Results 11 to 20 of about 789,870 (314)
Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management
Clinics, 2018 Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio +3 more
semanticscholar +3 more sources
Pan-cancer landscape of homologous recombination deficiency
Nature Communications, 2020 Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD ...
Luan Nguyen +3 more
semanticscholar +2 more sources
Homologous Recombination: To Fork and Beyond [PDF]
Genes, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
F. Prado
semanticscholar +3 more sources
Homologous Recombination Assay
BIO-PROTOCOL, 2013 Repair of double strand break by homologous recombination was examined using U2OS cells or RG37 cells harbouring specific substrate developed by Puget et al. (2005) and Dumay et al. (2006), respectively, to measure the repair of DNA double strand breaks by homologous recombination. The substrate is composed of two inactive copies of the GFP gene.
Yvan Canitrot, Didier Trouche
openaire +3 more sources
Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations [PDF]
npj Precision OncologyThis study examined the relationship between homologous recombination deficiency (HRD) and variations in non-BRCA1/2 homologous recombination repair (HRR) genes.
Yue Li +3 more
doaj +2 more sources
Assessing the association between homologous recombination deficiency scores and treatment response in localized and metastatic prostate cancer [PDF]
The Journal of Pathology: Clinical ResearchThe aim of this study was to evaluate the predictive value of homologous recombination deficiency scores for therapeutic efficacy in prostate cancer across various disease stages under different regimens.
Qiyu Zhu +11 more
doaj +2 more sources
Homologous recombination risk in baculovirus expression vector system
Virus Research, 2022 The baculovirus expression vector system (BEVS) is widely used for producing recombinant proteins. To achieve high expression level of recombinant proteins, baculoviral elements, such as enhancers, promoters, signal peptide coding sequences and 3′-UTR ...
Jianan Huang, Huanlei Liu, Xiaodong Xu
doaj +1 more source
Multi-scale characterisation of homologous recombination deficiency in breast cancer
Genome Medicine, 2023 Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson +3 more
doaj +1 more source
Genome Biology, 2022 Background The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals.
Shenli Yuan +7 more
doaj +1 more source
eLife, 2022 Recombination is essential to microbial evolution, and is involved in the spread of antibiotic resistance, antigenic variation, and adaptation to the host niche.
Asher Preska Steinberg +2 more
doaj +1 more source