, we examined the dynamic roles of telomeric and subtelomeric regions in wheat, focusing on their ...
A. Gálvez-Galván +2 more
doaj +2 more sources
Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex
Cell Reports, 2016 The UAF1-USP1 complex deubiquitinates FANCD2 during execution of the Fanconi anemia DNA damage response pathway. As such, UAF1 depletion results in persistent FANCD2 ubiquitination and DNA damage hypersensitivity.
Fengshan Liang +9 more
doaj +2 more sources
RAD51 D-loop structures reveal the mechanism of eukaryotic RAD51-mediated strand exchange [PDF]
Nature CommunicationsStrand exchange is a key step in homologous recombination, enabling template-based repair of DNA double-strand breaks. Eukaryotic RAD51 forms an ATP-dependent helical presynaptic filament on single-stranded DNA (ssDNA), which then searches for homologous
Shih-Chi Luo +6 more
doaj +2 more sources
Electrostatic braiding and homologous pairing of DNA double helices. [PDF]
Biophys J, 2011 Cortini R +3 more
europepmc +2 more sources
Homologous pairing and the role of pairing centers in meiosis [PDF]
Journal of Cell Science, 2011 Homologous pairing establishes the foundation for accurate reductional segregation during meiosis I in sexual organisms. This Commentary summarizes recent progress in our understanding of homologous pairing in meiosis, and will focus on the characteristics and mechanisms of specialized chromosome sites, called pairing centers (PCs), in Caenorhabditis ...
J. Tsai, B. McKee
semanticscholar +3 more sources
OsDMC1 Is Not Required for Homologous Pairing in Rice Meiosis1[OPEN] [PDF]
Plant Physiology, 2016 Meiotic homologous recombination is pivotal to sexual reproduction. DMC1, a conserved recombinase, is involved in directing single-end invasion between interhomologs during meiotic recombination. In this study, we identified OsDMC1A and OsDMC1B, two closely related proteins in rice (Oryza sativa) with high sequence similarity to DMC1 proteins from ...
Hongjun Wang +7 more
semanticscholar +3 more sources
Mediators of homologous DNA pairing. [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 Homologous DNA pairing and strand exchange are at the core of homologous recombination. These reactions are promoted by a DNA-strand-exchange protein assembled into a nucleoprotein filament comprising the DNA-pairing protein, ATP, and single-stranded DNA.
A. Zelensky, R. Kanaar, C. Wyman
semanticscholar +4 more sources