Results 11 to 20 of about 345,396 (332)

Homologous Recombination: To Fork and Beyond [PDF]

Genes, 2018
Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair for later. This process of lesion bypass during DNA damage tolerance can lead to the accumulation of
Prado Velasco, José Félix
openaire   +7 more sources

Homologous recombination in procaryotes. [PDF]

Microbiological Reviews, 1988
Gerald R. Smith
  +7 more sources

BRCA2 and homologous recombination [PDF]

Breast Cancer Research, 2001
Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks.
Brian J. Orelli, Douglas K. Bishop
openaire   +3 more sources

The Regulation of Homologous Recombination by Helicases [PDF]

Genes, 2020
Homologous recombination is essential for DNA repair, replication and the exchange of genetic material between parental chromosomes during meiosis. The stages of recombination involve complex reorganization of DNA structures, and the successful completion of these steps is dependent on the activities of multiple helicase enzymes.
Eric Huselid, Samuel F. Bunting
openaire   +2 more sources

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
A Chavez, A De Muyt, A Hochwagen, A Hochwagen, A Irmisch, A McAleenan, A Schwacha, A Sourirajan, A Svetlanov, AC Chan, AJ Wood, AL Marston, Alex D. Herbert, Alice Copsey, Andreas Hochwagen, Andrew Chi-ho Chan, B Rockmill, BH Lee, C Buhler, C Tapia-Alveal, DM Sheedy, E Ampatzidou, EA Andrews, EA Outwin, ER Hoffmann, Eva Hoffmann, F Osman, FZ Watts, G De Piccoli, G Vader, GA Cromie, GR Smith, GV Borner, H Murakami, Hannah G. Blitzblau, HB Lindroos, HG Blitzblau, HG Blitzblau, HG Yu, HG Yu, I Lilienthal, J Gregan, J Matos, J Matos, J Palecek, J Pan, J Torres-Rosell, J Zalevsky, JA Carballo, JA Downs, JK Holloway, JM Murray, JR Mullen, JR Mullen, JS Bickel, K Nishimura, K Zakharyevich, K Zakharyevich, KA Henderson, KP Kim, KP Kohl, KT Nishant, L Jessop, L Jessop, L Newnham, L Wu, L Xu, LE Berchowitz, LE Hang, LJ Gaskell, Louise Newnham, M Bermudez-Lopez, M Xaver, MA Roy, Michael Lichten, MJ Neale, MN Boddy, MS McMahill, N Hunter, N Hunter, N Wu, Neil Hunter, NK Kolas, O Yildiz, P Jordan, Philip W. Jordan, PR Potts, PR Potts, Prakash Arumugam, RK Clyne, S Agarwal, S Chu, S Farmer, S Gray, S Panizza, S Pebernard, S Wehrkamp-Richter, SB Buonomo, SD Oh, SD Oh, Shangming Tang, SL Andersen, Sonya Newcombe, Stephen Gray, T de los Santos, T Snowden, T Wechsler, TM Carlile, TS Kitajima, V Kaliraman, WM Fricke, X Zhao, Y Blat, YH Chen, YH Chen, Zhaobo Li   +115 more
core   +6 more sources

Homologous Recombination: Down to the Wire [PDF]

Current Biology, 2004
Exchange of strands between homologous DNA molecules is catalyzed by evolutionarily conserved recombinases. These proteins can occur in different quaternary arrangements: rings or helical filaments. Recent results reveal that recombinase function follows from the filamentous form.
Roland Kanaar, Claire Wyman
openaire   +3 more sources

Homologous recombination and its regulation [PDF]

Nucleic Acids Research, 2012
Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on
Mário Špírek, Lumir Krejci, Xiaolan Zhao, Veronika Altmannova   +3 more
openaire   +3 more sources

Double-strand break repair and homologous recombination in Schizosaccharomyces pombe [PDF]

, 2006
In recent years our understanding of double strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased ...
Ahmad, Ahmad, Ahn, Ahnesorg, Akamatsu, Assenmacher, Baumann, Boddy, Boddy, Bonatto, Bransteitter, Buck, Callebaut, Caspari, Catlett, Cervantes, Chahwan, Cheok, Connelly, Cooper, Doe, Doe, Doe, Doe, Dudasova, Farah, Farah, Ferreira, Ferreira, Fukushima, Gaillard, Goedecke, Goodwin, Grishchuk, Haber, Hartsuiker, Hefferin, Jang, Jung, Khasanov, Khasanov, Kibe, Kim, Kim, Krogh, Lambert, Laursen, Macris, Maftahi, Maftahi, Manolis, Marchetti, Martin, McGlynn, Moore, Morishita, Muris, Muris, Muris, Murray, Nakada, Nakamura, Oakley, Ono, Osman, Osman, Osman, Ostermann, Paques, Parker, Prudden, Sauvageau, Schmidt, Segurado, Shinohara, Smith, Steiner, Stewart, Sung, Suto, Szankasi, Szostak, Tarsounas, Tavassoli, Thacker, Tomita, Tomita, Tsutsui, Tsutsui, Ueno, van den Bosch, van den Bosch, Virgin, Virgin, Wang, Weterings, Whitby, Whitby, Wilson, Win, Win, You, Young   +102 more
core   +2 more sources

Structural basis of homologous recombination [PDF]

Cellular and Molecular Life Sciences, 2019
AbstractHomologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks (DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein filament on ssDNA, pairs with homologous DNA as a template to repair the damaged site.
Thomas J. McCorvie, Yueru Sun, Luke A. Yates, Xiaodong Zhang   +3 more
openaire   +3 more sources

PALB2 self-interaction controls homologous recombination. [PDF]

, 2012
PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination.
Buisson, Rémi, Masson, Jean-Yves
core   +1 more source