Results 11 to 20 of about 218,555 (316)

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency [PDF]

Clinical and Translational Radiation Oncology
Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect.
Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers   +4 more
doaj   +2 more sources

Using single loxP sites to enhance homologous recombination: ts mutants in Sec1 of Dictyostelium discoideum. [PDF]

PLoS ONE, 2007
Dictyostelium discoideum amoebae are haploid and, as they share many features with animal cells, should be an ideal creature for studying basic processes such as cell locomotion.
Mark S Bretscher, Margaret Clotworthy
doaj   +1 more source

Homologous recombination and its regulation [PDF]

Nucleic Acids Research, 2012
Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on
Mário Špírek, Lumir Krejci, Xiaolan Zhao, Veronika Altmannova   +3 more
openaire   +3 more sources

Structural basis of homologous recombination [PDF]

Cellular and Molecular Life Sciences, 2019
AbstractHomologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks (DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein filament on ssDNA, pairs with homologous DNA as a template to repair the damaged site.
Thomas J. McCorvie, Yueru Sun, Luke A. Yates, Xiaodong Zhang   +3 more
openaire   +3 more sources

Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management

Clinics, 2018
Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio, Rodrigo Nogueira Fogace, Vanessa Costa Miranda, Maria del Pilar Estevez Diz   +3 more
doaj   +1 more source

Intermolecular Homologous Recombination in Plants [PDF]

Molecular and Cellular Biology, 1990
To study DNA topological requirements for homologous recombination in plants, we have constructed pairs of plasmids that contain nonoverlapping deletions in the neomycin phosphotransferase gene [APH(3')II], which, when intact, confers kanamycin resistance to plant cells.
M Baur, Jerzy Dr. Paszkowski, I Potrykus
openaire   +3 more sources

Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery

Biomolecules, 2012
Homologous recombination is a universal mechanism that allows DNA repair and ensures the efficiency of DNA replication. The substrate initiating the process of homologous recombination is a single-stranded DNA that promotes a strand exchange reaction ...
Audrey Costes, Sarah A. E. Lambert
doaj   +1 more source

Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51

Nature Communications, 2022
Sister chromatid exchanges (SCEs) are considered to be products of homologous recombination repair. The authors show that SCEs can arise independently of homologous recombination due to processing of replication intermediates during mitosis.
Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K. de Kanter, Yannick P. Kok, Marieke Everts, H. Rudolf de Boer, Anastasia Audrey, Femke J. Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana C. J. Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M. Lansdorp, Marcel A. T. M. van Vugt   +18 more
doaj   +1 more source

Dependence of frequency of homologous recombination on the homology length. [PDF]

Genetics, 1995
Abstract The frequency of homologous recombination is believed to be a linear function of the length (N bp) of homology between DNAs. Here, the N intercept is believed to be determined by a threshold length below which some physical constraint is effective.
Ichizo Kobayashi, Youhei Fujitani, Kimiko Yamamoto   +2 more
openaire   +4 more sources

High fidelity of RecA-catalyzed recombination: a watchdog of genetic diversity [PDF]

Nucleic Acids Research, 2006, Vol. 34, No. 18 5021-5031, 2010
Homologous recombination plays a key role in generating genetic diversity, while maintaining protein functionality. The mechanisms by which RecA enables a single-stranded segment of DNA to recognize a homologous tract within a whole genome are poorly understood.
arxiv   +1 more source