Results 11 to 20 of about 773,827 (377)

A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors

Nature Cancer, 2021
DNA polymerase theta (POLθ or POLQ) is synthetic lethal with homologous recombination (HR) deficiency and is thus a candidate target for HR-deficient cancers.
Jia Zhou, C. Gelot, Constantia Pantelidou, Adam W. Li, Hatice Yücel, R. Davis, A. Färkkilä, B. Kochupurakkal, Aleem Syed, G. Shapiro, J. Tainer, B. Blagg, Raphael Ceccaldi, A. D’Andrea   +13 more
semanticscholar   +1 more source

Homologous Recombination Deficiencies and Hereditary Tumors

International Journal of Molecular Sciences, 2021
Homologous recombination (HR) is a vital process for repairing DNA double-strand breaks. Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1(NBN), PALB2, RAD51C, and RAD51D, lead to ...
H. Yamamoto, Akira Hirasawa
semanticscholar   +1 more source

Homologous recombination deficiency: cancer predispositions and treatment implications.

The Oncologist, 2021
Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR genes are established cancer susceptibility genes with clinically actionable pathogenic variants (PVs).
M. Toh, J. Ngeow
semanticscholar   +1 more source

Multi-scale characterisation of homologous recombination deficiency in breast cancer

Genome Medicine, 2023
Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson, Shi Pan, Jasmin Fisher, Maria Secrier   +3 more
doaj   +1 more source

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

Genome Biology, 2022
Background The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals.
Shenli Yuan, Tao Huang, Ziyou Bao, Shiyu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, Zi-Jiang Chen   +7 more
doaj   +1 more source

Core genes can have higher recombination rates than accessory genes within global microbial populations

eLife, 2022
Recombination is essential to microbial evolution, and is involved in the spread of antibiotic resistance, antigenic variation, and adaptation to the host niche.
Asher Preska Steinberg, Mingzhi Lin, Edo Kussell   +2 more
doaj   +1 more source

BRCA2 and homologous recombination [PDF]

Breast Cancer Research, 2001
Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks.
Brian J. Orelli, Douglas K. Bishop
openaire   +3 more sources

The Regulation of Homologous Recombination by Helicases [PDF]

Genes, 2020
Homologous recombination is essential for DNA repair, replication and the exchange of genetic material between parental chromosomes during meiosis. The stages of recombination involve complex reorganization of DNA structures, and the successful completion of these steps is dependent on the activities of multiple helicase enzymes.
Eric Huselid, Samuel F. Bunting
openaire   +2 more sources

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
A Chavez, A De Muyt, A Hochwagen, A Hochwagen, A Irmisch, A McAleenan, A Schwacha, A Sourirajan, A Svetlanov, AC Chan, AJ Wood, AL Marston, Alex D. Herbert, Alice Copsey, Andreas Hochwagen, Andrew Chi-ho Chan, B Rockmill, BH Lee, C Buhler, C Tapia-Alveal, DM Sheedy, E Ampatzidou, EA Andrews, EA Outwin, ER Hoffmann, Eva Hoffmann, F Osman, FZ Watts, G De Piccoli, G Vader, GA Cromie, GR Smith, GV Borner, H Murakami, Hannah G. Blitzblau, HB Lindroos, HG Blitzblau, HG Blitzblau, HG Yu, HG Yu, I Lilienthal, J Gregan, J Matos, J Matos, J Palecek, J Pan, J Torres-Rosell, J Zalevsky, JA Carballo, JA Downs, JK Holloway, JM Murray, JR Mullen, JR Mullen, JS Bickel, K Nishimura, K Zakharyevich, K Zakharyevich, KA Henderson, KP Kim, KP Kohl, KT Nishant, L Jessop, L Jessop, L Newnham, L Wu, L Xu, LE Berchowitz, LE Hang, LJ Gaskell, Louise Newnham, M Bermudez-Lopez, M Xaver, MA Roy, Michael Lichten, MJ Neale, MN Boddy, MS McMahill, N Hunter, N Hunter, N Wu, Neil Hunter, NK Kolas, O Yildiz, P Jordan, Philip W. Jordan, PR Potts, PR Potts, Prakash Arumugam, RK Clyne, S Agarwal, S Chu, S Farmer, S Gray, S Panizza, S Pebernard, S Wehrkamp-Richter, SB Buonomo, SD Oh, SD Oh, Shangming Tang, SL Andersen, Sonya Newcombe, Stephen Gray, T de los Santos, T Snowden, T Wechsler, TM Carlile, TS Kitajima, V Kaliraman, WM Fricke, X Zhao, Y Blat, YH Chen, YH Chen, Zhaobo Li   +115 more
core   +6 more sources

Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress. [PDF]

PLoS Genetics, 2016
Replications forks are routinely hindered by different endogenous stresses. Because homologous recombination plays a pivotal role in the reactivation of arrested replication forks, defects in homologous recombination reveal the initial endogenous stress ...
Therese Wilhelm, Sandrine Ragu, Indiana Magdalou, Christelle Machon, Elodie Dardillac, Hervé Técher, Jérôme Guitton, Michelle Debatisse, Bernard S Lopez   +8 more
doaj   +1 more source